A genome-wide screen for linkage in Nordic sib-pairs with multiple sclerosis
(2002) In Genes and Immunity 3(5). p.279-285- Abstract
- Genetic factors influence susceptibility to multiple sclerosis but the responsible genes remain largely undefined, association with MHC class II alleles being the only established genetic feature of the disease. The Nordic countries have a high prevalence of multiple sclerosis, and to further explore the genetic background of the disease, we have carried out a genome-wide screen for linkage in 136 sibling-pairs with multiple sclerosis from Denmark, Finland, Norway and Sweden by typing 399 microsatellite markers. Seventeen regions where the lod score exceeds the nominal 5% significance threshold (0.7) were identified-1q11-24, 2q24-32, 3p26.3, 3q21.1, 4q12, 6p25.3, 6p21-22, 6q21, 9q34.3, 10p15, 10p12-13, 11p15.5, 12q21.3, 16p13.3, 17q25.3,... (More)
- Genetic factors influence susceptibility to multiple sclerosis but the responsible genes remain largely undefined, association with MHC class II alleles being the only established genetic feature of the disease. The Nordic countries have a high prevalence of multiple sclerosis, and to further explore the genetic background of the disease, we have carried out a genome-wide screen for linkage in 136 sibling-pairs with multiple sclerosis from Denmark, Finland, Norway and Sweden by typing 399 microsatellite markers. Seventeen regions where the lod score exceeds the nominal 5% significance threshold (0.7) were identified-1q11-24, 2q24-32, 3p26.3, 3q21.1, 4q12, 6p25.3, 6p21-22, 6q21, 9q34.3, 10p15, 10p12-13, 11p15.5, 12q21.3, 16p13.3, 17q25.3, 22q12-13 and Xp22.3. Although none of these regions reaches the level of genome-wide significance, the number observed exceeds the 10 that would be expected by chance alone. Our results significantly add to the growing body of linkage data relating to multiple sclerosis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/331687
- author
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- multiple sclerosis, linkage, susceptibility gene
- in
- Genes and Immunity
- volume
- 3
- issue
- 5
- pages
- 279 - 285
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000177380000005
- pmid:12140746
- scopus:0036691491
- ISSN
- 1476-5470
- DOI
- 10.1038/sj.gene.6363866
- language
- English
- LU publication?
- yes
- id
- 364310e3-6fa7-4742-a89e-bb9939c016be (old id 331687)
- date added to LUP
- 2016-04-01 11:41:42
- date last changed
- 2022-02-25 19:56:59
@article{364310e3-6fa7-4742-a89e-bb9939c016be, abstract = {{Genetic factors influence susceptibility to multiple sclerosis but the responsible genes remain largely undefined, association with MHC class II alleles being the only established genetic feature of the disease. The Nordic countries have a high prevalence of multiple sclerosis, and to further explore the genetic background of the disease, we have carried out a genome-wide screen for linkage in 136 sibling-pairs with multiple sclerosis from Denmark, Finland, Norway and Sweden by typing 399 microsatellite markers. Seventeen regions where the lod score exceeds the nominal 5% significance threshold (0.7) were identified-1q11-24, 2q24-32, 3p26.3, 3q21.1, 4q12, 6p25.3, 6p21-22, 6q21, 9q34.3, 10p15, 10p12-13, 11p15.5, 12q21.3, 16p13.3, 17q25.3, 22q12-13 and Xp22.3. Although none of these regions reaches the level of genome-wide significance, the number observed exceeds the 10 that would be expected by chance alone. Our results significantly add to the growing body of linkage data relating to multiple sclerosis.}}, author = {{Akesson, E and Oturai, A and Berg, J and Fredrikson, S and Andersen, O and Harbo, HF and Laaksonen, M and Myhr, KM and Nyland, HI and Ryder, LP and Sandberg Wollheim, Magnhild and Sorensen, PS and Spurkland, A and Svejgaard, A and Holmans, P and Compston, A and Hillert, J and Sawcer, S}}, issn = {{1476-5470}}, keywords = {{multiple sclerosis; linkage; susceptibility gene}}, language = {{eng}}, number = {{5}}, pages = {{279--285}}, publisher = {{Nature Publishing Group}}, series = {{Genes and Immunity}}, title = {{A genome-wide screen for linkage in Nordic sib-pairs with multiple sclerosis}}, url = {{http://dx.doi.org/10.1038/sj.gene.6363866}}, doi = {{10.1038/sj.gene.6363866}}, volume = {{3}}, year = {{2002}}, }