Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Skin hydration as a tool to control the distribution and molecular effects of intermediate polarity compounds in intact stratum corneum

Pham, Quoc Dat LU ; Gregoire, Sebastien ; Biatry, Bruno ; Cassin, Guillaume ; Topgaard, Daniel LU and Sparr, Emma LU (2021) In Journal of Colloid and Interface Science 603. p.874-885
Abstract

The barrier function of the skin is mainly assured by its outermost layer, stratum corneum (SC), which consists of dead keratin-filled cells embedded in a lipid matrix. The skin is daily exposed to an environment with changing conditions in terms of hydration and different chemicals. Here we investigate how a molecule that has reasonable solubility in both hydrophobic and hydrophilic environments can be directed to certain regions in SC by changing the skin hydration. We use 1,2,3-trimethoxy propane (TMP) as a model substance and solid-state NMR on natural abundance 13C to obtain atomically resolved information on the molecular dynamics of TMP as well as SC lipid and protein components at varying hydration conditions. Upon... (More)

The barrier function of the skin is mainly assured by its outermost layer, stratum corneum (SC), which consists of dead keratin-filled cells embedded in a lipid matrix. The skin is daily exposed to an environment with changing conditions in terms of hydration and different chemicals. Here we investigate how a molecule that has reasonable solubility in both hydrophobic and hydrophilic environments can be directed to certain regions in SC by changing the skin hydration. We use 1,2,3-trimethoxy propane (TMP) as a model substance and solid-state NMR on natural abundance 13C to obtain atomically resolved information on the molecular dynamics of TMP as well as SC lipid and protein components at varying hydration conditions. Upon dehydration, TMP redistributes from the hydrophilic corneocytes to the hydrophobic SC lipid regions. In this way, TMP can act to prevent the fluid–solid lipid transition in drying conditions and be present in the corneocytes in more humid conditions. Hydration can thereby be used as a switch to control the location and action of TMP or similar compounds in complex materials like SC. The general principles described here can also have impact on other applications including lipid-based formulations in food, drug delivery and cosmetics.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Conformation, Corneocytes, Extracellular lipids, Keratin filaments, Molecular mobility, solid-state NMR, Trimethoxy propane
in
Journal of Colloid and Interface Science
volume
603
pages
12 pages
publisher
Elsevier
external identifiers
  • scopus:85109210345
  • pmid:34246090
ISSN
0021-9797
DOI
10.1016/j.jcis.2021.06.097
language
English
LU publication?
yes
additional info
Funding Information: The Swedish Research Council (VR) is gratefully acknowledged for financial support (E.S., Grant No. 2019-05296). This project has received funding from L’Oréal company.
id
3324b9cc-b5d7-41e1-9f2f-a097ac051182
date added to LUP
2021-08-12 10:20:55
date last changed
2024-07-13 16:36:08
@article{3324b9cc-b5d7-41e1-9f2f-a097ac051182,
  abstract     = {{<p>The barrier function of the skin is mainly assured by its outermost layer, stratum corneum (SC), which consists of dead keratin-filled cells embedded in a lipid matrix. The skin is daily exposed to an environment with changing conditions in terms of hydration and different chemicals. Here we investigate how a molecule that has reasonable solubility in both hydrophobic and hydrophilic environments can be directed to certain regions in SC by changing the skin hydration. We use 1,2,3-trimethoxy propane (TMP) as a model substance and solid-state NMR on natural abundance <sup>13</sup>C to obtain atomically resolved information on the molecular dynamics of TMP as well as SC lipid and protein components at varying hydration conditions. Upon dehydration, TMP redistributes from the hydrophilic corneocytes to the hydrophobic SC lipid regions. In this way, TMP can act to prevent the fluid–solid lipid transition in drying conditions and be present in the corneocytes in more humid conditions. Hydration can thereby be used as a switch to control the location and action of TMP or similar compounds in complex materials like SC. The general principles described here can also have impact on other applications including lipid-based formulations in food, drug delivery and cosmetics.</p>}},
  author       = {{Pham, Quoc Dat and Gregoire, Sebastien and Biatry, Bruno and Cassin, Guillaume and Topgaard, Daniel and Sparr, Emma}},
  issn         = {{0021-9797}},
  keywords     = {{Conformation; Corneocytes; Extracellular lipids; Keratin filaments; Molecular mobility; solid-state NMR; Trimethoxy propane}},
  language     = {{eng}},
  month        = {{12}},
  pages        = {{874--885}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Colloid and Interface Science}},
  title        = {{Skin hydration as a tool to control the distribution and molecular effects of intermediate polarity compounds in intact stratum corneum}},
  url          = {{http://dx.doi.org/10.1016/j.jcis.2021.06.097}},
  doi          = {{10.1016/j.jcis.2021.06.097}},
  volume       = {{603}},
  year         = {{2021}},
}