Feasibility study of a system for combined light dosimetry and interstitial photodynamic treatment of massive tumors
(2002) In Applied Optics 41(7). p.1462-1468- Abstract
- A system for the photodynamic laser treatment of massive tumors that employs multiple optical fibers to be inserted into the tumor mass is described. The light flux through the tumor can be assessed by use of the individual fibers both as transmitters and as receivers. With a computer model that describes the diffusive light propagation, optical dosimetry is under development, The system has been tested in an experimental animal tumor model in preparation for clinical work. Currently, delta-aminolevulinic acid is used as a sensitizer, activated by 635-nm radiation from a 2.0-W compact diode laser system. With the availability of future, highly selective drugs absorbing approximately 750 nm, larger tumor volumes should be treatable, and... (More)
- A system for the photodynamic laser treatment of massive tumors that employs multiple optical fibers to be inserted into the tumor mass is described. The light flux through the tumor can be assessed by use of the individual fibers both as transmitters and as receivers. With a computer model that describes the diffusive light propagation, optical dosimetry is under development, The system has been tested in an experimental animal tumor model in preparation for clinical work. Currently, delta-aminolevulinic acid is used as a sensitizer, activated by 635-nm radiation from a 2.0-W compact diode laser system. With the availability of future, highly selective drugs absorbing approximately 750 nm, larger tumor volumes should be treatable, and surrounding, sensitive normal tissue should be spared. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/343004
- author
- Johansson, Thomas ; Soto Thompson, Marcelo LU ; Stenberg, Maria LU ; af Klinteberg, Claes ; Andersson-Engels, Stefan LU ; Svanberg, Sune LU and Svanberg, Katarina LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Applied Optics
- volume
- 41
- issue
- 7
- pages
- 1462 - 1468
- publisher
- Optical Society of America
- external identifiers
-
- wos:000174095600035
- pmid:11900027
- scopus:0036489389
- ISSN
- 2155-3165
- language
- English
- LU publication?
- yes
- id
- 92679dc5-eac8-4bf1-8d6b-4af8609a3654 (old id 343004)
- date added to LUP
- 2016-04-01 11:38:11
- date last changed
- 2022-02-25 19:07:34
@article{92679dc5-eac8-4bf1-8d6b-4af8609a3654,
abstract = {{A system for the photodynamic laser treatment of massive tumors that employs multiple optical fibers to be inserted into the tumor mass is described. The light flux through the tumor can be assessed by use of the individual fibers both as transmitters and as receivers. With a computer model that describes the diffusive light propagation, optical dosimetry is under development, The system has been tested in an experimental animal tumor model in preparation for clinical work. Currently, delta-aminolevulinic acid is used as a sensitizer, activated by 635-nm radiation from a 2.0-W compact diode laser system. With the availability of future, highly selective drugs absorbing approximately 750 nm, larger tumor volumes should be treatable, and surrounding, sensitive normal tissue should be spared.}},
author = {{Johansson, Thomas and Soto Thompson, Marcelo and Stenberg, Maria and af Klinteberg, Claes and Andersson-Engels, Stefan and Svanberg, Sune and Svanberg, Katarina}},
issn = {{2155-3165}},
language = {{eng}},
number = {{7}},
pages = {{1462--1468}},
publisher = {{Optical Society of America}},
series = {{Applied Optics}},
title = {{Feasibility study of a system for combined light dosimetry and interstitial photodynamic treatment of massive tumors}},
url = {{https://lup.lub.lu.se/search/files/2572129/2366220.pdf}},
volume = {{41}},
year = {{2002}},
}