Effects of Bilberry (Vaccinium myrtillus) in Combination with Lactic Acid Bacteria on Intestinal Oxidative Stress Induced by Ischemia-Reperfusion in Mouse.
(2013) In Journal of Agricultural and Food Chemistry 61(14). p.3468-3478- Abstract
- Intestinal ischemia-reperfusion (I/R) results in oxidative stress, inflammation, and tissue injuries. The present study investigates the antioxidative and anti-inflammatory effects of a dietary supplement of bilberry, either alone or in combination with Lactobacillus plantarum RESO56, L. plantarum HEAL19, or Pediococcus acidilactici JAM046, in an I/R-induced model for oxidative stress in mice. A bilberry diet without addition of bacteria significantly decreased both lipid peroxidation (p = 0.001) and mucosal injury in the ileum. Of 14 anthocyanins identified in bilberry, anthocyanin arabinosides were the most resistant to absorption and microbial degradation in the intestines. Cyanidin-3-glucoside and delphinidin-3-glucoside seemed to be... (More)
- Intestinal ischemia-reperfusion (I/R) results in oxidative stress, inflammation, and tissue injuries. The present study investigates the antioxidative and anti-inflammatory effects of a dietary supplement of bilberry, either alone or in combination with Lactobacillus plantarum RESO56, L. plantarum HEAL19, or Pediococcus acidilactici JAM046, in an I/R-induced model for oxidative stress in mice. A bilberry diet without addition of bacteria significantly decreased both lipid peroxidation (p = 0.001) and mucosal injury in the ileum. Of 14 anthocyanins identified in bilberry, anthocyanin arabinosides were the most resistant to absorption and microbial degradation in the intestines. Cyanidin-3-glucoside and delphinidin-3-glucoside seemed to be mostly absorbed in the stomach and upper part of the small intestine, while malvidin-3-galactoside, peonidin-3-glucoside, peonidin-3-galactoside, and petunidin-3-galactoside seemed to be digested by the microbiota in the cecum. Bilberry strongly influenced the composition of the cecal microbiota. In conclusion, a food supplement of bilberry protected small intestine against oxidative stress and inflammation induced by ischemia-reperfusion. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3628200
- author
- Jakesevic, Maja ; Xu, Jie ; Aaby, Kjersti ; Jeppsson, Bengt LU ; Ahrné, Siv and Molin, Göran
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Agricultural and Food Chemistry
- volume
- 61
- issue
- 14
- pages
- 3468 - 3478
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- wos:000317548500015
- pmid:23488931
- scopus:84876121798
- ISSN
- 0021-8561
- DOI
- 10.1021/jf400203h
- language
- English
- LU publication?
- yes
- id
- bf1672aa-8bb0-44d1-9dd9-bc64988516ab (old id 3628200)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23488931?dopt=Abstract
- date added to LUP
- 2016-04-01 10:04:37
- date last changed
- 2022-04-27 18:14:06
@article{bf1672aa-8bb0-44d1-9dd9-bc64988516ab,
abstract = {{Intestinal ischemia-reperfusion (I/R) results in oxidative stress, inflammation, and tissue injuries. The present study investigates the antioxidative and anti-inflammatory effects of a dietary supplement of bilberry, either alone or in combination with Lactobacillus plantarum RESO56, L. plantarum HEAL19, or Pediococcus acidilactici JAM046, in an I/R-induced model for oxidative stress in mice. A bilberry diet without addition of bacteria significantly decreased both lipid peroxidation (p = 0.001) and mucosal injury in the ileum. Of 14 anthocyanins identified in bilberry, anthocyanin arabinosides were the most resistant to absorption and microbial degradation in the intestines. Cyanidin-3-glucoside and delphinidin-3-glucoside seemed to be mostly absorbed in the stomach and upper part of the small intestine, while malvidin-3-galactoside, peonidin-3-glucoside, peonidin-3-galactoside, and petunidin-3-galactoside seemed to be digested by the microbiota in the cecum. Bilberry strongly influenced the composition of the cecal microbiota. In conclusion, a food supplement of bilberry protected small intestine against oxidative stress and inflammation induced by ischemia-reperfusion.}},
author = {{Jakesevic, Maja and Xu, Jie and Aaby, Kjersti and Jeppsson, Bengt and Ahrné, Siv and Molin, Göran}},
issn = {{0021-8561}},
language = {{eng}},
number = {{14}},
pages = {{3468--3478}},
publisher = {{The American Chemical Society (ACS)}},
series = {{Journal of Agricultural and Food Chemistry}},
title = {{Effects of Bilberry (Vaccinium myrtillus) in Combination with Lactic Acid Bacteria on Intestinal Oxidative Stress Induced by Ischemia-Reperfusion in Mouse.}},
url = {{http://dx.doi.org/10.1021/jf400203h}},
doi = {{10.1021/jf400203h}},
volume = {{61}},
year = {{2013}},
}