The synthesis of bicyclo[2.2.2]octan-2,6-dione revisited
(2006) In Synthesis p.3527-3530- Abstract
- The cyclisation conditions for the formation of bicyclo[2.2.2]octan-2,6-di one (1) from 3-substituted cyclohexanones 2 and 3 have been re-investigated. Use of a medium consisting of isobutyric anhydride and trifluoroacetic acid resulted in a simplified and reproducible method for large-scale synthesis of this compound.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/378582
- author
- Widegren, Magnus ; Dietz, Melanie LU ; Friberg, Annika LU ; Frejd, Torbjörn LU ; Hahn-Hägerdal, Bärbel LU ; Gorwa-Grauslund, Marie-Francoise LU and Katz, Mikael
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- carboxylic acids, diketones, bicyclic compounds, cyclisations, anhydrides
- in
- Synthesis
- issue
- 20
- pages
- 3527 - 3530
- publisher
- Oxford Polytechnic, Oxford
- external identifiers
-
- wos:000241627700023
- scopus:33750591030
- ISSN
- 0039-7881
- DOI
- 10.1055/s-2006-942532
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240), Applied Microbiology (LTH) (011001021), Department of Chemistry (011001220)
- id
- ffaed0cc-df25-4374-958e-c2763c9726d5 (old id 378582)
- date added to LUP
- 2016-04-01 15:51:10
- date last changed
- 2022-01-28 07:33:17
@article{ffaed0cc-df25-4374-958e-c2763c9726d5, abstract = {{The cyclisation conditions for the formation of bicyclo[2.2.2]octan-2,6-di one (1) from 3-substituted cyclohexanones 2 and 3 have been re-investigated. Use of a medium consisting of isobutyric anhydride and trifluoroacetic acid resulted in a simplified and reproducible method for large-scale synthesis of this compound.}}, author = {{Widegren, Magnus and Dietz, Melanie and Friberg, Annika and Frejd, Torbjörn and Hahn-Hägerdal, Bärbel and Gorwa-Grauslund, Marie-Francoise and Katz, Mikael}}, issn = {{0039-7881}}, keywords = {{carboxylic acids; diketones; bicyclic compounds; cyclisations; anhydrides}}, language = {{eng}}, number = {{20}}, pages = {{3527--3530}}, publisher = {{Oxford Polytechnic, Oxford}}, series = {{Synthesis}}, title = {{The synthesis of bicyclo[2.2.2]octan-2,6-dione revisited}}, url = {{http://dx.doi.org/10.1055/s-2006-942532}}, doi = {{10.1055/s-2006-942532}}, year = {{2006}}, }