Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Overall cancer incidence not increased after prosthetic knee replacement : 14,551 patients followed for 66,622 person-years

Lewold, S LU ; Olsson, Håkan LU orcid ; Gustafson, P LU ; Rydholm, A LU and Lidgren, L LU (1996) In International Journal of Cancer 68(1). p.3-30
Abstract

It is unknown whether patients as a consequence of prosthetic joint replacement are at a higher risk of developing cancer. We therefore analyzed cancer incidence following prosthetic knee replacement (TKR). The observed cancer incidence in 14,551 patients from the population-based Swedish Knee Arthroplasty Register who have undergone TKR because of osteoarthrosis (OA, n = 10,120) or rheumatoid arthritis (RA, n = 4431) were compared with the expected cancer incidence for a Swedish reference population. The cohort was followed for a total of 66,622 person-years. We followed 33% of the patients with OA and 59% of those with RA for more than 5 years. All patients who underwent TKR, whether for OA or for RA, had lower than expected total... (More)

It is unknown whether patients as a consequence of prosthetic joint replacement are at a higher risk of developing cancer. We therefore analyzed cancer incidence following prosthetic knee replacement (TKR). The observed cancer incidence in 14,551 patients from the population-based Swedish Knee Arthroplasty Register who have undergone TKR because of osteoarthrosis (OA, n = 10,120) or rheumatoid arthritis (RA, n = 4431) were compared with the expected cancer incidence for a Swedish reference population. The cohort was followed for a total of 66,622 person-years. We followed 33% of the patients with OA and 59% of those with RA for more than 5 years. All patients who underwent TKR, whether for OA or for RA, had lower than expected total cancer incidence. We found a markedly low incidence of colorectal carcinoma, especially in patients with RA. Our results do not indicate an increased incidence of cancer following TKR.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Arthritis, Rheumatoid, Colorectal Neoplasms, Female, Humans, Knee Prosthesis, Male, Neoplasms, Osteoarthritis, Sweden, Time Factors
in
International Journal of Cancer
volume
68
issue
1
pages
4 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:0029853570
  • pmid:8895536
ISSN
0020-7136
DOI
10.1002/(SICI)1097-0215(19960927)68:1<30::AID-IJC6>3.0.CO;2-Y
language
English
LU publication?
yes
id
403425a1-8626-4410-a168-038a1fed6f27
date added to LUP
2016-09-18 12:50:53
date last changed
2024-01-04 12:33:41
@article{403425a1-8626-4410-a168-038a1fed6f27,
  abstract     = {{<p>It is unknown whether patients as a consequence of prosthetic joint replacement are at a higher risk of developing cancer. We therefore analyzed cancer incidence following prosthetic knee replacement (TKR). The observed cancer incidence in 14,551 patients from the population-based Swedish Knee Arthroplasty Register who have undergone TKR because of osteoarthrosis (OA, n = 10,120) or rheumatoid arthritis (RA, n = 4431) were compared with the expected cancer incidence for a Swedish reference population. The cohort was followed for a total of 66,622 person-years. We followed 33% of the patients with OA and 59% of those with RA for more than 5 years. All patients who underwent TKR, whether for OA or for RA, had lower than expected total cancer incidence. We found a markedly low incidence of colorectal carcinoma, especially in patients with RA. Our results do not indicate an increased incidence of cancer following TKR.</p>}},
  author       = {{Lewold, S and Olsson, Håkan and Gustafson, P and Rydholm, A and Lidgren, L}},
  issn         = {{0020-7136}},
  keywords     = {{Arthritis, Rheumatoid; Colorectal Neoplasms; Female; Humans; Knee Prosthesis; Male; Neoplasms; Osteoarthritis; Sweden; Time Factors}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{1}},
  pages        = {{3--30}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{International Journal of Cancer}},
  title        = {{Overall cancer incidence not increased after prosthetic knee replacement : 14,551 patients followed for 66,622 person-years}},
  url          = {{http://dx.doi.org/10.1002/(SICI)1097-0215(19960927)68:1<30::AID-IJC6>3.0.CO;2-Y}},
  doi          = {{10.1002/(SICI)1097-0215(19960927)68:1<30::AID-IJC6>3.0.CO;2-Y}},
  volume       = {{68}},
  year         = {{1996}},
}