Comparative Studies on Human and Rat Basic Helix-loop-helix Proteins
(2011) In Asian Journal of Biological Sciences p.601-608- Abstract
- The basic Helix-Loop-Helix (bHLH) proteins are a family of transcription factors that are found in almost all eukaryotic genomes. This family of proteins regulates a variety of biological processes including embryonic development. Here we describe the catalog of human, mouse and rat bHLH proteins. Extensive in silico studies identified 121 human, 121 mouse and 120 rat bHLH proteins. Human has orthologs for 119 rat bHLH proteins. Two bHLH proteins are found only in human, while human lacks one rodent specific bHLH protein, MYCS. Fifty bHLH protein families are present in all three lineages. Forty nine bHLH proteins contain 16 additional domains. Orthologous bHLH pairs vary in sequence conservation along their length, creating a map of... (More)
- The basic Helix-Loop-Helix (bHLH) proteins are a family of transcription factors that are found in almost all eukaryotic genomes. This family of proteins regulates a variety of biological processes including embryonic development. Here we describe the catalog of human, mouse and rat bHLH proteins. Extensive in silico studies identified 121 human, 121 mouse and 120 rat bHLH proteins. Human has orthologs for 119 rat bHLH proteins. Two bHLH proteins are found only in human, while human lacks one rodent specific bHLH protein, MYCS. Fifty bHLH protein families are present in all three lineages. Forty nine bHLH proteins contain 16 additional domains. Orthologous bHLH pairs vary in sequence conservation along their length, creating a map of functionally important regions for every bHLH protein pair. Many species-specific sequence inserts exist. This study provides a comprehensive overview of bHLH proteins. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4250277
- author
- Kabir, Nuzhat N. ; Hossain, Mohammad I. and Kazi, Julhash U. LU
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Asian Journal of Biological Sciences
- pages
- 601 - 608
- publisher
- Science Alert
- ISSN
- 1996-3351
- DOI
- 10.3923/ajbs.2011.601.608
- language
- English
- LU publication?
- no
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Experimental Clinical Chemistry (013016010)
- id
- 234eec0f-35c0-453b-be0a-cf4e1679822e (old id 4250277)
- alternative location
- https://www.researchgate.net/publication/230787815_Comparative_Studies_on_Human_and_Rat_Basic_Helix-loop-helix_Proteins/file/d912f504648d2b8019.pdf?origin=publication_detail
- date added to LUP
- 2016-04-04 14:18:47
- date last changed
- 2020-05-13 10:49:38
@article{234eec0f-35c0-453b-be0a-cf4e1679822e, abstract = {{The basic Helix-Loop-Helix (bHLH) proteins are a family of transcription factors that are found in almost all eukaryotic genomes. This family of proteins regulates a variety of biological processes including embryonic development. Here we describe the catalog of human, mouse and rat bHLH proteins. Extensive in silico studies identified 121 human, 121 mouse and 120 rat bHLH proteins. Human has orthologs for 119 rat bHLH proteins. Two bHLH proteins are found only in human, while human lacks one rodent specific bHLH protein, MYCS. Fifty bHLH protein families are present in all three lineages. Forty nine bHLH proteins contain 16 additional domains. Orthologous bHLH pairs vary in sequence conservation along their length, creating a map of functionally important regions for every bHLH protein pair. Many species-specific sequence inserts exist. This study provides a comprehensive overview of bHLH proteins.}}, author = {{Kabir, Nuzhat N. and Hossain, Mohammad I. and Kazi, Julhash U.}}, issn = {{1996-3351}}, language = {{eng}}, pages = {{601--608}}, publisher = {{Science Alert}}, series = {{Asian Journal of Biological Sciences}}, title = {{Comparative Studies on Human and Rat Basic Helix-loop-helix Proteins}}, url = {{https://lup.lub.lu.se/search/files/6331281/4250508.pdf}}, doi = {{10.3923/ajbs.2011.601.608}}, year = {{2011}}, }