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- 2018
- De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia
- Bruton’s tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma
- Acute leukemia cells resistant to PI3K/mTOR inhibition display upregulation of P2RY14 expression
- SRC-like adaptor protein 2 (SLAP2) is a negative regulator of KIT-D816V-mediated oncogenic transformation
- 2017
- The Src family kinase LCK cooperates with oncogenic FLT3/ITD in cellular transformation
- The dual specificity PI3K/mTOR inhibitor PKI-587 displays efficacy against T-cell acute lymphoblastic leukemia (T-ALL)
- ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling
- Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD
- T-cell acute lymphoblastic leukemia cells display activation of different survival pathways
- KITD816V induces SRC-mediated tyrosine phosphorylation of MITF and altered transcription program in melanoma