Distinct inflammatory mediator patterns characterize infectious and sterile systemic inflammation in febrile neutropenic hematology patients.
(2014) In PLoS ONE 9(3).- Abstract
- Invasive infections and sterile tissue damage can both give rise to systemic inflammation with fever and production of inflammatory mediators. This makes it difficult to diagnose infections in patients who are already inflamed, e.g. due to cell and tissue damage. For example, fever in patients with hematological malignancies may depend on infection, lysis of malignant cells, and/or chemotherapy-induced mucosal damage. We hypothesized that it would be possible to distinguish patterns of inflammatory mediators characterizing infectious and non-infectious causes of inflammation, respectively. Analysis of a broad range of parameters using a multivariate method of pattern recognition was done for this purpose.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4382981
- author
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 9
- issue
- 3
- article number
- e92319
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- pmid:24642872
- wos:000333259900120
- scopus:84898913716
- pmid:24642872
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0092319
- language
- English
- LU publication?
- yes
- id
- 6b7f547f-c6f6-447b-bf13-c7ac2ebc541e (old id 4382981)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24642872?dopt=Abstract
- date added to LUP
- 2016-04-01 14:11:25
- date last changed
- 2022-04-06 17:17:05
@article{6b7f547f-c6f6-447b-bf13-c7ac2ebc541e, abstract = {{Invasive infections and sterile tissue damage can both give rise to systemic inflammation with fever and production of inflammatory mediators. This makes it difficult to diagnose infections in patients who are already inflamed, e.g. due to cell and tissue damage. For example, fever in patients with hematological malignancies may depend on infection, lysis of malignant cells, and/or chemotherapy-induced mucosal damage. We hypothesized that it would be possible to distinguish patterns of inflammatory mediators characterizing infectious and non-infectious causes of inflammation, respectively. Analysis of a broad range of parameters using a multivariate method of pattern recognition was done for this purpose.}}, author = {{Wennerås, Christine and Hagberg, Lars and Andersson, Rune and Hynsjö, Lars and Lindahl, Anders and Okroj, Marcin and Blom, Anna and Johansson, Peter and Andreasson, Björn and Gottfries, Johan and Wold, Agnes E}}, issn = {{1932-6203}}, language = {{eng}}, number = {{3}}, publisher = {{Public Library of Science (PLoS)}}, series = {{PLoS ONE}}, title = {{Distinct inflammatory mediator patterns characterize infectious and sterile systemic inflammation in febrile neutropenic hematology patients.}}, url = {{https://lup.lub.lu.se/search/files/3835154/4646204}}, doi = {{10.1371/journal.pone.0092319}}, volume = {{9}}, year = {{2014}}, }