Leukocyte telomere length is not associated with mortality in older men.
(2014) In Experimental Gerontology 57(Apr 30). p.6-12- Abstract
- Leukocyte telomere length (LTL) is related to the aging of somatic cells. We hypothesized that LTL is inversely associated with mortality in elderly men. LTL was measured in 2744 elderly men (mean age 75.5, range 69-81years) included in the prospective population-based MrOS-Sweden study. Mortality data were obtained from national health registers with no loss of follow-up. During the follow-up (mean 6.0years), 556 (20%) of the participants died. Using Cox proportional hazards regression, tertile of LTL did not associate with all-cause mortality [tertile 1 (shortest) or 2 (middle) vs. tertile 3 (longest); hazard ratio (HR)=1.05, 95% confidence interval (CI) 0.85-1.28 and HR=0.97, 95% CI 0.79-1.19, respectively]. Furthermore, LTL did not... (More)
- Leukocyte telomere length (LTL) is related to the aging of somatic cells. We hypothesized that LTL is inversely associated with mortality in elderly men. LTL was measured in 2744 elderly men (mean age 75.5, range 69-81years) included in the prospective population-based MrOS-Sweden study. Mortality data were obtained from national health registers with no loss of follow-up. During the follow-up (mean 6.0years), 556 (20%) of the participants died. Using Cox proportional hazards regression, tertile of LTL did not associate with all-cause mortality [tertile 1 (shortest) or 2 (middle) vs. tertile 3 (longest); hazard ratio (HR)=1.05, 95% confidence interval (CI) 0.85-1.28 and HR=0.97, 95% CI 0.79-1.19, respectively]. Furthermore, LTL did not associate with cancer (197 events) or cardiovascular disease (CVD, 206 events) mortality (tertile 1 vs. tertile 3; HR=0.94, 95% CI 0.67-1.34 and HR=0.94, 95% CI 0.68-1.30, respectively). The lack of association between LTL and mortality remained also after adjustment for multiple covariates. Our results demonstrate that LTL is not associated with all-cause mortality or mortality due to cancer or CVD in elderly men. Further studies are needed to determine whether LTL can predict the risk of mortality in elderly women. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4455924
- author
- Svensson, Johan ; Karlsson, Magnus LU ; Ljunggren, Osten ; Tivesten, Asa ; Mellström, Dan and Movérare-Skrtic, Sofia
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Experimental Gerontology
- volume
- 57
- issue
- Apr 30
- pages
- 6 - 12
- publisher
- Elsevier
- external identifiers
-
- pmid:24793325
- wos:000341374300002
- scopus:84899786113
- pmid:24793325
- ISSN
- 1873-6815
- DOI
- 10.1016/j.exger.2014.04.013
- language
- English
- LU publication?
- yes
- id
- d7fe6f7a-b3d7-4874-bbcf-d632f9a98b64 (old id 4455924)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24793325?dopt=Abstract
- date added to LUP
- 2016-04-01 10:07:41
- date last changed
- 2022-04-19 22:50:47
@article{d7fe6f7a-b3d7-4874-bbcf-d632f9a98b64,
abstract = {{Leukocyte telomere length (LTL) is related to the aging of somatic cells. We hypothesized that LTL is inversely associated with mortality in elderly men. LTL was measured in 2744 elderly men (mean age 75.5, range 69-81years) included in the prospective population-based MrOS-Sweden study. Mortality data were obtained from national health registers with no loss of follow-up. During the follow-up (mean 6.0years), 556 (20%) of the participants died. Using Cox proportional hazards regression, tertile of LTL did not associate with all-cause mortality [tertile 1 (shortest) or 2 (middle) vs. tertile 3 (longest); hazard ratio (HR)=1.05, 95% confidence interval (CI) 0.85-1.28 and HR=0.97, 95% CI 0.79-1.19, respectively]. Furthermore, LTL did not associate with cancer (197 events) or cardiovascular disease (CVD, 206 events) mortality (tertile 1 vs. tertile 3; HR=0.94, 95% CI 0.67-1.34 and HR=0.94, 95% CI 0.68-1.30, respectively). The lack of association between LTL and mortality remained also after adjustment for multiple covariates. Our results demonstrate that LTL is not associated with all-cause mortality or mortality due to cancer or CVD in elderly men. Further studies are needed to determine whether LTL can predict the risk of mortality in elderly women.}},
author = {{Svensson, Johan and Karlsson, Magnus and Ljunggren, Osten and Tivesten, Asa and Mellström, Dan and Movérare-Skrtic, Sofia}},
issn = {{1873-6815}},
language = {{eng}},
number = {{Apr 30}},
pages = {{6--12}},
publisher = {{Elsevier}},
series = {{Experimental Gerontology}},
title = {{Leukocyte telomere length is not associated with mortality in older men.}},
url = {{http://dx.doi.org/10.1016/j.exger.2014.04.013}},
doi = {{10.1016/j.exger.2014.04.013}},
volume = {{57}},
year = {{2014}},
}