Causes of death in patients with extranodal cancer of unknown primary: searching for the primary site
(2014) In BMC Cancer 14.- Abstract
- Background: Cancer of unknown primary (CUP) is a fatal cancer, accounting for 3-5% of all diagnosed cancers. Finding the primary site is important for therapeutic choices and we believe that the organ which is designated as the cause of death may give clues about the primary site. Methods: A total of 20,570 patients with CUP were identified from the Swedish Family-Cancer Database. Causes of death - as reported in the death certificate - were investigated, analyzing reported metastatic sites and histological subtypes separately. Survival was compared with metastatic cancer with a known primary tumor. Results: An organ-specific cancer could be identified as a cause of death in approximately 60% of all CUP patients with adenocarcinoma or... (More)
- Background: Cancer of unknown primary (CUP) is a fatal cancer, accounting for 3-5% of all diagnosed cancers. Finding the primary site is important for therapeutic choices and we believe that the organ which is designated as the cause of death may give clues about the primary site. Methods: A total of 20,570 patients with CUP were identified from the Swedish Family-Cancer Database. Causes of death - as reported in the death certificate - were investigated, analyzing reported metastatic sites and histological subtypes separately. Survival was compared with metastatic cancer with a known primary tumor. Results: An organ-specific cancer could be identified as a cause of death in approximately 60% of all CUP patients with adenocarcinoma or undifferentiated histology. In adenocarcinoma, lung cancer was the most frequent cause of death (20%), followed by pancreatic cancer (14%), and ovarian cancer (11%). Lung cancer was the most common cause of death in patients with CUP metastases diagnosed in the nervous system (69%), respiratory system (53%), and bone (47%), whereas ovarian cancer was the most common cause of death when CUP was diagnosed in the pelvis (47%) or the peritoneum (32%). In CUP diagnosed in the liver, liver and pancreatic cancers accounted for 26% and 22% of deaths, respectively. Also in squamous cell CUP, lung cancer was the most common cause of death (45%). Conclusions: According to the causes of death, the primary site appeared frequently to be either the organ where CUP metastases were diagnosed or an organ which may be traced through the known metastatic patterns of different cancer types. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4609150
- author
- Riihimäki, Matias LU ; Hemminki, Akseli ; Sundquist, Kristina LU and Hemminki, Kari LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cancer of unknown primary, CUP, Cause of death
- in
- BMC Cancer
- volume
- 14
- article number
- 439
- publisher
- BioMed Central (BMC)
- external identifiers
-
- wos:000338163200001
- scopus:84902051187
- pmid:24929562
- ISSN
- 1471-2407
- DOI
- 10.1186/1471-2407-14-439
- language
- English
- LU publication?
- yes
- id
- 50f729a0-fd44-4ff8-ab62-6b40c641009b (old id 4609150)
- date added to LUP
- 2016-04-01 13:52:53
- date last changed
- 2022-01-27 21:38:11
@article{50f729a0-fd44-4ff8-ab62-6b40c641009b,
abstract = {{Background: Cancer of unknown primary (CUP) is a fatal cancer, accounting for 3-5% of all diagnosed cancers. Finding the primary site is important for therapeutic choices and we believe that the organ which is designated as the cause of death may give clues about the primary site. Methods: A total of 20,570 patients with CUP were identified from the Swedish Family-Cancer Database. Causes of death - as reported in the death certificate - were investigated, analyzing reported metastatic sites and histological subtypes separately. Survival was compared with metastatic cancer with a known primary tumor. Results: An organ-specific cancer could be identified as a cause of death in approximately 60% of all CUP patients with adenocarcinoma or undifferentiated histology. In adenocarcinoma, lung cancer was the most frequent cause of death (20%), followed by pancreatic cancer (14%), and ovarian cancer (11%). Lung cancer was the most common cause of death in patients with CUP metastases diagnosed in the nervous system (69%), respiratory system (53%), and bone (47%), whereas ovarian cancer was the most common cause of death when CUP was diagnosed in the pelvis (47%) or the peritoneum (32%). In CUP diagnosed in the liver, liver and pancreatic cancers accounted for 26% and 22% of deaths, respectively. Also in squamous cell CUP, lung cancer was the most common cause of death (45%). Conclusions: According to the causes of death, the primary site appeared frequently to be either the organ where CUP metastases were diagnosed or an organ which may be traced through the known metastatic patterns of different cancer types.}},
author = {{Riihimäki, Matias and Hemminki, Akseli and Sundquist, Kristina and Hemminki, Kari}},
issn = {{1471-2407}},
keywords = {{Cancer of unknown primary; CUP; Cause of death}},
language = {{eng}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Cancer}},
title = {{Causes of death in patients with extranodal cancer of unknown primary: searching for the primary site}},
url = {{https://lup.lub.lu.se/search/files/3641897/8147415}},
doi = {{10.1186/1471-2407-14-439}},
volume = {{14}},
year = {{2014}},
}