Greater loss of von Economo neurons than loss of layer II and III neurons in behavioral variant frontotemporal dementia.
Santillo, Alexander LU
and Englund, Elisabet
LU
(2014)
In American Journal of Neurodegenerative Disease
3(2).
p.64-71
- Abstract
- Previous studies have shown a selective reduction of von Economo neurons (VENs) in behavioral variant frontotemporal dementia (bvFTD). However, the alleged selectivity rests on the comparison between VENs and other neurons in cortical layer V, while it has been established that neurons in the superficial cortical layers (I-III) are particularly affected in bvFTD. The purpose of this study was to examine loss the loss of VENs in comparison with that of non-VEN-neurons of superficial cortical layers. VENs and non-VEN-neurons of cortical layer V and layers II+III were quantified in the anterior cingulate cortex in 16 cases of bvFTD, 12 non-demented controls and 10 cases of Alzheimer's disease (AD). In bvFTD VENs were more depleted than... (More)
- Previous studies have shown a selective reduction of von Economo neurons (VENs) in behavioral variant frontotemporal dementia (bvFTD). However, the alleged selectivity rests on the comparison between VENs and other neurons in cortical layer V, while it has been established that neurons in the superficial cortical layers (I-III) are particularly affected in bvFTD. The purpose of this study was to examine loss the loss of VENs in comparison with that of non-VEN-neurons of superficial cortical layers. VENs and non-VEN-neurons of cortical layer V and layers II+III were quantified in the anterior cingulate cortex in 16 cases of bvFTD, 12 non-demented controls and 10 cases of Alzheimer's disease (AD). In bvFTD VENs were more depleted than non-VEN-neurons of layers V and II+III. Also, non-VEN-neurons of layer II+III showed a greater density reduction than those of layer V in bvFTD. VEN density was also reduced in AD, albeit to a lesser extent than in bvFTD, and the differences between bvFTD and AD were only significant when relating VEN loss to that of layer V neurons. Our study strengthens the view of VENs as a particularly sensitive neuronal type of bvFTD, and appears to be on a continuum with the loss of other neurons both in bvFTD and between conditions. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4691306
- author
- Santillo, Alexander
LU
and Englund, Elisabet
LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- American Journal of Neurodegenerative Disease
- volume
- 3
- issue
- 2
- pages
- 64 - 71
- publisher
- e-Century Publishing
- external identifiers
-
- pmid:25232511
- scopus:84980053693
- ISSN
- 2165-591X
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Clinical Memory Research Unit (013242610)
- id
- 0aff9ce8-b5d4-4034-9b97-b30078924662 (old id 4691306)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25232511?dopt=Abstract
- date added to LUP
- 2016-04-01 14:50:56
- date last changed
- 2022-05-08 01:11:24
@article{0aff9ce8-b5d4-4034-9b97-b30078924662,
abstract = {{Previous studies have shown a selective reduction of von Economo neurons (VENs) in behavioral variant frontotemporal dementia (bvFTD). However, the alleged selectivity rests on the comparison between VENs and other neurons in cortical layer V, while it has been established that neurons in the superficial cortical layers (I-III) are particularly affected in bvFTD. The purpose of this study was to examine loss the loss of VENs in comparison with that of non-VEN-neurons of superficial cortical layers. VENs and non-VEN-neurons of cortical layer V and layers II+III were quantified in the anterior cingulate cortex in 16 cases of bvFTD, 12 non-demented controls and 10 cases of Alzheimer's disease (AD). In bvFTD VENs were more depleted than non-VEN-neurons of layers V and II+III. Also, non-VEN-neurons of layer II+III showed a greater density reduction than those of layer V in bvFTD. VEN density was also reduced in AD, albeit to a lesser extent than in bvFTD, and the differences between bvFTD and AD were only significant when relating VEN loss to that of layer V neurons. Our study strengthens the view of VENs as a particularly sensitive neuronal type of bvFTD, and appears to be on a continuum with the loss of other neurons both in bvFTD and between conditions.}},
author = {{Santillo, Alexander and Englund, Elisabet}},
issn = {{2165-591X}},
language = {{eng}},
number = {{2}},
pages = {{64--71}},
publisher = {{e-Century Publishing}},
series = {{American Journal of Neurodegenerative Disease}},
title = {{Greater loss of von Economo neurons than loss of layer II and III neurons in behavioral variant frontotemporal dementia.}},
url = {{https://lup.lub.lu.se/search/files/4198157/5322748}},
volume = {{3}},
year = {{2014}},
}