Cord blood insulinoma-associated protein 2 autoantibodies are associated with increased risk of type 1 diabetes in the population-based Diabetes Prediction in Skane study
Lundgren, Markus LU ; Lynch, Kristian ; Larsson, Christer LU ; Elding Larsson, Helena LU and Carlsson, Annelie LU
(2015)
In Diabetologia
58(1).
p.75-78
- Abstract
- Aims/hypothesis The aim of this study was to examine the effect of cord blood autoantibodies on the risk for type 1 diabetes in children followed prospectively from birth. Methods The Diabetes Prediction in Skane (DiPiS) study consists of 35,853 children from the general population born during 2000-2004. Samples were collected at birth and analysed for HLA genotypes and autoantibodies to glutamate decarboxylase 65 (GAD65), insulin and insulinoma-associated protein 2 (IA-2). After adjusting for HLA, sex, maternal age and parental type 1 diabetes, independent associations with risk of diabetes were assessed using multivariate Cox proportional hazards models. Results In total, 151 children (0.4%) had developed type 1 diabetes by the end of... (More)
- Aims/hypothesis The aim of this study was to examine the effect of cord blood autoantibodies on the risk for type 1 diabetes in children followed prospectively from birth. Methods The Diabetes Prediction in Skane (DiPiS) study consists of 35,853 children from the general population born during 2000-2004. Samples were collected at birth and analysed for HLA genotypes and autoantibodies to glutamate decarboxylase 65 (GAD65), insulin and insulinoma-associated protein 2 (IA-2). After adjusting for HLA, sex, maternal age and parental type 1 diabetes, independent associations with risk of diabetes were assessed using multivariate Cox proportional hazards models. Results In total, 151 children (0.4%) had developed type 1 diabetes by the end of 2013 at a median age of 5.8 years (0.8-12.2 years). In the multivariate analysis, the presence of IA-2 autoantibodies (IA-2A) in cord blood (HR 6.88, 95% CI 1.46,32.4; p = 0.003), but not maternal diabetes (HR 1.38, 95% CI 0.24,7.84; p = 0.71), was associated with risk of developing type 1 diabetes. No increased risk could be seen for the presence of autoantibodies to GAD65 or insulin. Conclusions/interpretation Our study indicates that the presence of cord blood IA-2A superimposes maternal diabetes and other cord blood islet autoantibodies as a predictor of type 1 diabetes development in the child. These findings may be of significance for future screening and study protocols on type 1 diabetes prediction. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4950724
- author
- Lundgren, Markus
LU
; Lynch, Kristian
; Larsson, Christer
LU
; Elding Larsson, Helena
LU
and Carlsson, Annelie
LU
- author collaboration
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- GAD65 autoantibodies, IA-2 autoantibodies, Insulin autoantibodies, Paediatric, Prediction, Type 1 diabetes
- in
- Diabetologia
- volume
- 58
- issue
- 1
- pages
- 75 - 78
- publisher
- Springer
- external identifiers
-
- wos:000346022300012
- scopus:84916597779
- pmid:25273346
- ISSN
- 1432-0428
- DOI
- 10.1007/s00125-014-3394-6
- language
- English
- LU publication?
- yes
- id
- e6f2ba87-ef25-4d01-87bc-7059acaff48a (old id 4950724)
- date added to LUP
- 2016-04-01 09:55:09
- date last changed
- 2022-04-04 00:37:37
@article{e6f2ba87-ef25-4d01-87bc-7059acaff48a,
abstract = {{Aims/hypothesis The aim of this study was to examine the effect of cord blood autoantibodies on the risk for type 1 diabetes in children followed prospectively from birth. Methods The Diabetes Prediction in Skane (DiPiS) study consists of 35,853 children from the general population born during 2000-2004. Samples were collected at birth and analysed for HLA genotypes and autoantibodies to glutamate decarboxylase 65 (GAD65), insulin and insulinoma-associated protein 2 (IA-2). After adjusting for HLA, sex, maternal age and parental type 1 diabetes, independent associations with risk of diabetes were assessed using multivariate Cox proportional hazards models. Results In total, 151 children (0.4%) had developed type 1 diabetes by the end of 2013 at a median age of 5.8 years (0.8-12.2 years). In the multivariate analysis, the presence of IA-2 autoantibodies (IA-2A) in cord blood (HR 6.88, 95% CI 1.46,32.4; p = 0.003), but not maternal diabetes (HR 1.38, 95% CI 0.24,7.84; p = 0.71), was associated with risk of developing type 1 diabetes. No increased risk could be seen for the presence of autoantibodies to GAD65 or insulin. Conclusions/interpretation Our study indicates that the presence of cord blood IA-2A superimposes maternal diabetes and other cord blood islet autoantibodies as a predictor of type 1 diabetes development in the child. These findings may be of significance for future screening and study protocols on type 1 diabetes prediction.}},
author = {{Lundgren, Markus and Lynch, Kristian and Larsson, Christer and Elding Larsson, Helena and Carlsson, Annelie}},
issn = {{1432-0428}},
keywords = {{GAD65 autoantibodies; IA-2 autoantibodies; Insulin autoantibodies; Paediatric; Prediction; Type 1 diabetes}},
language = {{eng}},
number = {{1}},
pages = {{75--78}},
publisher = {{Springer}},
series = {{Diabetologia}},
title = {{Cord blood insulinoma-associated protein 2 autoantibodies are associated with increased risk of type 1 diabetes in the population-based Diabetes Prediction in Skane study}},
url = {{https://lup.lub.lu.se/search/files/1389064/7752743.pdf}},
doi = {{10.1007/s00125-014-3394-6}},
volume = {{58}},
year = {{2015}},
}