Neuroblastomas and medulloblastomas exhibit more Coxsackie adenovirus receptor expression than gliomas and other brain tumors.
Persson, Annette LU ; Fan, Xiaolong LU ; Salford, Leif LU ; Widegren, Bengt LU and Englund, Elisabet LU
(2007)
In Neuropathology
27(3).
p.233-236
- Abstract
- Adenoviral vector-mediated treatment is a potential therapy for tumors of the central nervous system. To obtain a significant therapeutic effect by adenoviral vectors, a sufficient infection is required, the power of which depends predominantly on the level of Coxsackie adenovirus receptors. We stained surgical biopsies of central nervous system tumors and neuroblastomas for Coxsackie adenovirus receptors. For gliomas, the level of the receptor was low and markedly variable among individual tumors. By contrast, neuroblastomas and medulloblastomas exhibited a higher degree of Coxsackie adenovirus receptor expression than gliomas and other brain tumors. We conclude that neuroblastomas and medulloblastomas could be suitable for... (More)
- Adenoviral vector-mediated treatment is a potential therapy for tumors of the central nervous system. To obtain a significant therapeutic effect by adenoviral vectors, a sufficient infection is required, the power of which depends predominantly on the level of Coxsackie adenovirus receptors. We stained surgical biopsies of central nervous system tumors and neuroblastomas for Coxsackie adenovirus receptors. For gliomas, the level of the receptor was low and markedly variable among individual tumors. By contrast, neuroblastomas and medulloblastomas exhibited a higher degree of Coxsackie adenovirus receptor expression than gliomas and other brain tumors. We conclude that neuroblastomas and medulloblastomas could be suitable for adenovirus-mediated gene therapy. Adverse effects of the treatment, however, must be considered because neurons and reactive astrocytes also express a significant amount of the receptor. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/540569
- author
- Persson, Annette
LU
; Fan, Xiaolong
LU
; Salford, Leif
LU
; Widegren, Bengt
LU
and Englund, Elisabet
LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Neuropathology
- volume
- 27
- issue
- 3
- pages
- 233 - 236
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000246686200004
- scopus:34249107918
- ISSN
- 0919-6544
- DOI
- 10.1111/j.1440-1789.2007.00767.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division IV (013230800), Division V (013230900), Department of Cell and Organism Biology (Closed 2011.) (011002100), Pathology, (Lund) (013030000), Neurosurgery (013026000)
- id
- f123a45f-f028-41d7-b397-0039dcb516c8 (old id 540569)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17645237&dopt=Abstract
- date added to LUP
- 2016-04-01 11:46:26
- date last changed
- 2022-01-26 18:02:18
@article{f123a45f-f028-41d7-b397-0039dcb516c8,
abstract = {{Adenoviral vector-mediated treatment is a potential therapy for tumors of the central nervous system. To obtain a significant therapeutic effect by adenoviral vectors, a sufficient infection is required, the power of which depends predominantly on the level of Coxsackie adenovirus receptors. We stained surgical biopsies of central nervous system tumors and neuroblastomas for Coxsackie adenovirus receptors. For gliomas, the level of the receptor was low and markedly variable among individual tumors. By contrast, neuroblastomas and medulloblastomas exhibited a higher degree of Coxsackie adenovirus receptor expression than gliomas and other brain tumors. We conclude that neuroblastomas and medulloblastomas could be suitable for adenovirus-mediated gene therapy. Adverse effects of the treatment, however, must be considered because neurons and reactive astrocytes also express a significant amount of the receptor.}},
author = {{Persson, Annette and Fan, Xiaolong and Salford, Leif and Widegren, Bengt and Englund, Elisabet}},
issn = {{0919-6544}},
language = {{eng}},
number = {{3}},
pages = {{233--236}},
publisher = {{Wiley-Blackwell}},
series = {{Neuropathology}},
title = {{Neuroblastomas and medulloblastomas exhibit more Coxsackie adenovirus receptor expression than gliomas and other brain tumors.}},
url = {{https://lup.lub.lu.se/search/files/2635505/626061.pdf}},
doi = {{10.1111/j.1440-1789.2007.00767.x}},
volume = {{27}},
year = {{2007}},
}