Cerebrospinal fluid levels of IL-6 are decreased and correlate with cognitive status in DLB patients.
Wennström, Malin LU ; Hall, Sara LU ; Nägga, Katarina LU ; Londos, Elisabet LU ; Minthon, Lennart LU and Hansson, Oskar LU
(2015)
In Alzheimer's Research & Therapy
7(1).
- Abstract
- Inflammatory processes have previously been shown to influence cognition and progression of dementia. An involvement of interleukin (IL)-6 has in particular been suggested as altered levels of IL-6 in cerebrospinal fluid (CSF) have been found in patients with Alzheimer's disease (AD). Also, an association between cognitive decline and levels of IL-6 in CSF have been reported. The aim of the present study was to investigate whether patients clinically diagnosed with dementia with Lewy bodies (DLB) display altered CSF IL-6 levels in comparison with patients with AD and control subjects without dementia and whether the IL-6 levels are correlated with cognitive status and biomarkers for AD and synucleinopathy.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8158947
- author
- Wennström, Malin
LU
; Hall, Sara
LU
; Nägga, Katarina
LU
; Londos, Elisabet
LU
; Minthon, Lennart
LU
and Hansson, Oskar
LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Alzheimer's Research & Therapy
- volume
- 7
- issue
- 1
- article number
- 63
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:26434635
- wos:000362245500001
- scopus:84942940978
- pmid:26434635
- ISSN
- 1758-9193
- DOI
- 10.1186/s13195-015-0145-y
- language
- English
- LU publication?
- yes
- id
- 528c0432-c4c2-4a70-b473-aad8bf9a8375 (old id 8158947)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26434635?dopt=Abstract
- date added to LUP
- 2016-04-01 13:27:36
- date last changed
- 2022-04-21 21:47:14
@article{528c0432-c4c2-4a70-b473-aad8bf9a8375,
abstract = {{Inflammatory processes have previously been shown to influence cognition and progression of dementia. An involvement of interleukin (IL)-6 has in particular been suggested as altered levels of IL-6 in cerebrospinal fluid (CSF) have been found in patients with Alzheimer's disease (AD). Also, an association between cognitive decline and levels of IL-6 in CSF have been reported. The aim of the present study was to investigate whether patients clinically diagnosed with dementia with Lewy bodies (DLB) display altered CSF IL-6 levels in comparison with patients with AD and control subjects without dementia and whether the IL-6 levels are correlated with cognitive status and biomarkers for AD and synucleinopathy.}},
author = {{Wennström, Malin and Hall, Sara and Nägga, Katarina and Londos, Elisabet and Minthon, Lennart and Hansson, Oskar}},
issn = {{1758-9193}},
language = {{eng}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{Alzheimer's Research & Therapy}},
title = {{Cerebrospinal fluid levels of IL-6 are decreased and correlate with cognitive status in DLB patients.}},
url = {{https://lup.lub.lu.se/search/files/3386599/8840920}},
doi = {{10.1186/s13195-015-0145-y}},
volume = {{7}},
year = {{2015}},
}