Non-negative least squares fitting of multi-exponential T2 decay data: Are we able to accurately measure the fraction of myelin water?
Wiggermann, Vanessa ; Vavasour, Irene M ; Hernandez-Torres, Ernedino ; Helms, Gunther LU
; MacKay, Alex L
and Rauscher, Alexander
(2019)
ISMRM 27th Annual Meeting and Exhibition
In Proc Intl Soc Magn Reson Med
27.
- Abstract
- The ability to determine the myelin water fraction (MWF) in vivo is essential to assessments of neurodevelopmental myelination and myelin damage in neurodegenerative diseases. The analysis of multi-exponential T2 decay data relies on the non-negative-least-squares (NNLS) fitting, which may be sensitive to the chosen fitting parameters. We performed simulations to explore the outcomes of NNLS under different parameter selection. The lowest allowed T2 was found to have the largest effect on correctly estimating the T2 of different water pools as well as the MWF. Lower refocusing FAs led to further underestimation of the MWF.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/852969f9-7ef3-4ab2-b134-543a4e9f30d3
- author
- Wiggermann, Vanessa
; Vavasour, Irene M
; Hernandez-Torres, Ernedino
; Helms, Gunther
LU
; MacKay, Alex L
and Rauscher, Alexander
- organization
- publishing date
- 2019-04-26
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- host publication
- Non-negative least squares fitting of multi-exponential T2 decay data: Are we able to accurately measure the fraction of myelin water?
- series title
- Proc Intl Soc Magn Reson Med
- volume
- 27
- article number
- 4402
- publisher
- International Society for Magnetic Resonance in Medicine
- conference name
- ISMRM 27th Annual Meeting and Exhibition
- conference location
- Montreal, Canada
- conference dates
- 2019-05-11 - 2019-05-16
- ISSN
- 1545-4428
- project
- T2 mapping and myelin water imaging at 7T using 3D GraSe
- language
- English
- LU publication?
- yes
- id
- 852969f9-7ef3-4ab2-b134-543a4e9f30d3
- alternative location
- http://indexsmart.mirasmart.com/ISMRM2019/PDFfiles/4402.html
- date added to LUP
- 2019-05-30 10:46:07
- date last changed
- 2022-03-16 13:57:52
@inproceedings{852969f9-7ef3-4ab2-b134-543a4e9f30d3,
abstract = {{The ability to determine the myelin water fraction (MWF) in vivo is essential to assessments of neurodevelopmental myelination and myelin damage in neurodegenerative diseases. The analysis of multi-exponential T2 decay data relies on the non-negative-least-squares (NNLS) fitting, which may be sensitive to the chosen fitting parameters. We performed simulations to explore the outcomes of NNLS under different parameter selection. The lowest allowed T2 was found to have the largest effect on correctly estimating the T2 of different water pools as well as the MWF. Lower refocusing FAs led to further underestimation of the MWF.}},
author = {{Wiggermann, Vanessa and Vavasour, Irene M and Hernandez-Torres, Ernedino and Helms, Gunther and MacKay, Alex L and Rauscher, Alexander}},
booktitle = {{Non-negative least squares fitting of multi-exponential T2 decay data: Are we able to accurately measure the fraction of myelin water?}},
issn = {{1545-4428}},
language = {{eng}},
month = {{04}},
publisher = {{International Society for Magnetic Resonance in Medicine}},
series = {{Proc Intl Soc Magn Reson Med}},
title = {{Non-negative least squares fitting of multi-exponential T2 decay data: Are we able to accurately measure the fraction of myelin water?}},
url = {{https://lup.lub.lu.se/search/files/65200312/Proc.Intl.Soc.Magn.Res.Med.27_2019_4402.pdf}},
volume = {{27}},
year = {{2019}},
}