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Limited protective effect of the CCR5 Delta 32/CCR5 Delta 32 genotype on human immunodeficiency virus infection incidence in a cohort of patients with hemophilia and selection for genotypic X4 virus

Iversen, AKN ; Christiansen, CB ; Attermann, J ; Eugen-Olsen, J ; Schulman, S ; Berntorp, Erik LU ; Ingerslev, J ; Fugger, L ; Scheibel, E and Tengborn, Lilian LU , et al. (2003) In Journal of Infectious Diseases 187(2). p.215-225
Abstract
The relationship among CCR5 genotype, cytomegalovirus infection, and disease progression and death was studied among 159 human immunodeficiency virus (HIV)-infected patients with hemophilia. One patient (0.6%) had the CCR5Delta32/CCR5Delta32 genotype (which occurs in similar to2% of the Scandinavian population) and a rapid disease course. His HIV V3 region contained genotypic features attributable to X4 virus and resembled functionally verified X4 virus and virus from patients treated with a CD4 cell-stimulating drug, tucaresol. Age-related differences in disease progression rate and survival time were seen for CCR5/CCR5 patients. Surprisingly, no protective effect of the CCR5/CCR5Delta32 genotype on disease progression or survival was... (More)
The relationship among CCR5 genotype, cytomegalovirus infection, and disease progression and death was studied among 159 human immunodeficiency virus (HIV)-infected patients with hemophilia. One patient (0.6%) had the CCR5Delta32/CCR5Delta32 genotype (which occurs in similar to2% of the Scandinavian population) and a rapid disease course. His HIV V3 region contained genotypic features attributable to X4 virus and resembled functionally verified X4 virus and virus from patients treated with a CD4 cell-stimulating drug, tucaresol. Age-related differences in disease progression rate and survival time were seen for CCR5/CCR5 patients. Surprisingly, no protective effect of the CCR5/CCR5Delta32 genotype on disease progression or survival was seen for children but was evident for adults. Age group-related immunologic differences might explain this variation, and transmission route and/or viral phenotype variation within donor virus may be related to the limited protection of the CCR5Delta32/ CCR5Delta32 genotype. Sequence comparisons indicate that X4 virus can be selected in vivo due to either absence of CCR5 receptors or relative increase of CXCR4 receptors. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Infectious Diseases
volume
187
issue
2
pages
215 - 225
publisher
Oxford University Press
external identifiers
  • pmid:12552446
  • wos:000180226500006
ISSN
1537-6613
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Clinical Coagulation Research Unit (013242510)
id
9d2f9bbe-6e90-4c6d-9e8a-51349acf6004 (old id 892092)
alternative location
http://ucp.uchicago.edu/JID/journal/issues/v187n2/020881/brief/020881.abstract.html
date added to LUP
2016-04-01 16:32:21
date last changed
2018-11-21 20:42:12
@article{9d2f9bbe-6e90-4c6d-9e8a-51349acf6004,
  abstract     = {{The relationship among CCR5 genotype, cytomegalovirus infection, and disease progression and death was studied among 159 human immunodeficiency virus (HIV)-infected patients with hemophilia. One patient (0.6%) had the CCR5Delta32/CCR5Delta32 genotype (which occurs in similar to2% of the Scandinavian population) and a rapid disease course. His HIV V3 region contained genotypic features attributable to X4 virus and resembled functionally verified X4 virus and virus from patients treated with a CD4 cell-stimulating drug, tucaresol. Age-related differences in disease progression rate and survival time were seen for CCR5/CCR5 patients. Surprisingly, no protective effect of the CCR5/CCR5Delta32 genotype on disease progression or survival was seen for children but was evident for adults. Age group-related immunologic differences might explain this variation, and transmission route and/or viral phenotype variation within donor virus may be related to the limited protection of the CCR5Delta32/ CCR5Delta32 genotype. Sequence comparisons indicate that X4 virus can be selected in vivo due to either absence of CCR5 receptors or relative increase of CXCR4 receptors.}},
  author       = {{Iversen, AKN and Christiansen, CB and Attermann, J and Eugen-Olsen, J and Schulman, S and Berntorp, Erik and Ingerslev, J and Fugger, L and Scheibel, E and Tengborn, Lilian and Gerstoft, J and Dickmeiss, E and Svejgaard, A and Skinhoj, P}},
  issn         = {{1537-6613}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{215--225}},
  publisher    = {{Oxford University Press}},
  series       = {{Journal of Infectious Diseases}},
  title        = {{Limited protective effect of the CCR5 Delta 32/CCR5 Delta 32 genotype on human immunodeficiency virus infection incidence in a cohort of patients with hemophilia and selection for genotypic X4 virus}},
  url          = {{http://ucp.uchicago.edu/JID/journal/issues/v187n2/020881/brief/020881.abstract.html}},
  volume       = {{187}},
  year         = {{2003}},
}