Phosphoproteomics to tackle brain disorders : Insight into the murine brain phosphoproteome
(2018)- Abstract
- Brain disorders affect the normal functionality of the brain causing inability in controlling certain behaviours. In the last two decades, despite the technological advancement, many biological questions concerning brain mechanisms and neural networks remain still unclear. Thus, the integration of multiple technologies could help on clarify several aspects of neurobiology.
The aim of this thesis was to study the function of certain proteins and protein-protein interactions in murine brains by using mass spectrometry-based proteomics. Since one of the main switching mechanisms in cells is the
phosphorylation of proteins, the phosphoproteome of murine brains was specifically studied.
The results presented in this thesis let to... (More) - Brain disorders affect the normal functionality of the brain causing inability in controlling certain behaviours. In the last two decades, despite the technological advancement, many biological questions concerning brain mechanisms and neural networks remain still unclear. Thus, the integration of multiple technologies could help on clarify several aspects of neurobiology.
The aim of this thesis was to study the function of certain proteins and protein-protein interactions in murine brains by using mass spectrometry-based proteomics. Since one of the main switching mechanisms in cells is the
phosphorylation of proteins, the phosphoproteome of murine brains was specifically studied.
The results presented in this thesis let to the identification of phosphoproteins implicated in molecular pathways that could be responsible for brain impairment during certain conditions like obesity (Paper I and III), anxiety and depression (Paper III) and Parkinson´s disease (Paper IV). The findings of this thesis remarkably contribute to the proteomic and neurobiology fields and set phosphoproteomics as a powerful tool for the study of neuroscience. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/95ba1af4-333b-4d56-bcd3-8cf89a68bf11
- author
- Siino, Valentina LU
- supervisor
- opponent
-
- Associate professor Greggio, Elisa, University of Padua, Italy
- organization
- publishing date
- 2018
- type
- Thesis
- publication status
- published
- subject
- keywords
- Phosphoproteomics, mass spectrometry, brain disorders, neurobiology, phosphorylation
- publisher
- Department of Immunotechnology, Lund University
- defense location
- lecture hall Lundmarksalen, Sölvegatan 27, Lund University, Faculty of Engineering LTH, Lund
- defense date
- 2018-04-27 09:00:00
- ISBN
- 978-91-7753-611-6
- 978-91-7753-610-9
- language
- English
- LU publication?
- yes
- id
- 95ba1af4-333b-4d56-bcd3-8cf89a68bf11
- date added to LUP
- 2018-04-02 17:34:38
- date last changed
- 2024-02-13 11:39:51
@phdthesis{95ba1af4-333b-4d56-bcd3-8cf89a68bf11, abstract = {{Brain disorders affect the normal functionality of the brain causing inability in controlling certain behaviours. In the last two decades, despite the technological advancement, many biological questions concerning brain mechanisms and neural networks remain still unclear. Thus, the integration of multiple technologies could help on clarify several aspects of neurobiology.<br/>The aim of this thesis was to study the function of certain proteins and protein-protein interactions in murine brains by using mass spectrometry-based proteomics. Since one of the main switching mechanisms in cells is the<br/>phosphorylation of proteins, the phosphoproteome of murine brains was specifically studied.<br/>The results presented in this thesis let to the identification of phosphoproteins implicated in molecular pathways that could be responsible for brain impairment during certain conditions like obesity (Paper I and III), anxiety and depression (Paper III) and Parkinson´s disease (Paper IV). The findings of this thesis remarkably contribute to the proteomic and neurobiology fields and set phosphoproteomics as a powerful tool for the study of neuroscience.}}, author = {{Siino, Valentina}}, isbn = {{978-91-7753-611-6}}, keywords = {{Phosphoproteomics; mass spectrometry; brain disorders; neurobiology; phosphorylation}}, language = {{eng}}, publisher = {{Department of Immunotechnology, Lund University}}, school = {{Lund University}}, title = {{Phosphoproteomics to tackle brain disorders : Insight into the murine brain phosphoproteome}}, year = {{2018}}, }