Shrunken Pore Syndrome Is Associated With Increased Levels of Atherosclerosis-Promoting Proteins
(2019) In Kidney International Reports 4(1). p.67-79- Abstract
Introduction: Shrunken pore syndrome (SPS), originally defined by cystatin C-based estimated glomerular filtration rate (eGFRcystatin C) being less than 60% of creatinine-based estimated glomerular filtration rate (eGFRcreatinine) in the absence of extrarenal influences on the plasma levels of cystatin C or creatinine, is associated with a high increase in mortality, even in the absence of reduced glomerular filtration rate (GFR). The objective of the present study was to determine whether the proteome of patients with SPS shows differences from that of patients with normal or reduced measured GFR (mGFR) without SPS.
Methods: Four patient cohorts were included: 1 cohort with normal mGFR without SPS, 1 with normal mGFR with SPS, 1... (More)
Introduction: Shrunken pore syndrome (SPS), originally defined by cystatin C-based estimated glomerular filtration rate (eGFRcystatin C) being less than 60% of creatinine-based estimated glomerular filtration rate (eGFRcreatinine) in the absence of extrarenal influences on the plasma levels of cystatin C or creatinine, is associated with a high increase in mortality, even in the absence of reduced glomerular filtration rate (GFR). The objective of the present study was to determine whether the proteome of patients with SPS shows differences from that of patients with normal or reduced measured GFR (mGFR) without SPS.
Methods: Four patient cohorts were included: 1 cohort with normal mGFR without SPS, 1 with normal mGFR with SPS, 1 with reduced mGFR without SPS, and 1 with reduced mGFR with SPS. The plasma levels of 177 selected proteins were analyzed.
Results: Differences in the levels of 30 proteins were specific for SPS; 31 differences were specific for patients with both SPS and reduced mGFR; and 27 were specific for reduced mGFR. Eighteen of the differences specific for SPS concerned proteins described as promoting, or being associated with, atherosclerosis. Twelve of the differences specific for patients with both SPS and reduced mGFR and 10 of the differences specific for reduced mGFR also concerned proteins described as promoting, or being associated with, atherosclerosis. Almost all (82 of 88) of the concentration differences represented increased levels. For SPS, but not for reduced mGFR, a correlation between protein size and increase in level was observed, with smaller proteins being associated with higher levels.
Conclusion: The high mortality in shrunken pore syndrome might be caused by the accumulation of atherosclerosis-promoting proteins in this condition.
(Less)
- author
- organization
-
- Environmental Epidemiology (research group)
- Division of Occupational and Environmental Medicine, Lund University
- EpiHealth: Epidemiology for Health
- Radiology Diagnostics, Malmö (research group)
- Cystatin C, renal disease, amyloidosis and antibiotics (research group)
- Division of Clinical Chemistry and Pharmacology
- Protease Inhibitor Research (research group)
- Department of Laboratory Medicine
- Internal Medicine - Epidemiology (research group)
- publishing date
- 2019-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cystatin C, Shrunken Pore Syndrome, creatinine, mortality, GFR
- in
- Kidney International Reports
- volume
- 4
- issue
- 1
- pages
- 67 - 79
- publisher
- Elsevier
- external identifiers
-
- scopus:85055732913
- pmid:30596170
- pmid:30596170
- ISSN
- 2468-0249
- DOI
- 10.1016/j.ekir.2018.09.002
- project
- Shrunken Pore Syndrome (SPS) - morbidity and mortality in a population with measured glomerular filtration rate (GFR)
- language
- English
- LU publication?
- yes
- id
- bb9e584f-9218-4109-82f7-31bbc6367b5d
- date added to LUP
- 2018-11-15 19:13:27
- date last changed
- 2024-09-18 06:19:55
@article{bb9e584f-9218-4109-82f7-31bbc6367b5d, abstract = {{<p>Introduction: Shrunken pore syndrome (SPS), originally defined by cystatin C-based estimated glomerular filtration rate (eGFRcystatin C) being less than 60% of creatinine-based estimated glomerular filtration rate (eGFRcreatinine) in the absence of extrarenal influences on the plasma levels of cystatin C or creatinine, is associated with a high increase in mortality, even in the absence of reduced glomerular filtration rate (GFR). The objective of the present study was to determine whether the proteome of patients with SPS shows differences from that of patients with normal or reduced measured GFR (mGFR) without SPS.</p><p>Methods: Four patient cohorts were included: 1 cohort with normal mGFR without SPS, 1 with normal mGFR with SPS, 1 with reduced mGFR without SPS, and 1 with reduced mGFR with SPS. The plasma levels of 177 selected proteins were analyzed.</p><p>Results: Differences in the levels of 30 proteins were specific for SPS; 31 differences were specific for patients with both SPS and reduced mGFR; and 27 were specific for reduced mGFR. Eighteen of the differences specific for SPS concerned proteins described as promoting, or being associated with, atherosclerosis. Twelve of the differences specific for patients with both SPS and reduced mGFR and 10 of the differences specific for reduced mGFR also concerned proteins described as promoting, or being associated with, atherosclerosis. Almost all (82 of 88) of the concentration differences represented increased levels. For SPS, but not for reduced mGFR, a correlation between protein size and increase in level was observed, with smaller proteins being associated with higher levels.</p><p>Conclusion: The high mortality in shrunken pore syndrome might be caused by the accumulation of atherosclerosis-promoting proteins in this condition.</p>}}, author = {{Sällman Almén, Markus and Björk, Jonas and Nyman, Ulf and Lindström, Veronica and Jonsson, Magnus and Abrahamson, Magnus and Schiller Vestergren, AnnaLotta and Lindhe, Örjan and Franklin, Gary and Christensson, Anders and Grubb, Anders}}, issn = {{2468-0249}}, keywords = {{cystatin C; Shrunken Pore Syndrome; creatinine; mortality; GFR}}, language = {{eng}}, number = {{1}}, pages = {{67--79}}, publisher = {{Elsevier}}, series = {{Kidney International Reports}}, title = {{Shrunken Pore Syndrome Is Associated With Increased Levels of Atherosclerosis-Promoting Proteins}}, url = {{http://dx.doi.org/10.1016/j.ekir.2018.09.002}}, doi = {{10.1016/j.ekir.2018.09.002}}, volume = {{4}}, year = {{2019}}, }