Relationships between abdominal aortic calcification, glomerular filtration rate, and cardiovascular risk factors in patients with non-dialysis dependent chronic kidney disease
(2018) In Clinical Nephrology 90(6). p.380-389- Abstract
Background: Abdominal aortic calcification (AAC) is an established risk factor for cardiovascular events in patients with chronic kidney disease (CKD). We hypothesized that AAC is associated with a decline in glomerular filtration rate (GFR) as well as with some other cardiovascular risk factors. Materials and methods: This is a cross-sectional analysis of baseline data from a randomized controlled clinical trial (RENEXC). A total of 151 patients (aged 66 ± 14 years) with an average measured GFR (mGFR) of 22.5 ± 8.2 mL/min/1.73m2, not on renal replacement therapy, irrespective of number of comorbidities, were included. GFR was measured with iohexol clearance and estimated using cystatin C- and creatinine-based equations... (More)
Background: Abdominal aortic calcification (AAC) is an established risk factor for cardiovascular events in patients with chronic kidney disease (CKD). We hypothesized that AAC is associated with a decline in glomerular filtration rate (GFR) as well as with some other cardiovascular risk factors. Materials and methods: This is a cross-sectional analysis of baseline data from a randomized controlled clinical trial (RENEXC). A total of 151 patients (aged 66 ± 14 years) with an average measured GFR (mGFR) of 22.5 ± 8.2 mL/min/1.73m2, not on renal replacement therapy, irrespective of number of comorbidities, were included. GFR was measured with iohexol clearance and estimated using cystatin C- and creatinine-based equations (eGFR). AAC was evaluated with lateral lumbar X-ray using the scoring system described by Kauppila. All patients underwent laboratory analyses, 24-hour ambulatory blood pressure monitoring, and standard echocardiography. Multiple linear regression analyses controlling for sex, age, cardiovascular comorbidities, and hypertension were performed. Results: The prevalence of AAC in this group of patients was 73%, and 47% had severe calcification (AAC score ≥ 7). More men (76%) had AAC than women (69%). AAC score was associated with mGFR (p = 0.03), eGFR (p = 0.006), plasma albumin (p = 0.006), plasma phosphate (p = 0.01), pulse pressure (p = 0.004), left ventricular mass (LVM) (p = 0.02), left atrial volume (LAV; p < 0.001), and left atrial volume index (LAVI; p = 0.001). Conclusion: AAC was highly prevalent in CKD. The degree of calcification in the abdominal aorta was strongly associated with a decline in GFR, a decrease in plasma albumin, an increase in plasma phosphate, an increase in pulse pressure, and cardiac structural changes, such as an increase in LVM, LAV, and LAVI.
(Less)
- author
- Zhou, Yunan LU ; Hellberg, Matthias LU ; Kouidi, Evangelia ; Deligiannis, Asterios ; Höglund, Peter LU and Clyne, Naomi LU
- organization
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Abdominal aortic calcification (AAC), Cardiovascular disease, Chronic kidney disease (CKD), Echocardiographic index, Glomerular filtration rate (GFR), Pulse pressure
- in
- Clinical Nephrology
- volume
- 90
- issue
- 6
- pages
- 10 pages
- publisher
- Dustri-Verlag
- external identifiers
-
- pmid:30309449
- scopus:85056661650
- ISSN
- 0301-0430
- DOI
- 10.5414/CN109441
- language
- English
- LU publication?
- yes
- id
- bbef4bad-c4fa-42b8-887d-15ec371d22a8
- date added to LUP
- 2018-11-26 13:45:51
- date last changed
- 2024-07-10 03:21:35
@article{bbef4bad-c4fa-42b8-887d-15ec371d22a8, abstract = {{<p>Background: Abdominal aortic calcification (AAC) is an established risk factor for cardiovascular events in patients with chronic kidney disease (CKD). We hypothesized that AAC is associated with a decline in glomerular filtration rate (GFR) as well as with some other cardiovascular risk factors. Materials and methods: This is a cross-sectional analysis of baseline data from a randomized controlled clinical trial (RENEXC). A total of 151 patients (aged 66 ± 14 years) with an average measured GFR (mGFR) of 22.5 ± 8.2 mL/min/1.73m<sup>2</sup>, not on renal replacement therapy, irrespective of number of comorbidities, were included. GFR was measured with iohexol clearance and estimated using cystatin C- and creatinine-based equations (eGFR). AAC was evaluated with lateral lumbar X-ray using the scoring system described by Kauppila. All patients underwent laboratory analyses, 24-hour ambulatory blood pressure monitoring, and standard echocardiography. Multiple linear regression analyses controlling for sex, age, cardiovascular comorbidities, and hypertension were performed. Results: The prevalence of AAC in this group of patients was 73%, and 47% had severe calcification (AAC score ≥ 7). More men (76%) had AAC than women (69%). AAC score was associated with mGFR (p = 0.03), eGFR (p = 0.006), plasma albumin (p = 0.006), plasma phosphate (p = 0.01), pulse pressure (p = 0.004), left ventricular mass (LVM) (p = 0.02), left atrial volume (LAV; p < 0.001), and left atrial volume index (LAVI; p = 0.001). Conclusion: AAC was highly prevalent in CKD. The degree of calcification in the abdominal aorta was strongly associated with a decline in GFR, a decrease in plasma albumin, an increase in plasma phosphate, an increase in pulse pressure, and cardiac structural changes, such as an increase in LVM, LAV, and LAVI.</p>}}, author = {{Zhou, Yunan and Hellberg, Matthias and Kouidi, Evangelia and Deligiannis, Asterios and Höglund, Peter and Clyne, Naomi}}, issn = {{0301-0430}}, keywords = {{Abdominal aortic calcification (AAC); Cardiovascular disease; Chronic kidney disease (CKD); Echocardiographic index; Glomerular filtration rate (GFR); Pulse pressure}}, language = {{eng}}, number = {{6}}, pages = {{380--389}}, publisher = {{Dustri-Verlag}}, series = {{Clinical Nephrology}}, title = {{Relationships between abdominal aortic calcification, glomerular filtration rate, and cardiovascular risk factors in patients with non-dialysis dependent chronic kidney disease}}, url = {{http://dx.doi.org/10.5414/CN109441}}, doi = {{10.5414/CN109441}}, volume = {{90}}, year = {{2018}}, }