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Vibrotactile sense in median and ulnar nerve innervated fingers of men with Type 2 diabetes, normal or impaired glucose tolerance.

Dahlin, Lars LU ; Thrainsdottir, Soley LU ; Cederlund, Ragnhild LU ; Thomsen, Niels LU ; Eriksson, Karl-Fredrik LU ; Rosén, Ingmar LU ; Speidel, T and Sundqvist, G (2008) In Diabetic medicine : a journal of the British Diabetic Association 25. p.543-549
Abstract
Aims To investigate vibrotactile sense (large fibre neuropathy) at different frequencies in index and little fingers (median and ulnar nerves, respectively) of subjects with diabetes, or impaired (IGT) or normal glucose tolerance (NGT). Methods Vibration thresholds (tactilometry at seven frequencies (8, 16, 32, 64, 125, 250 and 500 Hz)) and median nerve function (electrophysiology) were examined in men (age 73.4 +/- 0.12 years; n = 58, mean +/- sd) with persistent NGT (n = 28) or IGT (n = 7) or with Type 2 diabetes mellitus (T2DM) (n = 23) for > 15 years. Results HbA(1c) was increased and vibrotactile sense (sensibility index) was impaired in index and little fingers in men with T2DM. Vibration thresholds were particularly increased at... (More)
Aims To investigate vibrotactile sense (large fibre neuropathy) at different frequencies in index and little fingers (median and ulnar nerves, respectively) of subjects with diabetes, or impaired (IGT) or normal glucose tolerance (NGT). Methods Vibration thresholds (tactilometry at seven frequencies (8, 16, 32, 64, 125, 250 and 500 Hz)) and median nerve function (electrophysiology) were examined in men (age 73.4 +/- 0.12 years; n = 58, mean +/- sd) with persistent NGT (n = 28) or IGT (n = 7) or with Type 2 diabetes mellitus (T2DM) (n = 23) for > 15 years. Results HbA(1c) was increased and vibrotactile sense (sensibility index) was impaired in index and little fingers in men with T2DM. Vibration thresholds were particularly increased at 16, 250 and 500 Hz in the little finger (ulnar nerve). T2DM subjects showed electrophysiological (gold standard) signs of neuropathy in the median nerve. Although subjects with persistent IGT had higher HbA(1c), vibrotactile sensation and electrophysiology remained normal. HbA(1c) did not correlate with vibrotactile sense or electrophysiology, but the latter two correlated with respect to Z-score (sign of neuropathy) in forearm (NGT) and at wrist level (NGT and DM). Conclusions Vibration thresholds are increased in the finger pulps in T2DM subjects, particularly at specific frequencies in ulnar nerve innervated finger pulps. Neuropathy is not present in IGT. Tactilometry, with a multi-frequency approach, is a sensitive technique to screen for large fibre neuropathy in T2DM. Frequency-related changes may mirror dysfunction of various receptors. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetic medicine : a journal of the British Diabetic Association
volume
25
pages
543 - 549
publisher
Wiley-Blackwell
external identifiers
  • PMID:18346156
  • WOS:000255285600005
  • Scopus:42549104559
ISSN
1464-5491
DOI
10.1111/j.1464-5491.2008.02433.x
language
English
LU publication?
yes
id
a8e3c608-6ba2-424a-81b1-a07af3c7930a (old id 1052386)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18346156?dopt=Abstract
date added to LUP
2008-04-01 10:51:22
date last changed
2016-10-27 16:12:25
@misc{a8e3c608-6ba2-424a-81b1-a07af3c7930a,
  abstract     = {Aims To investigate vibrotactile sense (large fibre neuropathy) at different frequencies in index and little fingers (median and ulnar nerves, respectively) of subjects with diabetes, or impaired (IGT) or normal glucose tolerance (NGT). Methods Vibration thresholds (tactilometry at seven frequencies (8, 16, 32, 64, 125, 250 and 500 Hz)) and median nerve function (electrophysiology) were examined in men (age 73.4 +/- 0.12 years; n = 58, mean +/- sd) with persistent NGT (n = 28) or IGT (n = 7) or with Type 2 diabetes mellitus (T2DM) (n = 23) for > 15 years. Results HbA(1c) was increased and vibrotactile sense (sensibility index) was impaired in index and little fingers in men with T2DM. Vibration thresholds were particularly increased at 16, 250 and 500 Hz in the little finger (ulnar nerve). T2DM subjects showed electrophysiological (gold standard) signs of neuropathy in the median nerve. Although subjects with persistent IGT had higher HbA(1c), vibrotactile sensation and electrophysiology remained normal. HbA(1c) did not correlate with vibrotactile sense or electrophysiology, but the latter two correlated with respect to Z-score (sign of neuropathy) in forearm (NGT) and at wrist level (NGT and DM). Conclusions Vibration thresholds are increased in the finger pulps in T2DM subjects, particularly at specific frequencies in ulnar nerve innervated finger pulps. Neuropathy is not present in IGT. Tactilometry, with a multi-frequency approach, is a sensitive technique to screen for large fibre neuropathy in T2DM. Frequency-related changes may mirror dysfunction of various receptors.},
  author       = {Dahlin, Lars and Thrainsdottir, Soley and Cederlund, Ragnhild and Thomsen, Niels and Eriksson, Karl-Fredrik and Rosén, Ingmar and Speidel, T and Sundqvist, G},
  issn         = {1464-5491},
  language     = {eng},
  pages        = {543--549},
  publisher    = {ARRAY(0x99341a8)},
  series       = {Diabetic medicine : a journal of the British Diabetic Association},
  title        = {Vibrotactile sense in median and ulnar nerve innervated fingers of men with Type 2 diabetes, normal or impaired glucose tolerance.},
  url          = {http://dx.doi.org/10.1111/j.1464-5491.2008.02433.x},
  volume       = {25},
  year         = {2008},
}