Vibrotactile sense in median and ulnar nerve innervated fingers of men with Type 2 diabetes, normal or impaired glucose tolerance.
Dahlin, Lars LU
; Thrainsdottir, Soley
LU
; Cederlund, Ragnhild
LU
; Thomsen, Niels
LU
; Eriksson, Karl-Fredrik
LU
; Rosén, Ingmar
LU
; Speidel, T
and Sundqvist, G
(2008)
In Diabetic Medicine: A journal of the British Diabetic Association
25.
p.543-549
- Abstract
- Aims To investigate vibrotactile sense (large fibre neuropathy) at different frequencies in index and little fingers (median and ulnar nerves, respectively) of subjects with diabetes, or impaired (IGT) or normal glucose tolerance (NGT). Methods Vibration thresholds (tactilometry at seven frequencies (8, 16, 32, 64, 125, 250 and 500 Hz)) and median nerve function (electrophysiology) were examined in men (age 73.4 +/- 0.12 years; n = 58, mean +/- sd) with persistent NGT (n = 28) or IGT (n = 7) or with Type 2 diabetes mellitus (T2DM) (n = 23) for > 15 years. Results HbA(1c) was increased and vibrotactile sense (sensibility index) was impaired in index and little fingers in men with T2DM. Vibration thresholds were particularly increased at... (More)
- Aims To investigate vibrotactile sense (large fibre neuropathy) at different frequencies in index and little fingers (median and ulnar nerves, respectively) of subjects with diabetes, or impaired (IGT) or normal glucose tolerance (NGT). Methods Vibration thresholds (tactilometry at seven frequencies (8, 16, 32, 64, 125, 250 and 500 Hz)) and median nerve function (electrophysiology) were examined in men (age 73.4 +/- 0.12 years; n = 58, mean +/- sd) with persistent NGT (n = 28) or IGT (n = 7) or with Type 2 diabetes mellitus (T2DM) (n = 23) for > 15 years. Results HbA(1c) was increased and vibrotactile sense (sensibility index) was impaired in index and little fingers in men with T2DM. Vibration thresholds were particularly increased at 16, 250 and 500 Hz in the little finger (ulnar nerve). T2DM subjects showed electrophysiological (gold standard) signs of neuropathy in the median nerve. Although subjects with persistent IGT had higher HbA(1c), vibrotactile sensation and electrophysiology remained normal. HbA(1c) did not correlate with vibrotactile sense or electrophysiology, but the latter two correlated with respect to Z-score (sign of neuropathy) in forearm (NGT) and at wrist level (NGT and DM). Conclusions Vibration thresholds are increased in the finger pulps in T2DM subjects, particularly at specific frequencies in ulnar nerve innervated finger pulps. Neuropathy is not present in IGT. Tactilometry, with a multi-frequency approach, is a sensitive technique to screen for large fibre neuropathy in T2DM. Frequency-related changes may mirror dysfunction of various receptors. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1052386
- author
- Dahlin, Lars
LU
; Thrainsdottir, Soley
LU
; Cederlund, Ragnhild
LU
; Thomsen, Niels
LU
; Eriksson, Karl-Fredrik
LU
; Rosén, Ingmar
LU
; Speidel, T
and Sundqvist, G
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetic Medicine: A journal of the British Diabetic Association
- volume
- 25
- pages
- 543 - 549
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:18346156
- wos:000255285600005
- scopus:42549104559
- ISSN
- 1464-5491
- DOI
- 10.1111/j.1464-5491.2008.02433.x
- project
- Diabetic neuropathy and nerve compression in diabetes
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Hand Surgery Research Group (013241910), Reconstructive Surgery (013240300), Clinical Neurophysiology (013013001), Neurology, Malmö (013027010), Unit for Clinical Vascular Disease Research (013242410), Division of Occupational Therapy (Closed 2012) (013025000)
- id
- a8e3c608-6ba2-424a-81b1-a07af3c7930a (old id 1052386)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18346156?dopt=Abstract
- date added to LUP
- 2016-04-04 09:25:04
- date last changed
- 2022-03-23 05:25:53
@article{a8e3c608-6ba2-424a-81b1-a07af3c7930a,
abstract = {{Aims To investigate vibrotactile sense (large fibre neuropathy) at different frequencies in index and little fingers (median and ulnar nerves, respectively) of subjects with diabetes, or impaired (IGT) or normal glucose tolerance (NGT). Methods Vibration thresholds (tactilometry at seven frequencies (8, 16, 32, 64, 125, 250 and 500 Hz)) and median nerve function (electrophysiology) were examined in men (age 73.4 +/- 0.12 years; n = 58, mean +/- sd) with persistent NGT (n = 28) or IGT (n = 7) or with Type 2 diabetes mellitus (T2DM) (n = 23) for > 15 years. Results HbA(1c) was increased and vibrotactile sense (sensibility index) was impaired in index and little fingers in men with T2DM. Vibration thresholds were particularly increased at 16, 250 and 500 Hz in the little finger (ulnar nerve). T2DM subjects showed electrophysiological (gold standard) signs of neuropathy in the median nerve. Although subjects with persistent IGT had higher HbA(1c), vibrotactile sensation and electrophysiology remained normal. HbA(1c) did not correlate with vibrotactile sense or electrophysiology, but the latter two correlated with respect to Z-score (sign of neuropathy) in forearm (NGT) and at wrist level (NGT and DM). Conclusions Vibration thresholds are increased in the finger pulps in T2DM subjects, particularly at specific frequencies in ulnar nerve innervated finger pulps. Neuropathy is not present in IGT. Tactilometry, with a multi-frequency approach, is a sensitive technique to screen for large fibre neuropathy in T2DM. Frequency-related changes may mirror dysfunction of various receptors.}},
author = {{Dahlin, Lars and Thrainsdottir, Soley and Cederlund, Ragnhild and Thomsen, Niels and Eriksson, Karl-Fredrik and Rosén, Ingmar and Speidel, T and Sundqvist, G}},
issn = {{1464-5491}},
language = {{eng}},
pages = {{543--549}},
publisher = {{Wiley-Blackwell}},
series = {{Diabetic Medicine: A journal of the British Diabetic Association}},
title = {{Vibrotactile sense in median and ulnar nerve innervated fingers of men with Type 2 diabetes, normal or impaired glucose tolerance.}},
url = {{https://lup.lub.lu.se/search/files/5318626/1057210.pdf}},
doi = {{10.1111/j.1464-5491.2008.02433.x}},
volume = {{25}},
year = {{2008}},
}