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Changes in forearm bone mass and bone size after menopause - A mean 24-year prospective study.

Svejme, Ola LU ; Ahlborg, Henrik LU and Karlsson, Magnus LU (2012) In Journal of Musculoskeletal and Neuronal Interactions - Jmni 12(4). p.192-198
Abstract
Objective: Bone loss and periosteal expansion is found after menopause. The accelerated early postmenopausal bone loss is not permanent but if the same accounts for the periosteal expansion is unknown. Methods: Bone mineral density (BMD) and skeletal structure of the distal forearm were followed from menopause and on average 24 years (range 18-28) by single-photon absorptiometry at 12 occasions in a population-based sample of 81 Caucasian women with no medication or disease affecting bone metabolism. A Strength Index based on areal BMD and bone structure was calculated. Postmenopausal serum-estradiol levels and incident distal radius fractures were registered. Data are presented as means with 95% confidence interval (95% CI). Results: The... (More)
Objective: Bone loss and periosteal expansion is found after menopause. The accelerated early postmenopausal bone loss is not permanent but if the same accounts for the periosteal expansion is unknown. Methods: Bone mineral density (BMD) and skeletal structure of the distal forearm were followed from menopause and on average 24 years (range 18-28) by single-photon absorptiometry at 12 occasions in a population-based sample of 81 Caucasian women with no medication or disease affecting bone metabolism. A Strength Index based on areal BMD and bone structure was calculated. Postmenopausal serum-estradiol levels and incident distal radius fractures were registered. Data are presented as means with 95% confidence interval (95% CI). Results: The annual BMD loss in three periods, 0-8, 8-16 and 16-28 years after menopause, was 2.0% (1.6, 2.4), 1.0% (0.6, 1.4) and 1.0% (0.7, 1.3), respectively. The annual periosteal expansion was 1.0% (0.8, 1.3), 0.0% (-0.3, 0.3) and 0.0% (-0.2, 0.2), respectively. Mean post-menopausal oestrogen levels correlated moderately with annual loss in aBMD (r=0.51, p<0.001) but less with the annual changes in bone width (r= -0.22, p=0.06). Conclusion: Postmenopausal periosteal expansion in the distal forearm seems to occur only in the first postmenopausal decade. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Journal of Musculoskeletal and Neuronal Interactions - Jmni
volume
12
issue
4
pages
192 - 198
publisher
International Society of Musculoskeletal and Neuronal Interactions
external identifiers
  • WOS:000313419100001
  • PMID:23196261
  • Scopus:84870825899
ISSN
1108-7161
language
English
LU publication?
yes
id
a2dd1cca-07f7-4e44-893b-828760e83941 (old id 3347833)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23196261?dopt=Abstract
date added to LUP
2013-01-02 10:27:56
date last changed
2016-10-13 04:30:19
@misc{a2dd1cca-07f7-4e44-893b-828760e83941,
  abstract     = {Objective: Bone loss and periosteal expansion is found after menopause. The accelerated early postmenopausal bone loss is not permanent but if the same accounts for the periosteal expansion is unknown. Methods: Bone mineral density (BMD) and skeletal structure of the distal forearm were followed from menopause and on average 24 years (range 18-28) by single-photon absorptiometry at 12 occasions in a population-based sample of 81 Caucasian women with no medication or disease affecting bone metabolism. A Strength Index based on areal BMD and bone structure was calculated. Postmenopausal serum-estradiol levels and incident distal radius fractures were registered. Data are presented as means with 95% confidence interval (95% CI). Results: The annual BMD loss in three periods, 0-8, 8-16 and 16-28 years after menopause, was 2.0% (1.6, 2.4), 1.0% (0.6, 1.4) and 1.0% (0.7, 1.3), respectively. The annual periosteal expansion was 1.0% (0.8, 1.3), 0.0% (-0.3, 0.3) and 0.0% (-0.2, 0.2), respectively. Mean post-menopausal oestrogen levels correlated moderately with annual loss in aBMD (r=0.51, p&lt;0.001) but less with the annual changes in bone width (r= -0.22, p=0.06). Conclusion: Postmenopausal periosteal expansion in the distal forearm seems to occur only in the first postmenopausal decade.},
  author       = {Svejme, Ola and Ahlborg, Henrik and Karlsson, Magnus},
  issn         = {1108-7161},
  language     = {eng},
  number       = {4},
  pages        = {192--198},
  publisher    = {ARRAY(0x895efc8)},
  series       = {Journal of Musculoskeletal and Neuronal Interactions - Jmni},
  title        = {Changes in forearm bone mass and bone size after menopause - A mean 24-year prospective study.},
  volume       = {12},
  year         = {2012},
}