Overall cancer incidence not increased after prosthetic knee replacement : 14,551 patients followed for 66,622 person-years
(1996) In International Journal of Cancer 68(1). p.3-30- Abstract
It is unknown whether patients as a consequence of prosthetic joint replacement are at a higher risk of developing cancer. We therefore analyzed cancer incidence following prosthetic knee replacement (TKR). The observed cancer incidence in 14,551 patients from the population-based Swedish Knee Arthroplasty Register who have undergone TKR because of osteoarthrosis (OA, n = 10,120) or rheumatoid arthritis (RA, n = 4431) were compared with the expected cancer incidence for a Swedish reference population. The cohort was followed for a total of 66,622 person-years. We followed 33% of the patients with OA and 59% of those with RA for more than 5 years. All patients who underwent TKR, whether for OA or for RA, had lower than expected total... (More)
It is unknown whether patients as a consequence of prosthetic joint replacement are at a higher risk of developing cancer. We therefore analyzed cancer incidence following prosthetic knee replacement (TKR). The observed cancer incidence in 14,551 patients from the population-based Swedish Knee Arthroplasty Register who have undergone TKR because of osteoarthrosis (OA, n = 10,120) or rheumatoid arthritis (RA, n = 4431) were compared with the expected cancer incidence for a Swedish reference population. The cohort was followed for a total of 66,622 person-years. We followed 33% of the patients with OA and 59% of those with RA for more than 5 years. All patients who underwent TKR, whether for OA or for RA, had lower than expected total cancer incidence. We found a markedly low incidence of colorectal carcinoma, especially in patients with RA. Our results do not indicate an increased incidence of cancer following TKR.
(Less)
- author
- Lewold, S LU ; Olsson, Håkan LU ; Gustafson, P LU ; Rydholm, A LU and Lidgren, L LU
- organization
- publishing date
- 1996-09-27
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Arthritis, Rheumatoid, Colorectal Neoplasms, Female, Humans, Knee Prosthesis, Male, Neoplasms, Osteoarthritis, Sweden, Time Factors
- in
- International Journal of Cancer
- volume
- 68
- issue
- 1
- pages
- 4 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:0029853570
- pmid:8895536
- ISSN
- 0020-7136
- DOI
- 10.1002/(SICI)1097-0215(19960927)68:1<30::AID-IJC6>3.0.CO;2-Y
- language
- English
- LU publication?
- yes
- id
- 403425a1-8626-4410-a168-038a1fed6f27
- date added to LUP
- 2016-09-18 12:50:53
- date last changed
- 2024-01-04 12:33:41
@article{403425a1-8626-4410-a168-038a1fed6f27, abstract = {{<p>It is unknown whether patients as a consequence of prosthetic joint replacement are at a higher risk of developing cancer. We therefore analyzed cancer incidence following prosthetic knee replacement (TKR). The observed cancer incidence in 14,551 patients from the population-based Swedish Knee Arthroplasty Register who have undergone TKR because of osteoarthrosis (OA, n = 10,120) or rheumatoid arthritis (RA, n = 4431) were compared with the expected cancer incidence for a Swedish reference population. The cohort was followed for a total of 66,622 person-years. We followed 33% of the patients with OA and 59% of those with RA for more than 5 years. All patients who underwent TKR, whether for OA or for RA, had lower than expected total cancer incidence. We found a markedly low incidence of colorectal carcinoma, especially in patients with RA. Our results do not indicate an increased incidence of cancer following TKR.</p>}}, author = {{Lewold, S and Olsson, Håkan and Gustafson, P and Rydholm, A and Lidgren, L}}, issn = {{0020-7136}}, keywords = {{Arthritis, Rheumatoid; Colorectal Neoplasms; Female; Humans; Knee Prosthesis; Male; Neoplasms; Osteoarthritis; Sweden; Time Factors}}, language = {{eng}}, month = {{09}}, number = {{1}}, pages = {{3--30}}, publisher = {{John Wiley & Sons Inc.}}, series = {{International Journal of Cancer}}, title = {{Overall cancer incidence not increased after prosthetic knee replacement : 14,551 patients followed for 66,622 person-years}}, url = {{http://dx.doi.org/10.1002/(SICI)1097-0215(19960927)68:1<30::AID-IJC6>3.0.CO;2-Y}}, doi = {{10.1002/(SICI)1097-0215(19960927)68:1<30::AID-IJC6>3.0.CO;2-Y}}, volume = {{68}}, year = {{1996}}, }