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RIFM fragrance ingredient safety assessment, isoamyl salicylate, CAS registry number 87-20-7.

Api, A M; Belsito, D; Bhatia, S; Bruze, Magnus LU ; Calow, P; Dagli, M L; Dekant, W; Fryer, A D; Kromidas, L and La Cava, S, et al. (2015) In Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Abstract
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined using to have the most conservative systemic exposure derived NOAEL of 47 mg/kg/day. A dietary 13-week subchronic toxicity study conducted in rats on a suitable read across analog resulted in a MOE of 2350 while considering 10.3% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.
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published
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
publisher
Elsevier
external identifiers
  • PMID:26419451
  • Scopus:84955402049
ISSN
1873-6351
DOI
10.1016/j.fct.2015.09.014
language
English
LU publication?
yes
id
77f86c6a-49ce-4afa-be21-4b8c34ccdf65 (old id 8159988)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26419451?dopt=Abstract
date added to LUP
2015-11-02 10:49:55
date last changed
2016-10-13 04:25:45
@misc{77f86c6a-49ce-4afa-be21-4b8c34ccdf65,
  abstract     = {The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined using to have the most conservative systemic exposure derived NOAEL of 47 mg/kg/day. A dietary 13-week subchronic toxicity study conducted in rats on a suitable read across analog resulted in a MOE of 2350 while considering 10.3% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.},
  author       = {Api, A M and Belsito, D and Bhatia, S and Bruze, Magnus and Calow, P and Dagli, M L and Dekant, W and Fryer, A D and Kromidas, L and La Cava, S and Lalko, J F and Lapczynski, A and Liebler, D C and Miyachi, Y and Politano, V T and Ritacco, G and Salvito, D and Schultz, T W and Shen, J and Sipes, I G and Wall, B and Wilcox, D K},
  issn         = {1873-6351},
  language     = {eng},
  month        = {09},
  publisher    = {ARRAY(0x90dd3c0)},
  series       = {Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  title        = {RIFM fragrance ingredient safety assessment, isoamyl salicylate, CAS registry number 87-20-7.},
  url          = {http://dx.doi.org/10.1016/j.fct.2015.09.014},
  year         = {2015},
}