Low-grade inflammation, oxidative stress and risk of invasive post-menopausal breast cancer - A nested case-control study from the Malmö diet and cancer cohort
(2016) In PLoS ONE 11(7).- Abstract
Objective: Although cancer promotes inflammation, the role of inflammation in tumor-genesis is less well established. The aim was to examine if low-grade inflammation is related to post-menopausal breast cancer risk, and if obesity modifies this association. Methods; In the Malmo Diet and Cancer cohort, a nested case-control study was defined among 8,513 women free of cancer and aged 55.73 years at baseline (1991.96); 459 were diagnosed with invasive breast cancer during follow-up (until December 31st, 2010). In laboratory analyses of blood from 446 cases, and 885 controls (matched on age and date of blood sampling) we examined systemic inflammation markers: oxidized (ox)-LDL, interleukin (IL)- 1β, IL-6, IL-8, tumor necrosis... (More)
Objective: Although cancer promotes inflammation, the role of inflammation in tumor-genesis is less well established. The aim was to examine if low-grade inflammation is related to post-menopausal breast cancer risk, and if obesity modifies this association. Methods; In the Malmo Diet and Cancer cohort, a nested case-control study was defined among 8,513 women free of cancer and aged 55.73 years at baseline (1991.96); 459 were diagnosed with invasive breast cancer during follow-up (until December 31st, 2010). In laboratory analyses of blood from 446 cases, and 885 controls (matched on age and date of blood sampling) we examined systemic inflammation markers: oxidized (ox)-LDL, interleukin (IL)- 1β, IL-6, IL-8, tumor necrosis factor (TNF)-α, white blood cells, lymphocytes and neutrophils. Odds ratios (OR) and 95% confidence intervals (CI) for breast cancer risk was calculated using multivariable conditional logistic regression. Results: Inverse associations with breast cancer were seen in fully-adjusted models, for 2nd and 3rd tertiles of ox-LDL, OR (95% CI): 0.65 (0.47.0.90), 0.63 (0.45.0.89) respectively, p-trend = 0.01; and for the 3rd tertile of TNF-α, 0.65 (0.43.0.99), p-trend = 0.04. In contrast, those in the highest IL-1β category had higher risk, 1.71 (1.05.2.79), p-trend = 0.01. Obesity did not modify associations between inflammation biomarkers and breast cancer. Conclusion; Our study does not suggest that low-grade inflammation increase the risk of post-menopausal breast cancer.
(Less)
- author
- Alves Dias, Joana LU ; Nordin Fredrikson, Gunilla LU ; Ericson, Ulrika LU ; Gullberg, Bo LU ; Hedblad, Bo LU ; Engström, Gunnar LU ; Borgquist, Signe LU ; Nilsson, Jan LU and Wirfält, Elisabet LU
- organization
-
- EXODIAB: Excellence of Diabetes Research in Sweden
- EpiHealth: Epidemiology for Health
- Nutrition Epidemiology (research group)
- Cardiovascular Research - Immunity and Atherosclerosis (research group)
- Diabetes - Cardiovascular Disease (research group)
- Cardiovascular Research - Epidemiology (research group)
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
- Breastcancer-genetics
- publishing date
- 2016-07-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 11
- issue
- 7
- article number
- e0158959
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- scopus:84978906361
- pmid:27391324
- wos:000380005400173
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0158959
- language
- English
- LU publication?
- yes
- id
- 8ea3bde5-0f3e-495f-88f5-7e46b7e508b5
- date added to LUP
- 2016-08-17 16:12:01
- date last changed
- 2024-09-20 21:26:58
@article{8ea3bde5-0f3e-495f-88f5-7e46b7e508b5, abstract = {{<p>Objective: Although cancer promotes inflammation, the role of inflammation in tumor-genesis is less well established. The aim was to examine if low-grade inflammation is related to post-menopausal breast cancer risk, and if obesity modifies this association. Methods; In the Malmo Diet and Cancer cohort, a nested case-control study was defined among 8,513 women free of cancer and aged 55.73 years at baseline (1991.96); 459 were diagnosed with invasive breast cancer during follow-up (until December 31<sup>st</sup>, 2010). In laboratory analyses of blood from 446 cases, and 885 controls (matched on age and date of blood sampling) we examined systemic inflammation markers: oxidized (ox)-LDL, interleukin (IL)- 1β, IL-6, IL-8, tumor necrosis factor (TNF)-α, white blood cells, lymphocytes and neutrophils. Odds ratios (OR) and 95% confidence intervals (CI) for breast cancer risk was calculated using multivariable conditional logistic regression. Results: Inverse associations with breast cancer were seen in fully-adjusted models, for 2<sup>nd</sup> and 3<sup>rd</sup> tertiles of ox-LDL, OR (95% CI): 0.65 (0.47.0.90), 0.63 (0.45.0.89) respectively, p-trend = 0.01; and for the 3<sup>rd</sup> tertile of TNF-α, 0.65 (0.43.0.99), p-trend = 0.04. In contrast, those in the highest IL-1β category had higher risk, 1.71 (1.05.2.79), p-trend = 0.01. Obesity did not modify associations between inflammation biomarkers and breast cancer. Conclusion; Our study does not suggest that low-grade inflammation increase the risk of post-menopausal breast cancer.</p>}}, author = {{Alves Dias, Joana and Nordin Fredrikson, Gunilla and Ericson, Ulrika and Gullberg, Bo and Hedblad, Bo and Engström, Gunnar and Borgquist, Signe and Nilsson, Jan and Wirfält, Elisabet}}, issn = {{1932-6203}}, language = {{eng}}, month = {{07}}, number = {{7}}, publisher = {{Public Library of Science (PLoS)}}, series = {{PLoS ONE}}, title = {{Low-grade inflammation, oxidative stress and risk of invasive post-menopausal breast cancer - A nested case-control study from the Malmö diet and cancer cohort}}, url = {{http://dx.doi.org/10.1371/journal.pone.0158959}}, doi = {{10.1371/journal.pone.0158959}}, volume = {{11}}, year = {{2016}}, }