Interleukin-1 receptor accessory protein (IL-1RAP) : A magic bullet candidate for immunotherapy of human malignancies
(2024) In Critical Reviews in Oncology/Hematology 193.- Abstract
IL-1, plays a role in some pathological inflammatory conditions. This pro-inflammatory cytokine also has a crucial role in tumorigenesis and immune responses in the tumor microenvironment (TME). IL-1 receptor accessory protein (IL-1RAP), combined with IL-1 receptor-1, provides a functional complex for binding and signaling. In addition to the direct role of IL-1, some studies demonstrated that IL1-RAP has essential roles in the progression, angiogenesis, and metastasis of solid tumors such as gastrointestinal tumors, lung carcinoma, glioma, breast and cervical cancers. This molecule also interacts with FLT-3 and c-Kit tyrosine kinases and is involved in the pathogenesis of hematological malignancies such as acute myeloid lymphoma.... (More)
IL-1, plays a role in some pathological inflammatory conditions. This pro-inflammatory cytokine also has a crucial role in tumorigenesis and immune responses in the tumor microenvironment (TME). IL-1 receptor accessory protein (IL-1RAP), combined with IL-1 receptor-1, provides a functional complex for binding and signaling. In addition to the direct role of IL-1, some studies demonstrated that IL1-RAP has essential roles in the progression, angiogenesis, and metastasis of solid tumors such as gastrointestinal tumors, lung carcinoma, glioma, breast and cervical cancers. This molecule also interacts with FLT-3 and c-Kit tyrosine kinases and is involved in the pathogenesis of hematological malignancies such as acute myeloid lymphoma. Additionally, IL-1RAP interacts with solute carrier family 3 member 2 (SLC3A2) and thereby increasing the resistance to anoikis and metastasis in Ewing sarcoma. This review summarizes the role of IL-1RAP in different types of cancers and discusses its targeting as a novel therapeutic approach for malignancies.
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- author
- Zarezadeh Mehrabadi, Ali ; Shahba, Faezeh ; Khorramdelazad, Hossein ; Aghamohammadi, Nazanin ; Karimi, Milad ; Bagherzadeh, Kowsar ; Khoshmirsafa, Majid ; Massoumi, Ramin LU and Falak, Reza
- organization
- publishing date
- 2024-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cancer immunotherapy, Chronic inflammation, IL-1 receptor accessory protein, Interleukin-1
- in
- Critical Reviews in Oncology/Hematology
- volume
- 193
- article number
- 104200
- publisher
- Elsevier
- external identifiers
-
- pmid:37981104
- scopus:85178258445
- ISSN
- 1040-8428
- DOI
- 10.1016/j.critrevonc.2023.104200
- language
- English
- LU publication?
- yes
- id
- 02b89c8e-5b01-4d18-b026-6accc9af219f
- date added to LUP
- 2023-12-18 14:27:31
- date last changed
- 2024-08-07 12:48:15
@article{02b89c8e-5b01-4d18-b026-6accc9af219f, abstract = {{<p>IL-1, plays a role in some pathological inflammatory conditions. This pro-inflammatory cytokine also has a crucial role in tumorigenesis and immune responses in the tumor microenvironment (TME). IL-1 receptor accessory protein (IL-1RAP), combined with IL-1 receptor-1, provides a functional complex for binding and signaling. In addition to the direct role of IL-1, some studies demonstrated that IL1-RAP has essential roles in the progression, angiogenesis, and metastasis of solid tumors such as gastrointestinal tumors, lung carcinoma, glioma, breast and cervical cancers. This molecule also interacts with FLT-3 and c-Kit tyrosine kinases and is involved in the pathogenesis of hematological malignancies such as acute myeloid lymphoma. Additionally, IL-1RAP interacts with solute carrier family 3 member 2 (SLC3A2) and thereby increasing the resistance to anoikis and metastasis in Ewing sarcoma. This review summarizes the role of IL-1RAP in different types of cancers and discusses its targeting as a novel therapeutic approach for malignancies.</p>}}, author = {{Zarezadeh Mehrabadi, Ali and Shahba, Faezeh and Khorramdelazad, Hossein and Aghamohammadi, Nazanin and Karimi, Milad and Bagherzadeh, Kowsar and Khoshmirsafa, Majid and Massoumi, Ramin and Falak, Reza}}, issn = {{1040-8428}}, keywords = {{Cancer immunotherapy; Chronic inflammation; IL-1 receptor accessory protein; Interleukin-1}}, language = {{eng}}, publisher = {{Elsevier}}, series = {{Critical Reviews in Oncology/Hematology}}, title = {{Interleukin-1 receptor accessory protein (IL-1RAP) : A magic bullet candidate for immunotherapy of human malignancies}}, url = {{http://dx.doi.org/10.1016/j.critrevonc.2023.104200}}, doi = {{10.1016/j.critrevonc.2023.104200}}, volume = {{193}}, year = {{2024}}, }