Coronary flow and reactivity, but not arrhythmia vulnerability, are affected by cardioplegia during cardiopulmonary bypass surgery of piglets
Liuba, P. LU ; Johansson, Sune LU ; Pesonen, E. LU ; Higgins, Thomas ; Forslid, A. LU
; Kornerup-Hansen, Axel
and Perez De Sa, V.
LU
(2011)
45th Annual Meeting of the European Paediatric Cardiology
In Cardiology in the Young
21(S1).
p.70-70
- Abstract
- Introduction: Cardiopulmonary bypass (CPB) surgery remains associated with significant cardiovascular morbidity in both pediatric and adult patients but the mechanisms are not fully clarified. Abnormalities in coronary flow and function have beensuggested to play an important role. A few prior studies suggested protective effects on coronary and myocardial function by short intravenous (i.v.) infusion of cyclosporine A prior to CPB surgery. Methods: Barrier-bred piglets (10-12 kg, n=20) were subjected to CPB with (n=10) or without (n=10) antegrade administration for 20 minutes of cardioplegic solution. Prior to surgery, half of animals from each group received 10-minute i.v. infusion of 100 mg/kg cyclosporine A. Left anterior descending... (More)
- Introduction: Cardiopulmonary bypass (CPB) surgery remains associated with significant cardiovascular morbidity in both pediatric and adult patients but the mechanisms are not fully clarified. Abnormalities in coronary flow and function have beensuggested to play an important role. A few prior studies suggested protective effects on coronary and myocardial function by short intravenous (i.v.) infusion of cyclosporine A prior to CPB surgery. Methods: Barrier-bred piglets (10-12 kg, n=20) were subjected to CPB with (n=10) or without (n=10) antegrade administration for 20 minutes of cardioplegic solution. Prior to surgery, half of animals from each group received 10-minute i.v. infusion of 100 mg/kg cyclosporine A. Left anterior descending coronary flow velocity responses to adenosine, serotonin, and atrial pacing, as well as left ventricular function and postsurgical vulnerability to atrial fibrillation (Afib) were assessed by intracoronary Doppler, epicardial echocardiography, and in vivo electrophysiological study, respectively. Results: Coronary peak flow velocity (cPFV) rose significantly after surgery, especially in cardioplegia group (p0.4). There was no difference in systolic myocardial function between groups at any timepoint. Conclusions: Cardioplegia during CPB surgery of piglets was associated with profound abnormalities in coronary vasomotor tone and receptor-related flow regulation, whereas arrhythmia vulnerability appeared to be comparable with that in non-cardioplegia group. In this study, intracoronary pretreatment with cyclosporine had no observable protective effect on coronary circulation or arrhythmia vulnerability after CPB surgery. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/0715d3de-dfde-48f1-bf5c-c2be32998651
- author
- Liuba, P.
LU
; Johansson, Sune
LU
; Pesonen, E.
LU
; Higgins, Thomas
; Forslid, A.
LU
; Kornerup-Hansen, Axel
and Perez De Sa, V.
LU
- organization
- publishing date
- 2011-05-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cyclosporin, serotonin, adenosine, cyclosporin A, receptor, cardioplegic agent, cardioplegia, bypass surgery, Japanese (people), coronary artery blood flow, cardiopulmonary bypass, heart arrhythmia, society, piglet, cardiology, heart surgery, pediatric cardiology, surgery, flow rate, heart atrium pacing, heart function, infusion, morbidity, heart left ventricle function, atrial fibrillation, adult, patient, peak expiratory flow, echocardiography, intravenous drug administration
- in
- Cardiology in the Young
- volume
- 21
- issue
- S1
- article number
- P-47
- pages
- 70 - 70
- publisher
- Cambridge University Press
- conference name
- 45th Annual Meeting of the European Paediatric Cardiology
- conference location
- Granada, Spain
- conference dates
- 2011-05-18 - 2011-05-21
- ISSN
- 1467-1107
- DOI
- 10.1017/S104795111100028X
- language
- English
- LU publication?
- yes
- id
- 0715d3de-dfde-48f1-bf5c-c2be32998651
- date added to LUP
- 2017-07-21 10:25:41
- date last changed
- 2018-11-21 21:33:30
@misc{0715d3de-dfde-48f1-bf5c-c2be32998651,
abstract = {{Introduction: Cardiopulmonary bypass (CPB) surgery remains associated with significant cardiovascular morbidity in both pediatric and adult patients but the mechanisms are not fully clarified. Abnormalities in coronary flow and function have beensuggested to play an important role. A few prior studies suggested protective effects on coronary and myocardial function by short intravenous (i.v.) infusion of cyclosporine A prior to CPB surgery. Methods: Barrier-bred piglets (10-12 kg, n=20) were subjected to CPB with (n=10) or without (n=10) antegrade administration for 20 minutes of cardioplegic solution. Prior to surgery, half of animals from each group received 10-minute i.v. infusion of 100 mg/kg cyclosporine A. Left anterior descending coronary flow velocity responses to adenosine, serotonin, and atrial pacing, as well as left ventricular function and postsurgical vulnerability to atrial fibrillation (Afib) were assessed by intracoronary Doppler, epicardial echocardiography, and in vivo electrophysiological study, respectively. Results: Coronary peak flow velocity (cPFV) rose significantly after surgery, especially in cardioplegia group (p0.4). There was no difference in systolic myocardial function between groups at any timepoint. Conclusions: Cardioplegia during CPB surgery of piglets was associated with profound abnormalities in coronary vasomotor tone and receptor-related flow regulation, whereas arrhythmia vulnerability appeared to be comparable with that in non-cardioplegia group. In this study, intracoronary pretreatment with cyclosporine had no observable protective effect on coronary circulation or arrhythmia vulnerability after CPB surgery.}},
author = {{Liuba, P. and Johansson, Sune and Pesonen, E. and Higgins, Thomas and Forslid, A. and Kornerup-Hansen, Axel and Perez De Sa, V.}},
issn = {{1467-1107}},
keywords = {{cyclosporin; serotonin; adenosine; cyclosporin A; receptor; cardioplegic agent; cardioplegia; bypass surgery; Japanese (people); coronary artery blood flow; cardiopulmonary bypass; heart arrhythmia; society; piglet; cardiology; heart surgery; pediatric cardiology; surgery; flow rate; heart atrium pacing; heart function; infusion; morbidity; heart left ventricle function; atrial fibrillation; adult; patient; peak expiratory flow; echocardiography; intravenous drug administration}},
language = {{eng}},
month = {{05}},
note = {{Conference Abstract}},
number = {{S1}},
pages = {{70--70}},
publisher = {{Cambridge University Press}},
series = {{Cardiology in the Young}},
title = {{Coronary flow and reactivity, but not arrhythmia vulnerability, are affected by cardioplegia during cardiopulmonary bypass surgery of piglets}},
url = {{http://dx.doi.org/10.1017/S104795111100028X}},
doi = {{10.1017/S104795111100028X}},
volume = {{21}},
year = {{2011}},
}