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Parkinson disease and growth factors — is GDNF good enough?

Kirkeby, Agnete LU and Barker, Roger LU (2019) In Nature Reviews Neurology 15. p.312-312
Abstract
Previous open-label trials testing glial cell line-derived neurotrophic factor (GDNF) family ligands in Parkinson disease have shown promising clinical effects. However, in placebo-controlled trials, the treatments have failed. A new randomized placebo-controlled trial of intraputamenal delivery of GDNF designed to resolve this conundrum has again failed to do just that.
Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Reviews Neurology
volume
15
pages
314 pages
publisher
Nature Publishing Group
external identifiers
  • pmid:30948845
  • scopus:85064011594
ISSN
1759-4766
DOI
10.1038/s41582-019-0180-6
language
English
LU publication?
no
id
076d6a52-1fe1-4b9b-862a-5aeb0358d032
alternative location
https://www.nature.com/articles/s41582-019-0180-6
date added to LUP
2019-11-28 13:24:52
date last changed
2025-10-17 13:57:11
@misc{076d6a52-1fe1-4b9b-862a-5aeb0358d032,
  abstract     = {{Previous open-label trials testing glial cell line-derived neurotrophic factor (GDNF) family ligands in Parkinson disease have shown promising clinical effects. However, in placebo-controlled trials, the treatments have failed. A new randomized placebo-controlled trial of intraputamenal delivery of GDNF designed to resolve this conundrum has again failed to do just that.}},
  author       = {{Kirkeby, Agnete and Barker, Roger}},
  issn         = {{1759-4766}},
  language     = {{eng}},
  month        = {{04}},
  pages        = {{312--312}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Reviews Neurology}},
  title        = {{Parkinson disease and growth factors — is GDNF good enough?}},
  url          = {{http://dx.doi.org/10.1038/s41582-019-0180-6}},
  doi          = {{10.1038/s41582-019-0180-6}},
  volume       = {{15}},
  year         = {{2019}},
}