Periodontal conditions, retinopathy, and serum markers in individuals with type 1 diabetes
Widén, Cecilia ; Holmer, Helene LU ; Sättlin, Susanna ; Renvert, Stefan ; Lernmark, Åke LU
and Persson, G Rutger
(2020)
In Journal of Periodontology
91(11).
p.1436-1443
- Abstract
BACKGROUND: The prevalence of diabetes is high and increasing. Periodontitis has been identified as a risk factor in both type 1 and 2 diabetes. The study purpose was to assess periodontal conditions, retinopathy, and serum glutamic acid decarboxylase antibody (GADA) titers in relation to retinopathy in individuals with Type 1 Diabetes (T1D).
METHODS: The study is a case series. Adult individuals with a diagnosis of T1D (n = 85) monitored ≥five years were recruited from an endocrinology clinic. Peripheral venous blood samples were analyzed including assessments of serum HbA1c levels and GADA titers. Medical and periodontal conditions were examined, and the data assessed. Independent t-tests, binary and multivariate analyses, chi... (More)
BACKGROUND: The prevalence of diabetes is high and increasing. Periodontitis has been identified as a risk factor in both type 1 and 2 diabetes. The study purpose was to assess periodontal conditions, retinopathy, and serum glutamic acid decarboxylase antibody (GADA) titers in relation to retinopathy in individuals with Type 1 Diabetes (T1D).
METHODS: The study is a case series. Adult individuals with a diagnosis of T1D (n = 85) monitored ≥five years were recruited from an endocrinology clinic. Peripheral venous blood samples were analyzed including assessments of serum HbA1c levels and GADA titers. Medical and periodontal conditions were examined, and the data assessed. Independent t-tests, binary and multivariate analyses, chi square and odds ratios were employed.
RESULTS: Gingivitis was found in 68.2%, periodontitis in 21.2%, and retinopathy in 64.7%, GADA (≥35 U/ml) in 54.1%, and serum HbA1c > 48 mmol/mol in 94.3% of the individuals. The unadjusted odds ratio for periodontitis to differentiate a diagnosis of retinopathy was 7.3 (95%CI 1.6, 4.4, p <0.01). Multivariate analyses identified the following dependent factors to differentiate retinopathy; age, T1D duration, gingivitis, periodontitis at p < 0.001, gender, and serum GADA at P < 0.01, and by the number of remaining teeth at P < 0.05.
CONCLUSION: Retinopathy as a complication to T1D is linked to the duration of diabetes, age of the individual and with increasing severity to periodontitis. Periodontal intervention studies are warranted. This article is protected by copyright. All rights reserved.
(Less)
- author
- Widén, Cecilia
; Holmer, Helene
LU
; Sättlin, Susanna
; Renvert, Stefan
; Lernmark, Åke
LU
and Persson, G Rutger
- organization
- publishing date
- 2020-11
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Periodontology
- volume
- 91
- issue
- 11
- pages
- 8 pages
- publisher
- American Academy of Periodontology
- external identifiers
-
- scopus:85087312531
- pmid:32484239
- ISSN
- 0022-3492
- DOI
- 10.1002/JPER.19-0641
- language
- English
- LU publication?
- yes
- additional info
- This article is protected by copyright. All rights reserved.
- id
- 09e5587e-2e75-45e6-a0fb-6fbc45228df1
- date added to LUP
- 2020-06-05 23:21:26
- date last changed
- 2024-06-26 17:15:33
@article{09e5587e-2e75-45e6-a0fb-6fbc45228df1,
abstract = {{<p>BACKGROUND: The prevalence of diabetes is high and increasing. Periodontitis has been identified as a risk factor in both type 1 and 2 diabetes. The study purpose was to assess periodontal conditions, retinopathy, and serum glutamic acid decarboxylase antibody (GADA) titers in relation to retinopathy in individuals with Type 1 Diabetes (T1D).</p><p>METHODS: The study is a case series. Adult individuals with a diagnosis of T1D (n = 85) monitored ≥five years were recruited from an endocrinology clinic. Peripheral venous blood samples were analyzed including assessments of serum HbA1c levels and GADA titers. Medical and periodontal conditions were examined, and the data assessed. Independent t-tests, binary and multivariate analyses, chi square and odds ratios were employed.</p><p>RESULTS: Gingivitis was found in 68.2%, periodontitis in 21.2%, and retinopathy in 64.7%, GADA (≥35 U/ml) in 54.1%, and serum HbA1c > 48 mmol/mol in 94.3% of the individuals. The unadjusted odds ratio for periodontitis to differentiate a diagnosis of retinopathy was 7.3 (95%CI 1.6, 4.4, p <0.01). Multivariate analyses identified the following dependent factors to differentiate retinopathy; age, T1D duration, gingivitis, periodontitis at p < 0.001, gender, and serum GADA at P < 0.01, and by the number of remaining teeth at P < 0.05.</p><p>CONCLUSION: Retinopathy as a complication to T1D is linked to the duration of diabetes, age of the individual and with increasing severity to periodontitis. Periodontal intervention studies are warranted. This article is protected by copyright. All rights reserved.</p>}},
author = {{Widén, Cecilia and Holmer, Helene and Sättlin, Susanna and Renvert, Stefan and Lernmark, Åke and Persson, G Rutger}},
issn = {{0022-3492}},
language = {{eng}},
number = {{11}},
pages = {{1436--1443}},
publisher = {{American Academy of Periodontology}},
series = {{Journal of Periodontology}},
title = {{Periodontal conditions, retinopathy, and serum markers in individuals with type 1 diabetes}},
url = {{http://dx.doi.org/10.1002/JPER.19-0641}},
doi = {{10.1002/JPER.19-0641}},
volume = {{91}},
year = {{2020}},
}