The Kärger vs bi-exponential model : Theoretical insights and experimental validations
(2018) In Journal of Magnetic Resonance 296. p.72-78- Abstract
We revise three common models accounting for water exchange in pulsed-gradient spin-echo measurements: a bi-exponential model with time-dependent water fractions, the Kärger model, and a modified Kärger model designed for restricted diffusion, e.g. inside cells. The three models are compared and applied to experimental data from yeast cell suspensions. The Kärger model and the modified Kärger model yield very close results and accurately fit the data. The bi-exponential model, although less rigorous, has a natural physical interpretation and suggests a new experimental modality to estimate the water exchange time.
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https://lup.lub.lu.se/record/0e5d952c-08dd-4018-8ff1-255213658e92
- author
- Moutal, Nicolas ; Nilsson, Markus LU ; Topgaard, Daniel LU and Grebenkov, Denis
- organization
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Bi-exponential model, Kärger model, Permeability, PGSE, Water exchange, Yeast cells
- in
- Journal of Magnetic Resonance
- volume
- 296
- pages
- 7 pages
- publisher
- Academic Press
- external identifiers
-
- pmid:30223153
- scopus:85053311723
- ISSN
- 1090-7807
- DOI
- 10.1016/j.jmr.2018.08.015
- language
- English
- LU publication?
- yes
- id
- 0e5d952c-08dd-4018-8ff1-255213658e92
- date added to LUP
- 2018-10-09 08:28:28
- date last changed
- 2024-07-08 20:35:01
@article{0e5d952c-08dd-4018-8ff1-255213658e92, abstract = {{<p>We revise three common models accounting for water exchange in pulsed-gradient spin-echo measurements: a bi-exponential model with time-dependent water fractions, the Kärger model, and a modified Kärger model designed for restricted diffusion, e.g. inside cells. The three models are compared and applied to experimental data from yeast cell suspensions. The Kärger model and the modified Kärger model yield very close results and accurately fit the data. The bi-exponential model, although less rigorous, has a natural physical interpretation and suggests a new experimental modality to estimate the water exchange time.</p>}}, author = {{Moutal, Nicolas and Nilsson, Markus and Topgaard, Daniel and Grebenkov, Denis}}, issn = {{1090-7807}}, keywords = {{Bi-exponential model; Kärger model; Permeability; PGSE; Water exchange; Yeast cells}}, language = {{eng}}, pages = {{72--78}}, publisher = {{Academic Press}}, series = {{Journal of Magnetic Resonance}}, title = {{The Kärger vs bi-exponential model : Theoretical insights and experimental validations}}, url = {{http://dx.doi.org/10.1016/j.jmr.2018.08.015}}, doi = {{10.1016/j.jmr.2018.08.015}}, volume = {{296}}, year = {{2018}}, }