ADAMTS-7 is associated with a high-risk plaque phenotype in human atherosclerosis
(2017) In Scientific Reports 7(1).- Abstract
Several large-scale genome-wide association studies have identified single-nucleotide polymorphisms in the genomic region of A Disintegrin And Metalloproteinase with ThromboSpondin type 1 repeats (ADAMTS)-7 and associations to coronary artery disease. Experimental studies have provided evidence for a functional role of ADAMTS-7 in both injury-induced vascular neointima formation and development of atherosclerotic lesions. However, whether ADAMTS-7 is associated with a specific plaque phenotype in humans has not been investigated. Carotid plaques (n = 206) from patients with and without cerebrovascular symptoms were analyzed for expression of ADAMTS-7 by immunohistochemistry and correlated to components associated with plaque... (More)
Several large-scale genome-wide association studies have identified single-nucleotide polymorphisms in the genomic region of A Disintegrin And Metalloproteinase with ThromboSpondin type 1 repeats (ADAMTS)-7 and associations to coronary artery disease. Experimental studies have provided evidence for a functional role of ADAMTS-7 in both injury-induced vascular neointima formation and development of atherosclerotic lesions. However, whether ADAMTS-7 is associated with a specific plaque phenotype in humans has not been investigated. Carotid plaques (n = 206) from patients with and without cerebrovascular symptoms were analyzed for expression of ADAMTS-7 by immunohistochemistry and correlated to components associated with plaque vulnerability. Plaques from symptomatic patients showed increased levels of ADAMTS-7 compared with lesions from asymptomatic patients. High levels of ADAMTS-7 correlated with high levels of CD68-staining and lipid content, but with low smooth muscle cell and collagen content, which together are characteristics of a vulnerable plaque phenotype. ADAMTS-7 levels above median were associated with increased risk for postoperative cardiovascular events. Our data show that ADAMTS-7 is associated with a vulnerable plaque phenotype in human carotid lesions. These data support previous observations of a potential proatherogenic role of ADAMTS-7.
(Less)
- author
- Bengtsson, Eva
LU
; Hultman, Karin LU ; Dunér, Pontus LU ; Asciutto, Giuseppe LU ; Almgren, Peter LU ; Orho-Melander, Marju LU ; Melander, Olle LU
; Nilsson, Jan LU ; Hultgårdh, Anna LU and Gonçalves, Isabel LU
- organization
-
- EXODIAB: Excellence of Diabetes Research in Sweden
- EpiHealth: Epidemiology for Health
- Cardiovascular Research - Immunity and Atherosclerosis (research group)
- Translational Muscle Research (research group)
- Diabetes - Cardiovascular Disease (research group)
- Cardiovascular Research - Hypertension (research group)
- Vessel Wall Biology (research group)
- Cardiovascular Research - Translational Studies (research group)
- publishing date
- 2017-12-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scientific Reports
- volume
- 7
- issue
- 1
- article number
- 3753
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:28623250
- wos:000403413700115
- scopus:85020913587
- ISSN
- 2045-2322
- DOI
- 10.1038/s41598-017-03573-4
- language
- English
- LU publication?
- yes
- id
- 0ed76b9d-284c-4034-a33b-583a4c001183
- date added to LUP
- 2017-07-03 14:35:16
- date last changed
- 2024-09-02 03:07:21
@article{0ed76b9d-284c-4034-a33b-583a4c001183, abstract = {{<p>Several large-scale genome-wide association studies have identified single-nucleotide polymorphisms in the genomic region of A Disintegrin And Metalloproteinase with ThromboSpondin type 1 repeats (ADAMTS)-7 and associations to coronary artery disease. Experimental studies have provided evidence for a functional role of ADAMTS-7 in both injury-induced vascular neointima formation and development of atherosclerotic lesions. However, whether ADAMTS-7 is associated with a specific plaque phenotype in humans has not been investigated. Carotid plaques (n = 206) from patients with and without cerebrovascular symptoms were analyzed for expression of ADAMTS-7 by immunohistochemistry and correlated to components associated with plaque vulnerability. Plaques from symptomatic patients showed increased levels of ADAMTS-7 compared with lesions from asymptomatic patients. High levels of ADAMTS-7 correlated with high levels of CD68-staining and lipid content, but with low smooth muscle cell and collagen content, which together are characteristics of a vulnerable plaque phenotype. ADAMTS-7 levels above median were associated with increased risk for postoperative cardiovascular events. Our data show that ADAMTS-7 is associated with a vulnerable plaque phenotype in human carotid lesions. These data support previous observations of a potential proatherogenic role of ADAMTS-7.</p>}}, author = {{Bengtsson, Eva and Hultman, Karin and Dunér, Pontus and Asciutto, Giuseppe and Almgren, Peter and Orho-Melander, Marju and Melander, Olle and Nilsson, Jan and Hultgårdh, Anna and Gonçalves, Isabel}}, issn = {{2045-2322}}, language = {{eng}}, month = {{12}}, number = {{1}}, publisher = {{Nature Publishing Group}}, series = {{Scientific Reports}}, title = {{ADAMTS-7 is associated with a high-risk plaque phenotype in human atherosclerosis}}, url = {{http://dx.doi.org/10.1038/s41598-017-03573-4}}, doi = {{10.1038/s41598-017-03573-4}}, volume = {{7}}, year = {{2017}}, }