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Choreography of the centrosome

Alvarado Kristensson, Maria LU (2020) In Heliyon 6(e03228). p.1-6
Abstract
More than a century ago, the centrosome was discovered and described as “the true division organ of the cell”. Electron microscopy revealed that a centrosome is an amorphous structure or pericentriolar protein matrix that surrounds a pair of well-organized centrioles. Today, the importance of the centrosome as a microtubule-organizing center and coordinator of the mitotic spindle is questioned, because centrioles are absent in up to half of all known eukaryotic species, and various mechanisms for acentrosomal microtubule nucleation have been described. This review recapitulates the known functions of centrosome movements in cellular homeostasis and discusses knowledge gaps in this field.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Heliyon
volume
6
issue
e03228
article number
e03238
pages
1 - 6
publisher
Elsevier
external identifiers
  • scopus:85077989306
  • pmid:31989056
ISSN
2405-8440
DOI
10.1016/j.heliyon.2020.e03238
language
English
LU publication?
yes
id
1031e15c-8b98-46fb-a108-b29536c7fb5c
date added to LUP
2020-01-18 10:13:10
date last changed
2022-05-04 03:34:30
@article{1031e15c-8b98-46fb-a108-b29536c7fb5c,
  abstract     = {{More than a century ago, the centrosome was discovered and described as “the true division organ of the cell”. Electron microscopy revealed that a centrosome is an amorphous structure or pericentriolar protein matrix that surrounds a pair of well-organized centrioles. Today, the importance of the centrosome as a microtubule-organizing center and coordinator of the mitotic spindle is questioned, because centrioles are absent in up to half of all known eukaryotic species, and various mechanisms for acentrosomal microtubule nucleation have been described. This review recapitulates the known functions of centrosome movements in cellular homeostasis and discusses knowledge gaps in this field.}},
  author       = {{Alvarado Kristensson, Maria}},
  issn         = {{2405-8440}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{e03228}},
  pages        = {{1--6}},
  publisher    = {{Elsevier}},
  series       = {{Heliyon}},
  title        = {{Choreography of the centrosome}},
  url          = {{http://dx.doi.org/10.1016/j.heliyon.2020.e03238}},
  doi          = {{10.1016/j.heliyon.2020.e03238}},
  volume       = {{6}},
  year         = {{2020}},
}