Atrial myocardial pathoelectrophysiology in adults with a secundum atrial septal defect is unaffected by closure of the defect. A study using high resolution signal-averaged orthogonal P-wave technique.

Thilén, Ulf; Carlson, Jonas; Platonov, Pyotr; Olsson, Bertil

Atrial myocardial pathoelectrophysiology in adults with a secundum atrial septal defect is unaffected by closure of the defect. A study using high resolution signal-averaged orthogonal P-wave technique.

Mark

Thilén, Ulf ^LU ; Carlson, Jonas ^LU

; Platonov, Pyotr ^LU and Olsson, Bertil ^LU (2009) In International Journal of Cardiology 132. p.364-368

Abstract: BACKGROUND: In patients with atrial septal defect (ASD) the P-wave is prolonged as a marker of delayed atrial conduction which is associated with atrial fibrillation. The study aim was to analyse the impact of ASD closure in adults on P-wave duration and morphology by means of signal-averaged P-waves (PSA-ECG) and to investigate potential mechano-electrical interactions. METHODS: PSA-ECG was obtained before and 8+/-6 months after ASD closure in 35 adult patients (age 53+/-15 years). Heart chamber sizes and pulmonary artery pressure levels were assessed by echoDopplercardiography. RESULTS: P-wave duration and morphology did not change after ASD closure (148+/-16 vs 144+/-16 ms, P=0.07). P-wave duration did not relate to age at repair,... (More); BACKGROUND: In patients with atrial septal defect (ASD) the P-wave is prolonged as a marker of delayed atrial conduction which is associated with atrial fibrillation. The study aim was to analyse the impact of ASD closure in adults on P-wave duration and morphology by means of signal-averaged P-waves (PSA-ECG) and to investigate potential mechano-electrical interactions. METHODS: PSA-ECG was obtained before and 8+/-6 months after ASD closure in 35 adult patients (age 53+/-15 years). Heart chamber sizes and pulmonary artery pressure levels were assessed by echoDopplercardiography. RESULTS: P-wave duration and morphology did not change after ASD closure (148+/-16 vs 144+/-16 ms, P=0.07). P-wave duration did not relate to age at repair, preclosure atrial sizes or pulmonary artery pressure. Pre- or postclosure atrial fibrillation propensity was associated with longer P-wave duration both before and after ASD closure. CONCLUSION: Atrial conduction disturbances in middle-aged patients with ASD, manifested as a prolonged P-wave duration, do not change after ASD closure and are not related to the dilatation of the right and left atria. It is suggestive that atrial conduction disturbance associated with ASD develop early and early intervention is required to prevent the development of late atrial fibrillation. (Less)

Please use this url to cite or link to this publication: https://lup.lub.lu.se/record/1042324

author

Thilén, Ulf ^LU ; Carlson, Jonas ^LU

; Platonov, Pyotr ^LU and Olsson, Bertil ^LU

organization

Cardiology

publishing date

2009

type

Contribution to journal

publication status

published

subject

Cardiac and Cardiovascular Systems

keywords

P-wave duration, Signal-averaged P-wave ECG, Atrial septal defect, Atrial fibrillation, Electric remodelling, Closure of atrial septal defect

in

International Journal of Cardiology

volume

132

pages

5 pages

publisher

Elsevier

external identifiers

pmid:18242736
wos:000263892200010
scopus:60649102050
pmid:18242736

ISSN

0167-5273

DOI

10.1016/j.ijcard.2007.11.101

language

English

LU publication?

yes

id

3e9b2259-a5a8-4cd9-9a92-08887684ab0e (old id 1042324)

date added to LUP

2016-04-01 11:57:04

date last changed

2022-03-28 18:01:19

@article{3e9b2259-a5a8-4cd9-9a92-08887684ab0e,
  abstract     = {{BACKGROUND: In patients with atrial septal defect (ASD) the P-wave is prolonged as a marker of delayed atrial conduction which is associated with atrial fibrillation. The study aim was to analyse the impact of ASD closure in adults on P-wave duration and morphology by means of signal-averaged P-waves (PSA-ECG) and to investigate potential mechano-electrical interactions. METHODS: PSA-ECG was obtained before and 8+/-6 months after ASD closure in 35 adult patients (age 53+/-15 years). Heart chamber sizes and pulmonary artery pressure levels were assessed by echoDopplercardiography. RESULTS: P-wave duration and morphology did not change after ASD closure (148+/-16 vs 144+/-16 ms, P=0.07). P-wave duration did not relate to age at repair, preclosure atrial sizes or pulmonary artery pressure. Pre- or postclosure atrial fibrillation propensity was associated with longer P-wave duration both before and after ASD closure. CONCLUSION: Atrial conduction disturbances in middle-aged patients with ASD, manifested as a prolonged P-wave duration, do not change after ASD closure and are not related to the dilatation of the right and left atria. It is suggestive that atrial conduction disturbance associated with ASD develop early and early intervention is required to prevent the development of late atrial fibrillation.}},
  author       = {{Thilén, Ulf and Carlson, Jonas and Platonov, Pyotr and Olsson, Bertil}},
  issn         = {{0167-5273}},
  keywords     = {{P-wave duration; Signal-averaged P-wave ECG; Atrial septal defect; Atrial fibrillation; Electric remodelling; Closure of atrial septal defect}},
  language     = {{eng}},
  pages        = {{364--368}},
  publisher    = {{Elsevier}},
  series       = {{International Journal of Cardiology}},
  title        = {{Atrial myocardial pathoelectrophysiology in adults with a secundum atrial septal defect is unaffected by closure of the defect. A study using high resolution signal-averaged orthogonal P-wave technique.}},
  url          = {{http://dx.doi.org/10.1016/j.ijcard.2007.11.101}},
  doi          = {{10.1016/j.ijcard.2007.11.101}},
  volume       = {{132}},
  year         = {{2009}},
}

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Atrial myocardial pathoelectrophysiology in adults with a secundum atrial septal defect is unaffected by closure of the defect. A study using high resolution signal-averaged orthogonal P-wave technique.