Gender difference in the glucagon response to glucopenic stress in mice.
(2002) In American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 282(1). p.281-288- Abstract
- A gender difference in the glucagon response to insulin-induced hypoglycemia was previously demonstrated in humans. Whether this reflects a gender difference in autonomic activation or in pancreatic alpha-cell regulation is not known. We investigated the glucagon, epinephrine, and norepinephrine responses to neuroglycopenic stress induced by 2-deoxy-D-glucose (2-DG) or insulin in female and male mice. 2-DG increased plasma glucagon levels by 559 +/- 68% in females versus 281 +/- 46% in males (P < 0.01). Plasma levels of epinephrine or norepinephrine after 2-DG administration did not differ between genders. During insulin-induced hypoglycemia, the glucagon response was similarly higher in females (P < 0.001), whereas the plasma... (More)
- A gender difference in the glucagon response to insulin-induced hypoglycemia was previously demonstrated in humans. Whether this reflects a gender difference in autonomic activation or in pancreatic alpha-cell regulation is not known. We investigated the glucagon, epinephrine, and norepinephrine responses to neuroglycopenic stress induced by 2-deoxy-D-glucose (2-DG) or insulin in female and male mice. 2-DG increased plasma glucagon levels by 559 +/- 68% in females versus 281 +/- 46% in males (P < 0.01). Plasma levels of epinephrine or norepinephrine after 2-DG administration did not differ between genders. During insulin-induced hypoglycemia, the glucagon response was similarly higher in females (P < 0.001), whereas the plasma catecholamine response was higher in males (P < 0.05). In vivo, the glucagon response to carbachol or clonidine was higher in females (P < 0.05). In isolated islets, the glucagon response to carbachol (100 microM; P = 0.003) but not to clonidine (1 microM) was larger in females. We conclude that in addition to a larger alpha-cell mass (previously described in female mice), an increased sensitivity of the glucagon-producing alpha-cell to cholinergic activation contributes to the larger glucagon response to glucopenic stress in female mice. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/107024
- author
- Karlsson, Sven ; Scheurink, Anton J W and Ahrén, Bo LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Sympatholytics : pharmacology, Stress : metabolism, Sex Characteristics, Norepinephrine : blood, Mice Inbred Strains, Mice, Male, Islets of Langerhans : drug effects : physiology : secretion, Insulin : pharmacology, Hypoglycemic Agents : pharmacology, Female, Glucagon : blood : secretion, Hypoglycemia : chemically induced : metabolism, Epinephrine : blood, Clonidine : pharmacology, Deoxyglucose : pharmacology, Support Non-U.S. Gov't, Cholinergic Agonists : pharmacology, Carbachol : pharmacology, Blood Glucose : metabolism, Autonomic Nervous System : metabolism, Antimetabolites : pharmacology, Animal, Adrenal Glands : physiology
- in
- American Journal of Physiology: Regulatory, Integrative and Comparative Physiology
- volume
- 282
- issue
- 1
- pages
- 281 - 288
- publisher
- American Physiological Society
- external identifiers
-
- wos:000172722000034
- pmid:11742849
- scopus:0036083645
- ISSN
- 0363-6119
- language
- English
- LU publication?
- yes
- id
- 437ec404-89c8-4b0e-b1ca-cd4b1d535554 (old id 107024)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11742849&dopt=Abstract
- http://ajpregu.physiology.org/cgi/content/full/282/1/R281
- date added to LUP
- 2016-04-01 17:05:35
- date last changed
- 2024-01-11 19:26:55
@article{437ec404-89c8-4b0e-b1ca-cd4b1d535554,
abstract = {{A gender difference in the glucagon response to insulin-induced hypoglycemia was previously demonstrated in humans. Whether this reflects a gender difference in autonomic activation or in pancreatic alpha-cell regulation is not known. We investigated the glucagon, epinephrine, and norepinephrine responses to neuroglycopenic stress induced by 2-deoxy-D-glucose (2-DG) or insulin in female and male mice. 2-DG increased plasma glucagon levels by 559 +/- 68% in females versus 281 +/- 46% in males (P < 0.01). Plasma levels of epinephrine or norepinephrine after 2-DG administration did not differ between genders. During insulin-induced hypoglycemia, the glucagon response was similarly higher in females (P < 0.001), whereas the plasma catecholamine response was higher in males (P < 0.05). In vivo, the glucagon response to carbachol or clonidine was higher in females (P < 0.05). In isolated islets, the glucagon response to carbachol (100 microM; P = 0.003) but not to clonidine (1 microM) was larger in females. We conclude that in addition to a larger alpha-cell mass (previously described in female mice), an increased sensitivity of the glucagon-producing alpha-cell to cholinergic activation contributes to the larger glucagon response to glucopenic stress in female mice.}},
author = {{Karlsson, Sven and Scheurink, Anton J W and Ahrén, Bo}},
issn = {{0363-6119}},
keywords = {{Sympatholytics : pharmacology; Stress : metabolism; Sex Characteristics; Norepinephrine : blood; Mice Inbred Strains; Mice; Male; Islets of Langerhans : drug effects : physiology : secretion; Insulin : pharmacology; Hypoglycemic Agents : pharmacology; Female; Glucagon : blood : secretion; Hypoglycemia : chemically induced : metabolism; Epinephrine : blood; Clonidine : pharmacology; Deoxyglucose : pharmacology; Support Non-U.S. Gov't; Cholinergic Agonists : pharmacology; Carbachol : pharmacology; Blood Glucose : metabolism; Autonomic Nervous System : metabolism; Antimetabolites : pharmacology; Animal; Adrenal Glands : physiology}},
language = {{eng}},
number = {{1}},
pages = {{281--288}},
publisher = {{American Physiological Society}},
series = {{American Journal of Physiology: Regulatory, Integrative and Comparative Physiology}},
title = {{Gender difference in the glucagon response to glucopenic stress in mice.}},
url = {{http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11742849&dopt=Abstract}},
volume = {{282}},
year = {{2002}},
}