Platelet and leukocyte activation during aortoiliac angiography and angioplasty.
(2002) In European Journal of Vascular and Endovascular Surgery 23(3). p.220-225- Abstract
- OBJECTIVE: to evaluate platelet and leukocyte activation during aortoiliac angiography and percutaneous transluminal angioplasty (PTA). METHODS: an observational study of 14 patients with aortoiliac atherosclerotic disease, nine of whom underwent PTA. The proportion of fibrinogen-, and P-selectin positive platelets, P-selectin expression on platelets, intraplatelet cGMP and cAMP, CD18 positive granulocytes, CD18 expression on granulocytes, plasma (p)-neopterin, p-TNF alpha and p- interleukin-6 were repeatedly measured in arterial blood during angiography and in venous blood before and after. RESULTS: compared to a previous venous sample, arterial intraplatelet cAMP was increased proximal to the atherosclerotic lesion before contrast... (More)
- OBJECTIVE: to evaluate platelet and leukocyte activation during aortoiliac angiography and percutaneous transluminal angioplasty (PTA). METHODS: an observational study of 14 patients with aortoiliac atherosclerotic disease, nine of whom underwent PTA. The proportion of fibrinogen-, and P-selectin positive platelets, P-selectin expression on platelets, intraplatelet cGMP and cAMP, CD18 positive granulocytes, CD18 expression on granulocytes, plasma (p)-neopterin, p-TNF alpha and p- interleukin-6 were repeatedly measured in arterial blood during angiography and in venous blood before and after. RESULTS: compared to a previous venous sample, arterial intraplatelet cAMP was increased proximal to the atherosclerotic lesion before contrast infusion and PTA (median 18 [range: 14-22] vs 16 [15-21] pmol/10(9) platelets p<0.05), and intraplatelet cGMP was increased proximal to the lesion after contrast infusion and PTA (1.2 [0.8-3.9] vs 0.9 [0.6-2.5] pmol/10(9) platelets p<0.05). Four hours after angiography, both the proportion of P-selectin positive platelets (28[11-55]%) and platelet P-selectin expression (9[6-40]) had decreased (p<0.05), from arterial values distal to the lesion before contrast infusion and PTA (57 [24-78]% and 26 [10-83]). Granulocyte CD18 expression was lower during angiography than in a previous venous sample. CONCLUSIONS: the results are compatible with platelet but not leukocyte activation during peripheral angiography. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/107179
- author
- Barani, Jamal LU ; Gottsäter, Anders LU ; Mattiasson, Ingrid LU and Lindblad, Bengt LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Iliac Artery : physiopathology, Iliac Artery : radiography, Female, Contrast Media : pharmacology, Arteriosclerosis : therapy, Arteriosclerosis : physiopathology, Aortography, Aorta : physiopathology, Aorta : drug effects, Balloon, Angiography, Angioplasty, 80 and over, Aged, Leukocytes : drug effects, Male, Leukocytes : physiology, Iliac Artery : drug effects, Human, Middle Age, Platelet Activation : drug effects, Platelet Activation : physiology
- in
- European Journal of Vascular and Endovascular Surgery
- volume
- 23
- issue
- 3
- pages
- 220 - 225
- publisher
- Elsevier
- external identifiers
-
- pmid:11914008
- wos:000175095600006
- scopus:0036515072
- ISSN
- 1532-2165
- DOI
- 10.1053/ejvs.2001.1594
- language
- English
- LU publication?
- yes
- id
- 63fc3fa3-8dc1-4e21-aeaf-d6e247bc2756 (old id 107179)
- alternative location
- http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11914008&dopt=Abstract
- date added to LUP
- 2016-04-01 16:00:20
- date last changed
- 2022-01-28 08:38:52
@article{63fc3fa3-8dc1-4e21-aeaf-d6e247bc2756,
abstract = {{OBJECTIVE: to evaluate platelet and leukocyte activation during aortoiliac angiography and percutaneous transluminal angioplasty (PTA). METHODS: an observational study of 14 patients with aortoiliac atherosclerotic disease, nine of whom underwent PTA. The proportion of fibrinogen-, and P-selectin positive platelets, P-selectin expression on platelets, intraplatelet cGMP and cAMP, CD18 positive granulocytes, CD18 expression on granulocytes, plasma (p)-neopterin, p-TNF alpha and p- interleukin-6 were repeatedly measured in arterial blood during angiography and in venous blood before and after. RESULTS: compared to a previous venous sample, arterial intraplatelet cAMP was increased proximal to the atherosclerotic lesion before contrast infusion and PTA (median 18 [range: 14-22] vs 16 [15-21] pmol/10(9) platelets p<0.05), and intraplatelet cGMP was increased proximal to the lesion after contrast infusion and PTA (1.2 [0.8-3.9] vs 0.9 [0.6-2.5] pmol/10(9) platelets p<0.05). Four hours after angiography, both the proportion of P-selectin positive platelets (28[11-55]%) and platelet P-selectin expression (9[6-40]) had decreased (p<0.05), from arterial values distal to the lesion before contrast infusion and PTA (57 [24-78]% and 26 [10-83]). Granulocyte CD18 expression was lower during angiography than in a previous venous sample. CONCLUSIONS: the results are compatible with platelet but not leukocyte activation during peripheral angiography.}},
author = {{Barani, Jamal and Gottsäter, Anders and Mattiasson, Ingrid and Lindblad, Bengt}},
issn = {{1532-2165}},
keywords = {{Iliac Artery : physiopathology; Iliac Artery : radiography; Female; Contrast Media : pharmacology; Arteriosclerosis : therapy; Arteriosclerosis : physiopathology; Aortography; Aorta : physiopathology; Aorta : drug effects; Balloon; Angiography; Angioplasty; 80 and over; Aged; Leukocytes : drug effects; Male; Leukocytes : physiology; Iliac Artery : drug effects; Human; Middle Age; Platelet Activation : drug effects; Platelet Activation : physiology}},
language = {{eng}},
number = {{3}},
pages = {{220--225}},
publisher = {{Elsevier}},
series = {{European Journal of Vascular and Endovascular Surgery}},
title = {{Platelet and leukocyte activation during aortoiliac angiography and angioplasty.}},
url = {{http://dx.doi.org/10.1053/ejvs.2001.1594}},
doi = {{10.1053/ejvs.2001.1594}},
volume = {{23}},
year = {{2002}},
}