The molecular pathogenesis of collagen-induced arthritis in mice--a model for rheumatoid arthritis.
(2002) In Ageing Research Reviews 1(1). p.135-147- Abstract
- The most widely used model for rheumatoid arthritis is the collagen-induced arthritis (CIA) in mice. This model has gained acceptance since it is reproducible, well defined and has proven useful for development of new therapies for rheumatoid arthritis, as exemplified by the most recent advancement using TNFalpha neutralization treatment. The collagen-induced arthritis model, however, represents only certain pathways leading to arthritis and there is no consensus on how they operate. Nevertheless, we are beginning to understand the immune recognition structures, such as MHC molecules, lymphocyte receptors and type II collagen epitopes, which are of crucial importance for the development of this disease. These provide useful tools for... (More)
- The most widely used model for rheumatoid arthritis is the collagen-induced arthritis (CIA) in mice. This model has gained acceptance since it is reproducible, well defined and has proven useful for development of new therapies for rheumatoid arthritis, as exemplified by the most recent advancement using TNFalpha neutralization treatment. The collagen-induced arthritis model, however, represents only certain pathways leading to arthritis and there is no consensus on how they operate. Nevertheless, we are beginning to understand the immune recognition structures, such as MHC molecules, lymphocyte receptors and type II collagen epitopes, which are of crucial importance for the development of this disease. These provide useful tools for further investigations of the pathogenesis of CIA as well as for understanding the pathogenesis of rheumatoid arthritis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/108625
- author
- Holmdahl, Rikard LU ; Bockermann, Robert LU ; Bäcklund, Johan LU and Yamada, Hisakata LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Genes, MHC Class II : genetics, Animal, Disease Models, Collagen, Rheumatoid : physiopathology, Arthritis, Rheumatoid : genetics, Rheumatoid : chemically induced, Arthritis : physiopathology, Arthritis : genetics, Arthritis : chemically induced, MHC Class II : physiology, Human, Mice, Support, Non-U.S. Gov't, T-Lymphocytes : physiology
- in
- Ageing Research Reviews
- volume
- 1
- issue
- 1
- pages
- 135 - 147
- publisher
- Elsevier
- external identifiers
-
- wos:000178536700010
- pmid:12039453
- scopus:0036484325
- ISSN
- 1872-9649
- DOI
- 10.1016/S0047-6374(01)00371-2
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Inflammation Research (013212019)
- id
- cdb041c7-f1d6-42f3-af06-e906e74c1aa2 (old id 108625)
- alternative location
- http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12039453&dopt=Abstract
- date added to LUP
- 2016-04-01 12:18:14
- date last changed
- 2022-02-11 05:09:43
@article{cdb041c7-f1d6-42f3-af06-e906e74c1aa2, abstract = {{The most widely used model for rheumatoid arthritis is the collagen-induced arthritis (CIA) in mice. This model has gained acceptance since it is reproducible, well defined and has proven useful for development of new therapies for rheumatoid arthritis, as exemplified by the most recent advancement using TNFalpha neutralization treatment. The collagen-induced arthritis model, however, represents only certain pathways leading to arthritis and there is no consensus on how they operate. Nevertheless, we are beginning to understand the immune recognition structures, such as MHC molecules, lymphocyte receptors and type II collagen epitopes, which are of crucial importance for the development of this disease. These provide useful tools for further investigations of the pathogenesis of CIA as well as for understanding the pathogenesis of rheumatoid arthritis.}}, author = {{Holmdahl, Rikard and Bockermann, Robert and Bäcklund, Johan and Yamada, Hisakata}}, issn = {{1872-9649}}, keywords = {{Genes; MHC Class II : genetics; Animal; Disease Models; Collagen; Rheumatoid : physiopathology; Arthritis; Rheumatoid : genetics; Rheumatoid : chemically induced; Arthritis : physiopathology; Arthritis : genetics; Arthritis : chemically induced; MHC Class II : physiology; Human; Mice; Support; Non-U.S. Gov't; T-Lymphocytes : physiology}}, language = {{eng}}, number = {{1}}, pages = {{135--147}}, publisher = {{Elsevier}}, series = {{Ageing Research Reviews}}, title = {{The molecular pathogenesis of collagen-induced arthritis in mice--a model for rheumatoid arthritis.}}, url = {{http://dx.doi.org/10.1016/S0047-6374(01)00371-2}}, doi = {{10.1016/S0047-6374(01)00371-2}}, volume = {{1}}, year = {{2002}}, }