Epilepsy in immigrants and Swedish-born : A cohort study of all adults 18 years of age and older in Sweden
(2020) In Seizure 76. p.116-122- Abstract
Purpose: We aimed to study the association between country of birth and incident epilepsy in several immigrant groups using Swedish-born individuals as referents. Method: The study population included all adults aged 18 years and older in Sweden, living and deceased, 6,690,598 in the first-generation and 6,683,125 in the second-generation sub-study. Epilepsy was defined as having at least one registered diagnosis of epilepsy in the National Patient Register. The incidence of epilepsy in different immigrant groups, using Swedish-born as referents, was assessed by Cox regression, expressed as hazard ratios (HRs) and 95 % confidence intervals (CI). The models were stratified by sex and adjusted for age, geographical residence in Sweden,... (More)
Purpose: We aimed to study the association between country of birth and incident epilepsy in several immigrant groups using Swedish-born individuals as referents. Method: The study population included all adults aged 18 years and older in Sweden, living and deceased, 6,690,598 in the first-generation and 6,683,125 in the second-generation sub-study. Epilepsy was defined as having at least one registered diagnosis of epilepsy in the National Patient Register. The incidence of epilepsy in different immigrant groups, using Swedish-born as referents, was assessed by Cox regression, expressed as hazard ratios (HRs) and 95 % confidence intervals (CI). The models were stratified by sex and adjusted for age, geographical residence in Sweden, educational level, marital status, and neighbourhood socioeconomic status. Results: In the first-generation sub-study, totally 76,541 individuals had at least one registered diagnosis of epilepsy (1.14 % in total; men 1.22 % and women 1.07 %), and in the second-generation study 72,545 (1.09 %; men 1.18 % and women 0.99 %). After adjusting for confounders, in first-generation immigrants compared to their Swedish-born counterparts the incidence was somewhat lower among both men (HR 0.92, 0.90-0.96) and women (HR 0.93, 0.90-0.96), and in the second-generation immigrants among women (HR 0.95, 0.92-0.99) but not men (HR 0.99; 0.96–1.02). Among immigrant groups, a higher incidence of epilepsy was observed among first-generation women from Africa and Iraq, and second-generation men and women from Bosnia, and women from Finland. Conclusions: Risk of epilepsy was lower in immigrants in general compared to the Swedish-born population; but with higher incidence in some specific groups.
(Less)
- author
- Wändell, Per LU ; Fredrikson, Sten ; Carlsson, Axel C. ; Li, Xinjun LU ; Gasevic, Danijela ; Sundquist, Jan LU and Sundquist, Kristina LU
- organization
- publishing date
- 2020-03
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Epilepsy, Gender, Immigrants, Neighborhood, Socioeconomic status
- in
- Seizure
- volume
- 76
- pages
- 7 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85079223568
- pmid:32062322
- ISSN
- 1059-1311
- DOI
- 10.1016/j.seizure.2020.02.005
- language
- English
- LU publication?
- yes
- id
- 10aa7f9a-6992-463b-bd0a-88ce7319e12e
- date added to LUP
- 2020-02-20 12:38:56
- date last changed
- 2024-04-03 03:06:26
@article{10aa7f9a-6992-463b-bd0a-88ce7319e12e,
abstract = {{<p>Purpose: We aimed to study the association between country of birth and incident epilepsy in several immigrant groups using Swedish-born individuals as referents. Method: The study population included all adults aged 18 years and older in Sweden, living and deceased, 6,690,598 in the first-generation and 6,683,125 in the second-generation sub-study. Epilepsy was defined as having at least one registered diagnosis of epilepsy in the National Patient Register. The incidence of epilepsy in different immigrant groups, using Swedish-born as referents, was assessed by Cox regression, expressed as hazard ratios (HRs) and 95 % confidence intervals (CI). The models were stratified by sex and adjusted for age, geographical residence in Sweden, educational level, marital status, and neighbourhood socioeconomic status. Results: In the first-generation sub-study, totally 76,541 individuals had at least one registered diagnosis of epilepsy (1.14 % in total; men 1.22 % and women 1.07 %), and in the second-generation study 72,545 (1.09 %; men 1.18 % and women 0.99 %). After adjusting for confounders, in first-generation immigrants compared to their Swedish-born counterparts the incidence was somewhat lower among both men (HR 0.92, 0.90-0.96) and women (HR 0.93, 0.90-0.96), and in the second-generation immigrants among women (HR 0.95, 0.92-0.99) but not men (HR 0.99; 0.96–1.02). Among immigrant groups, a higher incidence of epilepsy was observed among first-generation women from Africa and Iraq, and second-generation men and women from Bosnia, and women from Finland. Conclusions: Risk of epilepsy was lower in immigrants in general compared to the Swedish-born population; but with higher incidence in some specific groups.</p>}},
author = {{Wändell, Per and Fredrikson, Sten and Carlsson, Axel C. and Li, Xinjun and Gasevic, Danijela and Sundquist, Jan and Sundquist, Kristina}},
issn = {{1059-1311}},
keywords = {{Epilepsy; Gender; Immigrants; Neighborhood; Socioeconomic status}},
language = {{eng}},
pages = {{116--122}},
publisher = {{Elsevier}},
series = {{Seizure}},
title = {{Epilepsy in immigrants and Swedish-born : A cohort study of all adults 18 years of age and older in Sweden}},
url = {{http://dx.doi.org/10.1016/j.seizure.2020.02.005}},
doi = {{10.1016/j.seizure.2020.02.005}},
volume = {{76}},
year = {{2020}},
}