Regional cerebral blood flow in conscious stroke-prone spontaneously hypertensive rats
(1984) In Journal of Cerebral Blood Flow and Metabolism 4(1). p.103-106- Abstract
- Regional cerebral blood flow (rCBF) was measured autoradiographically with [14C]iodoantipyrine as a diffusible tracer in two strains of conscious normotensive rats (Wistar Kyoto and local Wistar) and in two groups of spontaneously hypertensive stroke-prone rats (SHRSP) with a mean arterial pressure (MAP) below or above 200 mm Hg. In spite of the large differences in arterial pressure, rCBF did not differ significantly between the hypertensive and the normotensive groups in any of the 14 specified brain structures measured. However, rCBF increased asymmetrically within part of the caudate-putamen in two of nine SHRSP with a MAP above 200 mm Hg, indicating a regional drop in the elevated cerebrovascular resistance.
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https://lup.lub.lu.se/record/1103281
- author
- Fredriksson, K ; Ingvar, M and Johansson, Barbro LU
- organization
- publishing date
- 1984
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Cerebral Blood Flow and Metabolism
- volume
- 4
- issue
- 1
- pages
- 103 - 106
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:6420425
- scopus:0021367083
- ISSN
- 1559-7016
- language
- English
- LU publication?
- yes
- id
- a9605b42-1ad7-448c-b489-bfeac9b42587 (old id 1103281)
- date added to LUP
- 2016-04-01 16:52:13
- date last changed
- 2021-01-03 06:15:26
@article{a9605b42-1ad7-448c-b489-bfeac9b42587, abstract = {{Regional cerebral blood flow (rCBF) was measured autoradiographically with [14C]iodoantipyrine as a diffusible tracer in two strains of conscious normotensive rats (Wistar Kyoto and local Wistar) and in two groups of spontaneously hypertensive stroke-prone rats (SHRSP) with a mean arterial pressure (MAP) below or above 200 mm Hg. In spite of the large differences in arterial pressure, rCBF did not differ significantly between the hypertensive and the normotensive groups in any of the 14 specified brain structures measured. However, rCBF increased asymmetrically within part of the caudate-putamen in two of nine SHRSP with a MAP above 200 mm Hg, indicating a regional drop in the elevated cerebrovascular resistance.}}, author = {{Fredriksson, K and Ingvar, M and Johansson, Barbro}}, issn = {{1559-7016}}, language = {{eng}}, number = {{1}}, pages = {{103--106}}, publisher = {{Nature Publishing Group}}, series = {{Journal of Cerebral Blood Flow and Metabolism}}, title = {{Regional cerebral blood flow in conscious stroke-prone spontaneously hypertensive rats}}, volume = {{4}}, year = {{1984}}, }