Control of traumatic liver hemorrhage in the cirrhotic rat by intraportal infusion of norepinephrine
(1987) In Research in Experimental Medicine 187(5). p.339-346- Abstract
- The effect of intraportal infusion of norepinephrine (NE) on primary hemostasis in the cirrhotic rat was investigated at standardized liver trauma. Cirrhosis was induced by simultaneous administration of increasing amounts of carbontetrachloride (CCl4) and phenobarbitone. Infusion of norepinephrine took place after cannulation of the gastroduodenal vein. Intraportal infusion of NE resulted in a significant increase in arterial blood pressure and portal pressure in all animals. No difference was observed between cirrhotic and control rats. Cirrhotic animals bled longer and more profusely as compared with the controls. Infusion of NE resulted in significant decrease in bleeding time and blood loss. NE did not affect hematocrit, hemoglobin,... (More)
- The effect of intraportal infusion of norepinephrine (NE) on primary hemostasis in the cirrhotic rat was investigated at standardized liver trauma. Cirrhosis was induced by simultaneous administration of increasing amounts of carbontetrachloride (CCl4) and phenobarbitone. Infusion of norepinephrine took place after cannulation of the gastroduodenal vein. Intraportal infusion of NE resulted in a significant increase in arterial blood pressure and portal pressure in all animals. No difference was observed between cirrhotic and control rats. Cirrhotic animals bled longer and more profusely as compared with the controls. Infusion of NE resulted in significant decrease in bleeding time and blood loss. NE did not affect hematocrit, hemoglobin, platelet, or white cell count. Platelet aggregation was not influenced by the compound. In conclusion, intraportal infusion of NE proved effective in decreasing hemorrhage at liver trauma in cirrhotic rats. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1103999
- author
- Vagianos, Constantin ; Steen, Stig LU ; Zoucas, Evita ; Asakawa, H ; Jeppsson, Bengt LU and Bengmark, Stig LU
- organization
- publishing date
- 1987
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cirrhosis, Liver trauma, Hemorrhage, Norepinephrine
- in
- Research in Experimental Medicine
- volume
- 187
- issue
- 5
- pages
- 339 - 346
- publisher
- Springer
- external identifiers
-
- pmid:3432739
- scopus:0023484629
- ISSN
- 0300-9130
- DOI
- 10.1007/BF01855659
- language
- English
- LU publication?
- yes
- id
- d848bbf1-8f4b-4300-9b6b-19e50321e460 (old id 1103999)
- date added to LUP
- 2016-04-01 11:43:35
- date last changed
- 2021-01-03 10:22:44
@article{d848bbf1-8f4b-4300-9b6b-19e50321e460, abstract = {{The effect of intraportal infusion of norepinephrine (NE) on primary hemostasis in the cirrhotic rat was investigated at standardized liver trauma. Cirrhosis was induced by simultaneous administration of increasing amounts of carbontetrachloride (CCl4) and phenobarbitone. Infusion of norepinephrine took place after cannulation of the gastroduodenal vein. Intraportal infusion of NE resulted in a significant increase in arterial blood pressure and portal pressure in all animals. No difference was observed between cirrhotic and control rats. Cirrhotic animals bled longer and more profusely as compared with the controls. Infusion of NE resulted in significant decrease in bleeding time and blood loss. NE did not affect hematocrit, hemoglobin, platelet, or white cell count. Platelet aggregation was not influenced by the compound. In conclusion, intraportal infusion of NE proved effective in decreasing hemorrhage at liver trauma in cirrhotic rats.}}, author = {{Vagianos, Constantin and Steen, Stig and Zoucas, Evita and Asakawa, H and Jeppsson, Bengt and Bengmark, Stig}}, issn = {{0300-9130}}, keywords = {{Cirrhosis; Liver trauma; Hemorrhage; Norepinephrine}}, language = {{eng}}, number = {{5}}, pages = {{339--346}}, publisher = {{Springer}}, series = {{Research in Experimental Medicine}}, title = {{Control of traumatic liver hemorrhage in the cirrhotic rat by intraportal infusion of norepinephrine}}, url = {{http://dx.doi.org/10.1007/BF01855659}}, doi = {{10.1007/BF01855659}}, volume = {{187}}, year = {{1987}}, }