Metabolism and force in hypertrophic smooth muscle from rat urinary bladder
(1990) In American Journal of Physiology: Cell Physiology 258(5 Pt 1). p.923-932- Abstract
- Ten days of urinary outlet obstruction in the rat induced a threefold increase in bladder weight. Active force of control and hypertrophic bladder muscle strips was measured at varying PO2 levels after high-K+, carbachol, or electrical field stimulation. Highest force output was obtained with carbachol. Force per muscle area was lower in the hypertrophic muscles. The basal rates of oxygen consumption and lactate formation were similar in the two groups. The metabolic tension cost (ATP turnover/active force) was similar in the two groups for activation with high K+ and carbachol. In anoxia the active force decreased, but this was less pronounced in the hypertrophied muscle. Hypertrophied muscle could, in contrast to the controls, maintain a... (More)
- Ten days of urinary outlet obstruction in the rat induced a threefold increase in bladder weight. Active force of control and hypertrophic bladder muscle strips was measured at varying PO2 levels after high-K+, carbachol, or electrical field stimulation. Highest force output was obtained with carbachol. Force per muscle area was lower in the hypertrophic muscles. The basal rates of oxygen consumption and lactate formation were similar in the two groups. The metabolic tension cost (ATP turnover/active force) was similar in the two groups for activation with high K+ and carbachol. In anoxia the active force decreased, but this was less pronounced in the hypertrophied muscle. Hypertrophied muscle could, in contrast to the controls, maintain a sustained K+ contracture in anoxia. Basal metabolic rates and tension cost were markedly reduced in anoxia for both groups. The lower force per area with unaltered tension cost, in hypertrophic muscles under all experimental conditions, may reflect unaltered intrinsic properties of the contractile system, although the amount of contractile material has decreased relative to cell volume. The increased resistance to anoxia may reflect a metabolic adaptation to impaired oxygen supply to the hypertrophied tissue. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1105465
- author
- Arner, Anders LU ; Malmqvist, Ulf LU and Uvelius, Bengt LU
- organization
- publishing date
- 1990
- type
- Contribution to journal
- publication status
- published
- subject
- in
- American Journal of Physiology: Cell Physiology
- volume
- 258
- issue
- 5 Pt 1
- pages
- 923 - 932
- publisher
- American Physiological Society
- external identifiers
-
- pmid:2333984
- scopus:0025291550
- ISSN
- 1522-1563
- language
- English
- LU publication?
- yes
- id
- 226c9af8-68c8-4bf0-9cf9-5e71aa056766 (old id 1105465)
- alternative location
- http://ajpcell.physiology.org/cgi/reprint/258/5/C923
- date added to LUP
- 2016-04-01 17:03:31
- date last changed
- 2021-12-23 08:14:48
@article{226c9af8-68c8-4bf0-9cf9-5e71aa056766,
abstract = {{Ten days of urinary outlet obstruction in the rat induced a threefold increase in bladder weight. Active force of control and hypertrophic bladder muscle strips was measured at varying PO2 levels after high-K+, carbachol, or electrical field stimulation. Highest force output was obtained with carbachol. Force per muscle area was lower in the hypertrophic muscles. The basal rates of oxygen consumption and lactate formation were similar in the two groups. The metabolic tension cost (ATP turnover/active force) was similar in the two groups for activation with high K+ and carbachol. In anoxia the active force decreased, but this was less pronounced in the hypertrophied muscle. Hypertrophied muscle could, in contrast to the controls, maintain a sustained K+ contracture in anoxia. Basal metabolic rates and tension cost were markedly reduced in anoxia for both groups. The lower force per area with unaltered tension cost, in hypertrophic muscles under all experimental conditions, may reflect unaltered intrinsic properties of the contractile system, although the amount of contractile material has decreased relative to cell volume. The increased resistance to anoxia may reflect a metabolic adaptation to impaired oxygen supply to the hypertrophied tissue.}},
author = {{Arner, Anders and Malmqvist, Ulf and Uvelius, Bengt}},
issn = {{1522-1563}},
language = {{eng}},
number = {{5 Pt 1}},
pages = {{923--932}},
publisher = {{American Physiological Society}},
series = {{American Journal of Physiology: Cell Physiology}},
title = {{Metabolism and force in hypertrophic smooth muscle from rat urinary bladder}},
url = {{http://ajpcell.physiology.org/cgi/reprint/258/5/C923}},
volume = {{258}},
year = {{1990}},
}