The effect of neuropeptide Y on mucociliary activity in the rabbit maxillary sinus
(1991) In Acta Oto-Laryngologica 111(5). p.960-966- Abstract
- The effect of neuropeptide Y (NPY) on mucociliary activity in the rabbit maxillary sinus was investigated in vivo by injecting NPY at increasing dosages into the maxillary artery, response being recorded photoelectrically. At dosages of 0.1-5.0 micrograms/kg, NPY reduced mucociliary activity dose-dependently, the maximum decrease being 14.6 +/- 1.8%, at a dosage of 5.0 micrograms/kg. The NPY-induced reduction of the mucociliary activity manifested brief latency, the peak effect occurring within 3 min followed by a slow return to the baseline value 4-9 min after injection. The response of mucociliary activity to NPY remained unaffected by pretreatment with the alpha-adrenergic antagonists yohimbine (alpha 2) at 100.0 micrograms/kg and... (More)
- The effect of neuropeptide Y (NPY) on mucociliary activity in the rabbit maxillary sinus was investigated in vivo by injecting NPY at increasing dosages into the maxillary artery, response being recorded photoelectrically. At dosages of 0.1-5.0 micrograms/kg, NPY reduced mucociliary activity dose-dependently, the maximum decrease being 14.6 +/- 1.8%, at a dosage of 5.0 micrograms/kg. The NPY-induced reduction of the mucociliary activity manifested brief latency, the peak effect occurring within 3 min followed by a slow return to the baseline value 4-9 min after injection. The response of mucociliary activity to NPY remained unaffected by pretreatment with the alpha-adrenergic antagonists yohimbine (alpha 2) at 100.0 micrograms/kg and phentolamine (alpha 1 + alpha 2) at 0.2-1.0 mg/kg, indicating that the effect of NPY is not mediated via alpha-receptors. Pretreatment with the calcium antagonist nifedipine at 100.0 micrograms/kg inhibited the effect of NPY, suggesting that the NPY-induced decrease may be calcium dependent. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1105749
- author
- Cervin, Anders LU ; Lindberg, Sven LU and Mercke, Ulf LU
- organization
- publishing date
- 1991
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Oto-Laryngologica
- volume
- 111
- issue
- 5
- pages
- 960 - 966
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:1684689
- scopus:0026070045
- ISSN
- 1651-2251
- language
- English
- LU publication?
- yes
- id
- a274d7f9-a1d8-4010-8329-6eb1031d0986 (old id 1105749)
- date added to LUP
- 2016-04-01 15:29:30
- date last changed
- 2021-10-03 04:35:07
@article{a274d7f9-a1d8-4010-8329-6eb1031d0986,
abstract = {{The effect of neuropeptide Y (NPY) on mucociliary activity in the rabbit maxillary sinus was investigated in vivo by injecting NPY at increasing dosages into the maxillary artery, response being recorded photoelectrically. At dosages of 0.1-5.0 micrograms/kg, NPY reduced mucociliary activity dose-dependently, the maximum decrease being 14.6 +/- 1.8%, at a dosage of 5.0 micrograms/kg. The NPY-induced reduction of the mucociliary activity manifested brief latency, the peak effect occurring within 3 min followed by a slow return to the baseline value 4-9 min after injection. The response of mucociliary activity to NPY remained unaffected by pretreatment with the alpha-adrenergic antagonists yohimbine (alpha 2) at 100.0 micrograms/kg and phentolamine (alpha 1 + alpha 2) at 0.2-1.0 mg/kg, indicating that the effect of NPY is not mediated via alpha-receptors. Pretreatment with the calcium antagonist nifedipine at 100.0 micrograms/kg inhibited the effect of NPY, suggesting that the NPY-induced decrease may be calcium dependent.}},
author = {{Cervin, Anders and Lindberg, Sven and Mercke, Ulf}},
issn = {{1651-2251}},
language = {{eng}},
number = {{5}},
pages = {{960--966}},
publisher = {{Taylor & Francis}},
series = {{Acta Oto-Laryngologica}},
title = {{The effect of neuropeptide Y on mucociliary activity in the rabbit maxillary sinus}},
volume = {{111}},
year = {{1991}},
}