Occupational exposure to hexahydrophthalic anhydride: air analysis, percutaneous absorption, and biological monitoring
(1993) In International Archives of Occupational and Environmental Health 65(1). p.43-47- Abstract
- Urinary hexahydrophthalic acid (HHP acid) levels were determined in 20 workers occupationally exposed to hexahydrophthalic anhydride (HHPA) air levels of 11-220 micrograms/m3. The levels of HHP acid in urine increased rapidly during exposure and the decreases were also rapid after the end of exposure. The elimination half-time of HHP acid was 5 h, which was significantly longer than in experimentally exposed volunteers, possibly indicating distribution to more than one compartment. There was a close correlation between time-weighted average levels of HHPA in air and creatinine-adjusted levels of HHP acid in urine collected during the last 4 h of exposure (r = 0.90), indicating that determination of urinary HHP acid levels is suitable as a... (More)
- Urinary hexahydrophthalic acid (HHP acid) levels were determined in 20 workers occupationally exposed to hexahydrophthalic anhydride (HHPA) air levels of 11-220 micrograms/m3. The levels of HHP acid in urine increased rapidly during exposure and the decreases were also rapid after the end of exposure. The elimination half-time of HHP acid was 5 h, which was significantly longer than in experimentally exposed volunteers, possibly indicating distribution to more than one compartment. There was a close correlation between time-weighted average levels of HHPA in air and creatinine-adjusted levels of HHP acid in urine collected during the last 4 h of exposure (r = 0.90), indicating that determination of urinary HHP acid levels is suitable as a method for biological monitoring of HHPA exposure. An air level of 100 micrograms/m3 corresponded to a postshift urinary HHP acid level of ca. 900 nmol/mmol creatinine in subjects performing light work for 8 h. Percutaneous absorption of HHPA was studied by application of HHPA in petrolatum to the back skin of three volunteers. The excreted amounts of HHP acid in urine, as a fraction of the totally applied amount of HHPA, were within intervals of 1.4%-4.5%, 0.2%-1.3%, and 0%-0.4% respectively, indicating that the contribution from percutaneous absorption is of minor importance in a method for biological monitoring. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1107096
- author
- Jönsson, Bo A LU ; Welinder, Hans LU ; Hansson, Christer LU and Stahlbom, B
- organization
- publishing date
- 1993
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Hexahydrophthalic anhydride, Hexahydrophthalic acid, Urine, Skin absorption, Biological monitoring
- in
- International Archives of Occupational and Environmental Health
- volume
- 65
- issue
- 1
- pages
- 43 - 47
- publisher
- Springer
- external identifiers
-
- pmid:8354574
- scopus:0027508177
- ISSN
- 1432-1246
- DOI
- 10.1007/BF00586057
- language
- English
- LU publication?
- yes
- id
- 34ba5f85-246a-44df-ad2a-294e6bd6903f (old id 1107096)
- date added to LUP
- 2016-04-01 17:00:39
- date last changed
- 2021-01-03 09:44:48
@article{34ba5f85-246a-44df-ad2a-294e6bd6903f, abstract = {{Urinary hexahydrophthalic acid (HHP acid) levels were determined in 20 workers occupationally exposed to hexahydrophthalic anhydride (HHPA) air levels of 11-220 micrograms/m3. The levels of HHP acid in urine increased rapidly during exposure and the decreases were also rapid after the end of exposure. The elimination half-time of HHP acid was 5 h, which was significantly longer than in experimentally exposed volunteers, possibly indicating distribution to more than one compartment. There was a close correlation between time-weighted average levels of HHPA in air and creatinine-adjusted levels of HHP acid in urine collected during the last 4 h of exposure (r = 0.90), indicating that determination of urinary HHP acid levels is suitable as a method for biological monitoring of HHPA exposure. An air level of 100 micrograms/m3 corresponded to a postshift urinary HHP acid level of ca. 900 nmol/mmol creatinine in subjects performing light work for 8 h. Percutaneous absorption of HHPA was studied by application of HHPA in petrolatum to the back skin of three volunteers. The excreted amounts of HHP acid in urine, as a fraction of the totally applied amount of HHPA, were within intervals of 1.4%-4.5%, 0.2%-1.3%, and 0%-0.4% respectively, indicating that the contribution from percutaneous absorption is of minor importance in a method for biological monitoring.}}, author = {{Jönsson, Bo A and Welinder, Hans and Hansson, Christer and Stahlbom, B}}, issn = {{1432-1246}}, keywords = {{Hexahydrophthalic anhydride; Hexahydrophthalic acid; Urine; Skin absorption; Biological monitoring}}, language = {{eng}}, number = {{1}}, pages = {{43--47}}, publisher = {{Springer}}, series = {{International Archives of Occupational and Environmental Health}}, title = {{Occupational exposure to hexahydrophthalic anhydride: air analysis, percutaneous absorption, and biological monitoring}}, url = {{http://dx.doi.org/10.1007/BF00586057}}, doi = {{10.1007/BF00586057}}, volume = {{65}}, year = {{1993}}, }