Inhibition of [methyl-3H]diazepam binding to rat brain membranes in vitro by dinatin and skrofulein
(1994) In Zhongguo Yaoli Xuebao (China) 15(5). p.385-388- Abstract
- Two flavones, 4',5,7-trihydroxy-6-methoxy flavone (dinatin) and 4',5-dihydroxy-6, 7-dimethoxy flavone (skrofulein), were extracted from Artemisia herba alba L. Dinatin and skrofulein inhibited the binding of [methyl-3H]diazepam to rat brain membranes in vitro with IC50 of 1.3 and 23 mumol.L-1, respectively. The GABA-ratios (the ratio of IC50 values in the absence/presence of GABA in the binding assay) were 1.1 and 1.2 for dinatin and skrofulein, respectively. Both flavones induced a slight increase in [35S] TBPS binding. The data suggest that the flavones are antagonists or partial agonists of benzodiazepine receptors.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1108261
- author
- Shen, X L ; Nielsen, M ; Witt, M R ; Sterner, Olov LU ; Bergendorff, Ola LU and Khayyal, M
- organization
- publishing date
- 1994
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Zhongguo Yaoli Xuebao (China)
- volume
- 15
- issue
- 5
- pages
- 385 - 388
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:7717057
- scopus:0028024756
- ISSN
- 0253-9756
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240), Department of Dermatology and Venereology (Lund) (013006000)
- id
- 686438fe-2b43-43f3-bf5d-c3667f8648b7 (old id 1108261)
- date added to LUP
- 2016-04-01 15:47:53
- date last changed
- 2021-01-03 11:03:36
@article{686438fe-2b43-43f3-bf5d-c3667f8648b7, abstract = {{Two flavones, 4',5,7-trihydroxy-6-methoxy flavone (dinatin) and 4',5-dihydroxy-6, 7-dimethoxy flavone (skrofulein), were extracted from Artemisia herba alba L. Dinatin and skrofulein inhibited the binding of [methyl-3H]diazepam to rat brain membranes in vitro with IC50 of 1.3 and 23 mumol.L-1, respectively. The GABA-ratios (the ratio of IC50 values in the absence/presence of GABA in the binding assay) were 1.1 and 1.2 for dinatin and skrofulein, respectively. Both flavones induced a slight increase in [35S] TBPS binding. The data suggest that the flavones are antagonists or partial agonists of benzodiazepine receptors.}}, author = {{Shen, X L and Nielsen, M and Witt, M R and Sterner, Olov and Bergendorff, Ola and Khayyal, M}}, issn = {{0253-9756}}, language = {{eng}}, number = {{5}}, pages = {{385--388}}, publisher = {{Nature Publishing Group}}, series = {{Zhongguo Yaoli Xuebao (China)}}, title = {{Inhibition of [methyl-3H]diazepam binding to rat brain membranes in vitro by dinatin and skrofulein}}, volume = {{15}}, year = {{1994}}, }