Serum concentrations of C4 isotypes and factor B in type I C2 deficiency suggest haplotype-dependent quantitative expression of MHC class III complement genes
(1995) In Experimental and Clinical Immunogenetics 12(2). p.66-73- Abstract
- The complement protein C4 exists as two isotypes, C4A and C4B, encoded by genes in the major histocompatibility complex (MHC) class III region. The serum concentrations of C4A4 were lower than those of C4B2 in serum from 19 individuals homozygous for type I C2 deficiency (p < 0.0002). These individuals all had the S042 complotype and most of them were homozygous for the haplotype HLA-B18,S042,DR2. In 14 individuals heterozygous for the C2Q0 gene and with the C4A4, C4B2 phenotype and in 51 individuals with the C4A3, C4B1 phenotype, the isotype concentrations were equal. Factor B concentrations in the C2-deficient individuals were lower than those in individuals with the C4A3, C4B1 phenotype (p < 0.0001). The findings strongly suggest... (More)
- The complement protein C4 exists as two isotypes, C4A and C4B, encoded by genes in the major histocompatibility complex (MHC) class III region. The serum concentrations of C4A4 were lower than those of C4B2 in serum from 19 individuals homozygous for type I C2 deficiency (p < 0.0002). These individuals all had the S042 complotype and most of them were homozygous for the haplotype HLA-B18,S042,DR2. In 14 individuals heterozygous for the C2Q0 gene and with the C4A4, C4B2 phenotype and in 51 individuals with the C4A3, C4B1 phenotype, the isotype concentrations were equal. Factor B concentrations in the C2-deficient individuals were lower than those in individuals with the C4A3, C4B1 phenotype (p < 0.0001). The findings strongly suggest that the quantitative expression of C4 isotypes and factor B is MHC haplotype dependent. C4 null alleles cannot be accurately determined by measuring relative C4 isotype serum concentrations. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1109329
- author
- Truedsson, Lennart LU ; Gullstrand, Birgitta LU ; Jonsson, T and Klint, Cecilia LU
- organization
- publishing date
- 1995
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Experimental and Clinical Immunogenetics
- volume
- 12
- issue
- 2
- pages
- 66 - 73
- publisher
- Karger
- external identifiers
-
- pmid:7576717
- scopus:0029055825
- ISSN
- 0254-9670
- language
- English
- LU publication?
- yes
- id
- 4114cc6a-cffe-4703-abdd-10c133eebfcc (old id 1109329)
- date added to LUP
- 2016-04-01 16:39:35
- date last changed
- 2021-01-03 06:55:57
@article{4114cc6a-cffe-4703-abdd-10c133eebfcc,
abstract = {{The complement protein C4 exists as two isotypes, C4A and C4B, encoded by genes in the major histocompatibility complex (MHC) class III region. The serum concentrations of C4A4 were lower than those of C4B2 in serum from 19 individuals homozygous for type I C2 deficiency (p < 0.0002). These individuals all had the S042 complotype and most of them were homozygous for the haplotype HLA-B18,S042,DR2. In 14 individuals heterozygous for the C2Q0 gene and with the C4A4, C4B2 phenotype and in 51 individuals with the C4A3, C4B1 phenotype, the isotype concentrations were equal. Factor B concentrations in the C2-deficient individuals were lower than those in individuals with the C4A3, C4B1 phenotype (p < 0.0001). The findings strongly suggest that the quantitative expression of C4 isotypes and factor B is MHC haplotype dependent. C4 null alleles cannot be accurately determined by measuring relative C4 isotype serum concentrations.}},
author = {{Truedsson, Lennart and Gullstrand, Birgitta and Jonsson, T and Klint, Cecilia}},
issn = {{0254-9670}},
language = {{eng}},
number = {{2}},
pages = {{66--73}},
publisher = {{Karger}},
series = {{Experimental and Clinical Immunogenetics}},
title = {{Serum concentrations of C4 isotypes and factor B in type I C2 deficiency suggest haplotype-dependent quantitative expression of MHC class III complement genes}},
volume = {{12}},
year = {{1995}},
}