Identification of TP53 gene mutations in uterine corpus cancer with short follow-up
(1997) In Gynecologic Oncology 67(3). p.295-302- Abstract
- The involvement of the TP53 tumor suppressor gene in uterine corpus cancer was investigated by single-stranded conformation polymorphism and sequence analysis of its exons 4 to 10. Mutations were found in 12 (18.5%) of 65 cases. Ten of these 12 were single-base substitutions (8 missense and 2 nonsense mutations), whereas 2 were frame-shifting mutations. TP53 gene mutations correlated significantly with advanced surgical stage of disease (P = 0.006) and unfavorable tumor histology types (P = 0.003), whereas the association to myometrial wall invasion did not reach statistical significance (P = 0.054). TP53 gene mutations also correlated significantly with allelic loss at TP53 locus (P = 0.024), absence of estrogen (P = 0.045) and... (More)
- The involvement of the TP53 tumor suppressor gene in uterine corpus cancer was investigated by single-stranded conformation polymorphism and sequence analysis of its exons 4 to 10. Mutations were found in 12 (18.5%) of 65 cases. Ten of these 12 were single-base substitutions (8 missense and 2 nonsense mutations), whereas 2 were frame-shifting mutations. TP53 gene mutations correlated significantly with advanced surgical stage of disease (P = 0.006) and unfavorable tumor histology types (P = 0.003), whereas the association to myometrial wall invasion did not reach statistical significance (P = 0.054). TP53 gene mutations also correlated significantly with allelic loss at TP53 locus (P = 0.024), absence of estrogen (P = 0.045) and progesterone receptors (P = 0.001), DNA nondiploidy (P = 0.002), and high S-phase fraction values (P = 0.002). Our results suggest that inactivation of the TP53 checkpoint function is associated with disease transition into a stage of rapid progression and spread. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1111538
- author
- Koul, Anjila LU ; Borg, Åke LU ; Pejovic, Tanja ; Bendahl, Pär-Ola LU ; Högberg, Thomas LU ; Iosif, Constantin LU and Killander, Dick LU
- organization
- publishing date
- 1997
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- TP53, mutation, uterine corpus cancer, DNA ploidy
- in
- Gynecologic Oncology
- volume
- 67
- issue
- 3
- pages
- 295 - 302
- publisher
- Academic Press
- external identifiers
-
- pmid:9441778
- scopus:0031439934
- ISSN
- 1095-6859
- DOI
- 10.1006/gyno.1997.4859
- language
- English
- LU publication?
- yes
- id
- 603a6656-cd6e-490d-b7e1-f1dd38057c6f (old id 1111538)
- date added to LUP
- 2016-04-01 12:00:36
- date last changed
- 2022-01-26 21:28:30
@article{603a6656-cd6e-490d-b7e1-f1dd38057c6f, abstract = {{The involvement of the TP53 tumor suppressor gene in uterine corpus cancer was investigated by single-stranded conformation polymorphism and sequence analysis of its exons 4 to 10. Mutations were found in 12 (18.5%) of 65 cases. Ten of these 12 were single-base substitutions (8 missense and 2 nonsense mutations), whereas 2 were frame-shifting mutations. TP53 gene mutations correlated significantly with advanced surgical stage of disease (P = 0.006) and unfavorable tumor histology types (P = 0.003), whereas the association to myometrial wall invasion did not reach statistical significance (P = 0.054). TP53 gene mutations also correlated significantly with allelic loss at TP53 locus (P = 0.024), absence of estrogen (P = 0.045) and progesterone receptors (P = 0.001), DNA nondiploidy (P = 0.002), and high S-phase fraction values (P = 0.002). Our results suggest that inactivation of the TP53 checkpoint function is associated with disease transition into a stage of rapid progression and spread.}}, author = {{Koul, Anjila and Borg, Åke and Pejovic, Tanja and Bendahl, Pär-Ola and Högberg, Thomas and Iosif, Constantin and Killander, Dick}}, issn = {{1095-6859}}, keywords = {{TP53; mutation; uterine corpus cancer; DNA ploidy}}, language = {{eng}}, number = {{3}}, pages = {{295--302}}, publisher = {{Academic Press}}, series = {{Gynecologic Oncology}}, title = {{Identification of TP53 gene mutations in uterine corpus cancer with short follow-up}}, url = {{http://dx.doi.org/10.1006/gyno.1997.4859}}, doi = {{10.1006/gyno.1997.4859}}, volume = {{67}}, year = {{1997}}, }