Pharmacokinetics of Na2B12H11SH (BSH) in patients with malignant brain tumours as prerequisite for a phase I clinical trial of boron neutron capture
(1997) In Acta Neurochirurgica 139(7). p.606-612- Abstract
- The disposition of Na2B12H11SH (BSH) in patients with malignant glioma has been investigated, in preparation for a Phase I clinical trial of boron neutron capture therapy. BSH was found to possess a linear disposition over the dosage interval investigated (up to 75 mg/kg). A bi-phasic blood pharmacokinetics was observed. Tumour-to-blood ratios showed variations between patients between 0.08 and 5.1. The data allow the definition of amount of BSH and timing of infusion for a Phase I clinical trial protocol.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1112148
- author
- Gabel, D ; Preusse, D ; Haritz, D ; Grochulla, F ; Haselsberger, K ; Fankhauser, H ; Ceberg, Crister LU ; Peters, H D and Klotz, U
- organization
- publishing date
- 1997
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Boron neutron capture therapy, glioma, BSH
- in
- Acta Neurochirurgica
- volume
- 139
- issue
- 7
- pages
- 606 - 612
- publisher
- Springer
- external identifiers
-
- pmid:9265952
- scopus:0030752312
- ISSN
- 0001-6268
- DOI
- 10.1007/BF01411994
- language
- English
- LU publication?
- yes
- id
- 13ef977a-5e03-417b-854d-7363405d0f12 (old id 1112148)
- date added to LUP
- 2016-04-01 17:03:08
- date last changed
- 2022-03-22 23:01:36
@article{13ef977a-5e03-417b-854d-7363405d0f12, abstract = {{The disposition of Na2B12H11SH (BSH) in patients with malignant glioma has been investigated, in preparation for a Phase I clinical trial of boron neutron capture therapy. BSH was found to possess a linear disposition over the dosage interval investigated (up to 75 mg/kg). A bi-phasic blood pharmacokinetics was observed. Tumour-to-blood ratios showed variations between patients between 0.08 and 5.1. The data allow the definition of amount of BSH and timing of infusion for a Phase I clinical trial protocol.}}, author = {{Gabel, D and Preusse, D and Haritz, D and Grochulla, F and Haselsberger, K and Fankhauser, H and Ceberg, Crister and Peters, H D and Klotz, U}}, issn = {{0001-6268}}, keywords = {{Boron neutron capture therapy; glioma; BSH}}, language = {{eng}}, number = {{7}}, pages = {{606--612}}, publisher = {{Springer}}, series = {{Acta Neurochirurgica}}, title = {{Pharmacokinetics of Na2B12H11SH (BSH) in patients with malignant brain tumours as prerequisite for a phase I clinical trial of boron neutron capture}}, url = {{http://dx.doi.org/10.1007/BF01411994}}, doi = {{10.1007/BF01411994}}, volume = {{139}}, year = {{1997}}, }