5-Hydroxytryptamine contracts human uterine artery smooth muscle predominantly via 5-HT2 receptors
(1997) In Human Reproduction 12(2). p.361-367- Abstract
- Serotonergic receptors were classified in the isolated human uterine artery with intact endothelium, using agonists and antagonists for 5-hydroxytryptamine (5-HT) receptors. The efficacy for different agonists rated: alpha-methyl-5-HT (5-HT2) = 5-HT (non-selective) = 2-methyl-5-HT (5-HT3) >> sumatriptan (5-HT1), and the potency as: sumatriptan = 5-HT > 5-HT > alpha-methyl-5-HT > 2-methyl-5-HT. The contractile effects of 5-HT and alpha-methyl-5-HT were antagonized by the 5-HT2 receptor antagonist ketanserin and the non-selective antagonist methiothepin. The efficacy of sumatriptan was comparatively low. No interaction was encountered between 2-methyl-5-HT and MDL72222, suggesting an absence of 5-HT3 receptors. The results... (More)
- Serotonergic receptors were classified in the isolated human uterine artery with intact endothelium, using agonists and antagonists for 5-hydroxytryptamine (5-HT) receptors. The efficacy for different agonists rated: alpha-methyl-5-HT (5-HT2) = 5-HT (non-selective) = 2-methyl-5-HT (5-HT3) >> sumatriptan (5-HT1), and the potency as: sumatriptan = 5-HT > 5-HT > alpha-methyl-5-HT > 2-methyl-5-HT. The contractile effects of 5-HT and alpha-methyl-5-HT were antagonized by the 5-HT2 receptor antagonist ketanserin and the non-selective antagonist methiothepin. The efficacy of sumatriptan was comparatively low. No interaction was encountered between 2-methyl-5-HT and MDL72222, suggesting an absence of 5-HT3 receptors. The results indicate that the contractile serotonergic receptor population in the human uterine artery mainly comprises 5-HT2 receptors, although a minor contribution of contractile 5-HT1 receptors cannot be excluded. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1112382
- author
- Karlsson, Caroline LU ; Bodelsson, Gunilla LU ; Bodelsson, Mikael LU and Stjernquist, Martin LU
- organization
- publishing date
- 1997
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- 5-HT (5-hydroxytryptamine, serotonin)/5-HT properties and linked second messenger systems, the 5-HT receptors/smooth muscle/uterine artery (human)
- in
- Human Reproduction
- volume
- 12
- issue
- 2
- pages
- 361 - 367
- publisher
- Oxford University Press
- external identifiers
-
- pmid:9070726
- scopus:0030993824
- ISSN
- 0268-1161
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pediatrics/Urology/Gynecology/Endocrinology (013240400), Preventive Paediatrics (013243030), Division of Infection Medicine (BMC) (013024020), Research Unit for Urogynaecology and Reproductive Pharmacology (013242710)
- id
- b79672f5-2067-481b-9c9d-1544dbe9b27f (old id 1112382)
- alternative location
- http://humrep.oxfordjournals.org/cgi/reprint/12/2/361
- date added to LUP
- 2016-04-01 12:31:55
- date last changed
- 2022-02-03 23:29:02
@article{b79672f5-2067-481b-9c9d-1544dbe9b27f, abstract = {{Serotonergic receptors were classified in the isolated human uterine artery with intact endothelium, using agonists and antagonists for 5-hydroxytryptamine (5-HT) receptors. The efficacy for different agonists rated: alpha-methyl-5-HT (5-HT2) = 5-HT (non-selective) = 2-methyl-5-HT (5-HT3) >> sumatriptan (5-HT1), and the potency as: sumatriptan = 5-HT > 5-HT > alpha-methyl-5-HT > 2-methyl-5-HT. The contractile effects of 5-HT and alpha-methyl-5-HT were antagonized by the 5-HT2 receptor antagonist ketanserin and the non-selective antagonist methiothepin. The efficacy of sumatriptan was comparatively low. No interaction was encountered between 2-methyl-5-HT and MDL72222, suggesting an absence of 5-HT3 receptors. The results indicate that the contractile serotonergic receptor population in the human uterine artery mainly comprises 5-HT2 receptors, although a minor contribution of contractile 5-HT1 receptors cannot be excluded.}}, author = {{Karlsson, Caroline and Bodelsson, Gunilla and Bodelsson, Mikael and Stjernquist, Martin}}, issn = {{0268-1161}}, keywords = {{5-HT (5-hydroxytryptamine; serotonin)/5-HT properties and linked second messenger systems; the 5-HT receptors/smooth muscle/uterine artery (human)}}, language = {{eng}}, number = {{2}}, pages = {{361--367}}, publisher = {{Oxford University Press}}, series = {{Human Reproduction}}, title = {{5-Hydroxytryptamine contracts human uterine artery smooth muscle predominantly via 5-HT2 receptors}}, url = {{http://humrep.oxfordjournals.org/cgi/reprint/12/2/361}}, volume = {{12}}, year = {{1997}}, }