The peritoneal microcirculation in peritoneal dialysis
(2001) In Microcirculation 8(5). p.303-320- Abstract
- This paper deals with the peritoneal microcirculation and with peritoneal exchange occurring in peritoneal dialysis (PD). The capillary wall is a major barrier to solute and water exchange across the peritoneal membrane. There is a bimodal size-selectivity of solute transport between blood and the peritoneal cavity, through pores of radius approximately 40-50 A as well as through a very low number of large pores of radius approximately 250 A. Furthermore, during glucose-induced osmosis during PD, nearly 40% of the total osmotic water flow occurs through molecular water channels, termed "aquaporin-1." This causes an inequality between 1 - sigma and the sieving coefficient for small solutes, which is a key feature of the "three-pore model"... (More)
- This paper deals with the peritoneal microcirculation and with peritoneal exchange occurring in peritoneal dialysis (PD). The capillary wall is a major barrier to solute and water exchange across the peritoneal membrane. There is a bimodal size-selectivity of solute transport between blood and the peritoneal cavity, through pores of radius approximately 40-50 A as well as through a very low number of large pores of radius approximately 250 A. Furthermore, during glucose-induced osmosis during PD, nearly 40% of the total osmotic water flow occurs through molecular water channels, termed "aquaporin-1." This causes an inequality between 1 - sigma and the sieving coefficient for small solutes, which is a key feature of the "three-pore model" of peritoneal transport. The peritoneal interstitium, coupled in series with the capillary walls, markedly modifies small-solute transport and makes large-solute transport asymmetric. Thus, although severely restricted in the blood-to-peritoneal direction, the absorption of large solutes from the peritoneal cavity occurs at a high clearance rate ( approximately 1 mL/min), largely independent of molecular radius. True absorption of macromolecules to the blood via lymphatics, however, seems to be occurring at a rate of approximately 0.2 mL/min. Several controversial issues regarding transcapillary and transperitoneal exchange mechanisms are discussed in this paper. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1119843
- author
- Rippe, Bengt LU ; Rosengren, B I and Venturoli, Daniele LU
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Microcirculation
- volume
- 8
- issue
- 5
- pages
- 303 - 320
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:11687943
- scopus:0035486937
- pmid:11687943
- ISSN
- 1549-8719
- DOI
- 10.1038/sj/mn/7800106
- language
- English
- LU publication?
- yes
- id
- 2f83ea77-5a44-4efd-99e9-d2f9e3da06cc (old id 1119843)
- date added to LUP
- 2016-04-01 12:19:02
- date last changed
- 2022-02-18 20:55:10
@article{2f83ea77-5a44-4efd-99e9-d2f9e3da06cc,
abstract = {{This paper deals with the peritoneal microcirculation and with peritoneal exchange occurring in peritoneal dialysis (PD). The capillary wall is a major barrier to solute and water exchange across the peritoneal membrane. There is a bimodal size-selectivity of solute transport between blood and the peritoneal cavity, through pores of radius approximately 40-50 A as well as through a very low number of large pores of radius approximately 250 A. Furthermore, during glucose-induced osmosis during PD, nearly 40% of the total osmotic water flow occurs through molecular water channels, termed "aquaporin-1." This causes an inequality between 1 - sigma and the sieving coefficient for small solutes, which is a key feature of the "three-pore model" of peritoneal transport. The peritoneal interstitium, coupled in series with the capillary walls, markedly modifies small-solute transport and makes large-solute transport asymmetric. Thus, although severely restricted in the blood-to-peritoneal direction, the absorption of large solutes from the peritoneal cavity occurs at a high clearance rate ( approximately 1 mL/min), largely independent of molecular radius. True absorption of macromolecules to the blood via lymphatics, however, seems to be occurring at a rate of approximately 0.2 mL/min. Several controversial issues regarding transcapillary and transperitoneal exchange mechanisms are discussed in this paper.}},
author = {{Rippe, Bengt and Rosengren, B I and Venturoli, Daniele}},
issn = {{1549-8719}},
language = {{eng}},
number = {{5}},
pages = {{303--320}},
publisher = {{Taylor & Francis}},
series = {{Microcirculation}},
title = {{The peritoneal microcirculation in peritoneal dialysis}},
url = {{http://dx.doi.org/10.1038/sj/mn/7800106}},
doi = {{10.1038/sj/mn/7800106}},
volume = {{8}},
year = {{2001}},
}