Toward clinical application of prompt gamma spectroscopy for in vivo monitoring of boron uptake in boron neutron capture therapy
Munck af Rosenschöld, Per LU
; Verbakel, W.
; Ceberg, Crister
LU
; Stecher-Rasmussen, F.
and Persson, Bertil R
LU
(2001)
In Medical Physics
28(5).
p.787-795
- Abstract
- In boron neutron capture therapy (BNCT) the absorbed dose to the tumor cells and healthy tissues depends critically on the boron uptake. Pronounced individual variations in the uptake patterns have been observed for two boron compounds currently used in clinical trials. This implies a high uncertainty in the determination of the boron dose component. Ln the present work a technique known as prompt gamma spectroscopy (PGS) is studied that potentially can be used for in vivo and noninvasive boron concentration determination at the time of the treatment. The technique is based upon measurement of gamma rays promptly emitted in the B-10(n, alpha)Li-7 and H-1(n, gamma)D-2 reactions. The aim of this work is to prepare the present setup for... (More)
- In boron neutron capture therapy (BNCT) the absorbed dose to the tumor cells and healthy tissues depends critically on the boron uptake. Pronounced individual variations in the uptake patterns have been observed for two boron compounds currently used in clinical trials. This implies a high uncertainty in the determination of the boron dose component. Ln the present work a technique known as prompt gamma spectroscopy (PGS) is studied that potentially can be used for in vivo and noninvasive boron concentration determination at the time of the treatment. The technique is based upon measurement of gamma rays promptly emitted in the B-10(n, alpha)Li-7 and H-1(n, gamma)D-2 reactions. The aim of this work is to prepare the present setup for clinical application as a monitor of boron uptake in BNCT patients. Therefore, a full calibration and a set of phantom experiments were performed in a clinical setting. Specifically, a nonuniform boron distribution was studied; a skin/dura, a larger blood vessel, and tumor within a head phantom was simulated. The results show that it is possible to determine a homogeneous boron concentration of 5 mug/g within +/-3% (1 standard deviation). In the nonuniform case, this work shows that the boron concentration can be determined through a multistep measurement procedure, however, with a somewhat higher uncertainty (similar to 10%). The present work forms the basis for a subsequent clinical application of the PGS setup aimed at in vivo monitoring of boron uptake. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1122176
- author
- Munck af Rosenschöld, Per
LU
; Verbakel, W.
; Ceberg, Crister
LU
; Stecher-Rasmussen, F.
and Persson, Bertil R
LU
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- BNCT, Boron measurements, Gamma-ray telescope, In vivo dosimetry, Prompt gamma spectroscopy
- in
- Medical Physics
- volume
- 28
- issue
- 5
- pages
- 9 pages
- publisher
- American Association of Physicists in Medicine
- external identifiers
-
- scopus:0034999602
- pmid:11393474
- ISSN
- 0094-2405
- DOI
- 10.1118/1.1367281
- language
- English
- LU publication?
- no
- id
- 6e8eadba-7c92-4036-bf35-75a2835cf231 (old id 1122176)
- date added to LUP
- 2016-04-01 16:48:25
- date last changed
- 2023-07-20 08:34:39
@article{6e8eadba-7c92-4036-bf35-75a2835cf231,
abstract = {{In boron neutron capture therapy (BNCT) the absorbed dose to the tumor cells and healthy tissues depends critically on the boron uptake. Pronounced individual variations in the uptake patterns have been observed for two boron compounds currently used in clinical trials. This implies a high uncertainty in the determination of the boron dose component. Ln the present work a technique known as prompt gamma spectroscopy (PGS) is studied that potentially can be used for in vivo and noninvasive boron concentration determination at the time of the treatment. The technique is based upon measurement of gamma rays promptly emitted in the B-10(n, alpha)Li-7 and H-1(n, gamma)D-2 reactions. The aim of this work is to prepare the present setup for clinical application as a monitor of boron uptake in BNCT patients. Therefore, a full calibration and a set of phantom experiments were performed in a clinical setting. Specifically, a nonuniform boron distribution was studied; a skin/dura, a larger blood vessel, and tumor within a head phantom was simulated. The results show that it is possible to determine a homogeneous boron concentration of 5 mug/g within +/-3% (1 standard deviation). In the nonuniform case, this work shows that the boron concentration can be determined through a multistep measurement procedure, however, with a somewhat higher uncertainty (similar to 10%). The present work forms the basis for a subsequent clinical application of the PGS setup aimed at in vivo monitoring of boron uptake.}},
author = {{Munck af Rosenschöld, Per and Verbakel, W. and Ceberg, Crister and Stecher-Rasmussen, F. and Persson, Bertil R}},
issn = {{0094-2405}},
keywords = {{BNCT; Boron measurements; Gamma-ray telescope; In vivo dosimetry; Prompt gamma spectroscopy}},
language = {{eng}},
number = {{5}},
pages = {{787--795}},
publisher = {{American Association of Physicists in Medicine}},
series = {{Medical Physics}},
title = {{Toward clinical application of prompt gamma spectroscopy for in vivo monitoring of boron uptake in boron neutron capture therapy}},
url = {{http://dx.doi.org/10.1118/1.1367281}},
doi = {{10.1118/1.1367281}},
volume = {{28}},
year = {{2001}},
}